Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO/KY/MD/OH/PA/TN/VA/VT/WV) or (888) 789-7777 or visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), or visit 1800gambler.net (WV)
Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO/KY/MD/OH/PA/TN/VA/VT/WV) or (888) 789-7777 or visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), or visit 1800gambler.net (WV)

Squawka / NFL News / 49ers vs Seahawks Prediction & Tips: Week 5

49ers vs Seahawks Prediction & Tips: Week 5

San Francisco 49ers vs Seattle Seahawks prediction, picks and odds for Week 5 of the 2026 NFL season

San Francisco has not allowed a sack all season. Our 49ers vs Seahawks prediction covers the pick of the week, and Channel 5 has it free.

The San Francisco 49ers are 4-0 with a +58 point differential, the best in football. The Seattle Seahawks are 3-1 and have conceded 579 passing yards, fewer than anyone else. Kickoff is 9.25pm BST.

Squawka Signal · Model read

San Francisco 49ers @ Seattle Seahawks

Week 5 · Sun Oct 11, 4:25 PM ET. Our Signal model makes the Seattle Seahawks favourites by about 2 points, a 56% win probability.

SFSan Francisco 49ersWin prob44%
SEASeattle SeahawksWin prob56%
Projected lineSeattle Seahawks -2

Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 18+. BeGambleAware.org. Please gamble responsibly. Full T&Cs & geo-restrictions apply: BoyleSports, bet365, Sky Bet.

Week 5 · Editorial pick

49ers vs Seahawks: our editor’s props

Two editor’s calls on this game, alongside the live Signal numbers.

49ers AT Seahawks

Our props

TotalUnder 45.5 pointsSeattle concedes a 72.1 opponent passer rating and 28.6% on third down, both among the three best marks in the league. San Francisco has the best offence in football.
★★★☆☆3/5 confidence
Player propJaxon Smith-Njigba 75+ receiving yardsSmith-Njigba has 481 receiving yards from 32 catches, third in the NFL. San Francisco concedes an 87.1 opponent rating, which is respectable rather than suffocating.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 18+ | BeGambleAware.org

49ers vs Seahawks: 2026 form so far

The best record in football against the best pass defence. The table measures each attack against what the opposing team has actually conceded.

49ers attack against the Seahawks defence

Per game49ers offenceSeahawks allow
Passing yards251.8144.8
Rushing yards137.2102.0
Yards per carry4.83.6
Passer rating126.272.1
Touchdowns4.02.0
Third-down conversion57.5%28.6%
Red-zone conversion84.6%66.7%
Sacks conceded / recorded0.02.8

Seahawks attack against the 49ers defence

Per gameSeahawks offence49ers allow
Passing yards237.0209.0
Rushing yards110.299.8
Yards per carry3.93.7
Passer rating112.187.1
Touchdowns3.21.5
Third-down conversion31.1%44.1%
Red-zone conversion56.2%45.5%
Sacks conceded / recorded1.51.5

Figures are season to date, across 4 games.

Zero sacks allowed in four games and 113 pass attempts. No other team is on fewer than five, and Seattle’s eleven sacks make this the matchup the game turns on.

49ers vs Seahawks quarterback matchup

San Francisco’s 126.2 team passer rating is the highest in the league and Seattle’s 112.1 is third. This is the best quarterback matchup on the card.

TeamQuarterbackLast gameSeason to date
49ersBrock Purdy15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg79/113, 1007 yds, 11 TD, 1 INT, 126.2 rtg (4 games)
SeahawksSam Darnold31/45, 379 yds, 4 TD, 2 INT, 105.7 rtg45/69, 560 yds, 6 TD, 3 INT, 101.1 rtg (3 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

49ers vs Seahawks injury report and team news

San Francisco’s receiving room has been thinned by injury, with Ricky Pearsall and Christian Kirk both on injured reserve.

Zach Charbonnet is on injured reserve for Seattle.

Seattle has conceded 579 passing yards, the fewest of any team in the NFL.

