Bills vs Rams Prediction & Tips: Week 5

Buffalo has scored 127 points, more than any team in the NFL. Our Bills vs Rams prediction covers Monday night, and it is a 1.15am BST alarm call for anyone in Britain.

The Buffalo Bills are 3-1 and average 5.05 yards a carry. The Los Angeles Rams are 2-2 and have conceded 582 passing yards, fewer than all but one team. They are without Myles Garrett.

Week 5 · Editorial pick

Bills vs Rams: our editor’s props

Two editorial selections to sit with the live Signal read below.

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Our props

Player propJames Cook III 80+ rushing yardsCook has 421 rushing yards, third in the NFL, and Buffalo averages 5.05 a carry. Los Angeles concedes 3.96 a carry, so this is a genuine test.

★★★☆☆3/5 confidence

TotalUnder 47.5 pointsLos Angeles allows a 75.4 opponent passer rating and 33.3% on third down, both among the better marks in the league. Buffalo scores freely.

★★☆☆☆2/5 confidence

An editorial call, not a Signal model output. 18+ | BeGambleAware.org

Bills vs Rams: 2026 form so far

The highest-scoring team in football against one of its stingiest secondaries. The table measures each attack against what the opposite defence has given up.

Bills attack against the Rams defence

Rams attack against the Bills defence

Figures are season to date, across 4 games.

Buffalo’s 127 points lead the league and its 53.3% third-down rate is second only to San Francisco. The Rams have conceded nine touchdowns in four games.

Bills vs Rams quarterback matchup

Buffalo rates 100.1 through the air to the Rams’ 80.4, though Los Angeles has thrown for 1,161 yards, the second-most in the NFL.

Bills vs Rams injury report and team news

Myles Garrett is on injured reserve for Los Angeles, taking out a pass rusher who recorded 23 sacks last season.

Greg Rousseau has six sacks for Buffalo, the most of any player in the NFL.

Davante Adams has 390 receiving yards for the Rams, fifth in the league.

Monday night at SoFi

Buffalo scores in every way available: 127 points, 556 rushing yards at 5.05 a carry, and a 53.3% third-down rate that keeps drives alive.

The Rams have the defence to make it awkward. A 75.4 opponent passer rating is third-best in the NFL and 582 passing yards conceded is second-fewest.

For a UK audience this is the last and hardest watch of the week at 1.15am BST on the Tuesday. This is one for the insomniacs rather than the after-work crowd, and Game Pass has it on demand from the morning if the alarm clock wins.

Players to watch

• James Cook III (BUF, RB): 421 rushing yards, third in the NFL.
• Dalton Kincaid (BUF, TE): 270 receiving yards, joint 13th in the league.
• Davante Adams (LA, WR): 390 receiving yards, fifth in the NFL.
• Kyren Williams (LA, RB): 294 rushing yards against a defence conceding 4.04 a carry.

How to watch Bills vs Rams

Kickoff is 1.15am BST in the early hours of Tuesday 13 October at SoFi Stadium, which is 8:15 PM ET on the Monday. This is not one of Channel 5 or 5ACTION’s free-to-air picks this week, so Sky Sports or NFL Game Pass on DAZN is the route to it. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.

Bills vs Rams prediction and score projection

Our Bills vs Rams prediction is Buffalo 27-23. The Rams have the better secondary and will keep it close, but 127 points in four games is not a sample that corrects itself overnight.

Signal’s live probability and the current market number update through to kickoff.

Every Week 5 game, previewed

Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.

Bills vs Rams FAQ

18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change