Both sides will be looking to take the early advantage in the tie at Olympiastadion.
Hertha finished 16th in the Bundesliga after suffering back-to-back defeats, with Stuttgart leapfrogging them on goal difference after a 2-1 win over FC Koln on the final day.
Now, Felix Magath’s side are desperate to maintain their nine-year top-flight status.
But they will be encouraged by the fact the Bundesliga side has prevailed in eight of the last nine relegation play-offs.
Meanwhile, a timely run of five straight victories saw Tim Walter’s Hamburg snatch third place in 2. Bundesliga – pipping Darmstadt on goal difference.
That came after three successive fourth-place finishes for the Red Shorts, who are aiming to return to the top-flight after four years away.
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Hertha Berlin vs Hamburg match stats
Hamburg’s greatest threat is likely to come from top scorer Robert Glatzel, who has scored 22 goals this season.
And the striker is in form having been directly involved in 10 goals in his last eight appearances – scoring six and assisting four.
The form book would also favour the visitors, who have won their last three matches on the road – netting 11 times along the way.
Although, they have kept just one clean sheet from a possible five.
Hertha Berlin vs Hamburg: Squawka Says
Scoreline prediction: Hertha Berlin 1-2 Hamburg
7:30 pm Thursday May 19
Hertha Berlin 1-2 HamburgBundesliga relegation play-off
March 17, 2018: Hamburg 1-2 Hertha Berlin – Bundesliga
October 28, 2017: Hertha Berlin 2-1 Hamburg – Bundesliga
March 5, 2017: Hamburg 1-0 Hertha Berlin – Bundesliga
October 1, 2016: Hertha Berlin 2-0 Hamburg – Bundesliga
March 6, 2016: Hamburg 2-0 Hertha Berlin – Bundesliga
Hertha have won each of their last five meetings with Hamburg on home soil; scoring at least twice on four of those occasions.