Injury report · Week 5Official game-status report — updates through the week
SFSan Francisco 49ers
No game-status designations filed yet.
Out long-term
Nate HobbsCBIR
Alfred CollinsDLIR
Andrew Farmer IIDLIR
Mikail KamaraDLIR
Mykel WilliamsDLIR
Sam OkuayinonuDLIR
C.J. WestDTIR
Nick MartinLBIR
Austen PleasantsOLIR
Brett TothOLIR
Nick ZakeljOLIR
Darrick ForrestSAFIR
Jake TongesTEIR
Christian KirkWRIR
De’Zhaun StriblingWRIR
Demarcus RobinsonWRIR
Ricky PearsallWRIR
Isaac GuerendoRBPUP
SEASeattle Seahawks
No game-status designations filed yet.
Out long-term
Terrion ArnoldCBExempt
Robbie OuztsFBIR
Anthony BradfordGIR
Mason RichmanOLIR
Jadarian PriceRBIR
Zach CharbonnetRBIR
Bud ClarkSAFIR
Irv CharlesWRIR
Jake BoboWRIR

Zero sacks against eleven

San Francisco has given up nothing in 113 attempts, which is why Brock Purdy has eleven touchdown passes and a 126.2 rating. Clean pockets have produced the best offence in football.

Seattle is the first team equipped to break it: eleven sacks, a 72.1 opponent passer rating only Minnesota betters, and 28.6% allowed on third down.

Lumen Field at 9.25pm BST is the best free-to-air watch of the British weekend, and the crowd noise is worth a false start or two on its own.

Players to watch

  • George Kittle (SF, TE): 244 receiving yards in a thinned receiving group.
  • Christian McCaffrey (SF, RB): 218 rushing yards behind a line that has conceded no sacks.
  • Jaxon Smith-Njigba (SEA, WR): 481 receiving yards from 32 catches, third in the NFL.
  • Cooper Kupp (SEA, WR): A second target in a passing game rating 112.1.

How to watch 49ers vs Seahawks

Kickoff is 9.25pm BST on Sunday 11 October at Lumen Field, which is 4:25 PM ET. This one is free-to-air on Channel 5, with coverage from 9:00pm, and it also streams on Channel 5 Sport on YouTube. Free-to-air games are not affected by the Sky blackout. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.

Detail49ers vs Seahawks
DateSunday, October 11, 2026
Kickoff9.25pm BST Sun 11 Oct / 4:25 PM ET
VenueLumen Field, Seattle, WA
TVChannel 5
Live streamNFL Game Pass (DAZN)
WeekWeek 5, 2026 NFL season

49ers vs Seahawks prediction and score projection

Our 49ers vs Seahawks prediction is Seattle 24-21, the upset call of the week. The Seahawks have the pass defence to make San Francisco uncomfortable for the first time.

The model’s number and the live market price for this game both update through the week.

Every Week 5 game, previewed

Kickoff (BST)GameOur predictionPreview
Fri 1:15 AMBuccaneers @ CowboysCowboys 27-20Read
Sun 2:30 PMEagles @ JaguarsJaguars 24-17Read
Sun 6:00 PMBears @ PackersBears 24-20Read
Sun 6:00 PMBengals @ DolphinsBengals 27-16Read
Sun 6:00 PMBrowns @ JetsBrowns 20-17Read
Sun 6:00 PMTexans @ TitansTexans 19-16Read
Sun 6:00 PMColts @ SteelersSteelers 21-20Read
Sun 6:00 PMRaiders @ PatriotsRaiders 23-20Read
Sun 6:00 PMVikings @ SaintsVikings 26-17Read
Sun 6:00 PMGiants @ CommandersGiants 24-17Read
Sun 9:05 PMBroncos @ ChargersBroncos 23-17Read
Sun 9:25 PMLions @ CardinalsLions 27-20Read
Sun 9:25 PM49ers @ SeahawksSeahawks 24-21You are here
Mon 1:20 AMRavens @ FalconsRavens 26-20Read
Tue 1:15 AMBills @ RamsBills 27-23Read

Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.

49ers vs Seahawks FAQ

What time is 49ers vs Seahawks in the UK?

9.25pm BST on Sunday 11 October at Lumen Field, which is 4:25 PM ET.

Is 49ers vs Seahawks free-to-air?

Yes. Channel 5 has it from 9:00pm, and it also streams on Channel 5 Sport on YouTube.

How can I watch 49ers vs Seahawks in the UK?

Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION carry the week’s free-to-air games, and those are not blacked out.

Have San Francisco really not conceded a sack?

No sacks in four games and 113 pass attempts. They are the only team in the NFL yet to allow one.

18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change