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Squawka / NFL News / Lions vs Cardinals Prediction & Tips: Week 5

Lions vs Cardinals Prediction & Tips: Week 5

Detroit Lions vs Arizona Cardinals prediction, picks and odds for Week 5 of the 2026 NFL season

Detroit has conceded 17 touchdowns, more than any team in the NFL, and is somehow 2-2. Our Lions vs Cardinals prediction explains how.

They score. The Detroit Lions have 119 points and a 108.6 passer rating. The Arizona Cardinals are 1-3 and allow a 114.9 opponent rating. Kickoff is 9.25pm BST.

Squawka Signal · Model read

Detroit Lions @ Arizona Cardinals

Week 5 · Sun Oct 11, 4:25 PM ET. Our Signal model makes the Detroit Lions favourites by about 5 points, a 69% win probability.

DETDetroit LionsWin prob69%
ARIArizona CardinalsWin prob31%
Projected lineDetroit Lions -5

Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 18+. BeGambleAware.org. Please gamble responsibly. Full T&Cs & geo-restrictions apply: BoyleSports, bet365, Sky Bet.

Week 5 · Editorial pick

Lions vs Cardinals: our editor’s props

Two editorial selections to sit with the live Signal read below.

Lions AT Cardinals

Our props

TotalOver 48.5 pointsDetroit allows 52.8% on third down and 82.4% in the red zone, both near the bottom of the league. Arizona concedes a 114.9 opponent passer rating.
★★★★☆4/5 confidence
Player propAmon-Ra St. Brown 80+ receiving yardsSt. Brown has 303 receiving yards from 31 catches. Arizona has allowed 935 passing yards and a 114.9 rating, the second-highest figure in the NFL.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 18+ | BeGambleAware.org

Lions vs Cardinals: 2026 form so far

Two defences that have stopped very little, and one offence considerably better than the other. The table puts each attack against what the opposite side allows.

Lions attack against the Cardinals defence

Per gameLions offenceCardinals allow
Passing yards287.2233.8
Rushing yards102.0117.5
Yards per carry4.24.2
Passer rating108.6114.9
Touchdowns3.53.8
Third-down conversion39.1%45.5%
Red-zone conversion72.2%69.2%
Sacks conceded / recorded2.02.0

Cardinals attack against the Lions defence

Per gameCardinals offenceLions allow
Passing yards194.2304.0
Rushing yards100.5119.8
Yards per carry3.94.4
Passer rating83.2110.4
Touchdowns2.24.2
Third-down conversion39.3%52.8%
Red-zone conversion57.1%82.4%
Sacks conceded / recorded1.83.8

Figures are season to date, across 4 games.

Seventeen touchdowns conceded is the most in the league, and a 52.8% third-down rate against is also the worst. Detroit has covered it with points.

Lions vs Cardinals quarterback matchup

Detroit rates 108.6 through the air to Arizona’s 83.2, a 25.4-point gap between two team figures.

TeamQuarterbackLast gameSeason to date
LionsJared Goff25/32, 269 yds, 2 TD, 0 INT, 122.5 rtg109/161, 1214 yds, 9 TD, 0 INT, 108.6 rtg (4 games)
CardinalsJacoby Brissett38/52, 280 yds, 2 TD, 0 INT, 98.2 rtg103/152, 818 yds, 6 TD, 4 INT, 83.2 rtg (4 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

Lions vs Cardinals injury report and team news

James Conner is on injured reserve for Arizona, as is Trey Benson, leaving Jeremiyah Love to carry the backfield.

Aidan Hutchinson has three sacks in a Detroit front that has recorded 15.

Trey McBride has 33 receptions for Arizona, third-most of any player in the league.

Injury report · Week 5Official game-status report — updates through the week
DETDetroit Lions
No game-status designations filed yet.
Out long-term
Cade MaysCIR
Avonte MaddoxDBIR
Brian BranchDBIR
Payton TurnerDEIR
Damone ClarkLBIR
Isiah PachecoRBIR
Thomas HarperSAFIR
Kendrick LawWRIR
Kerby JosephSAFPUP
ARIArizona Cardinals
No game-status designations filed yet.
Out long-term
Will JohnsonCBIR
Kaleb ProctorDLIR
Zach CarterDLIR
Chase BisontisOLIR
Paris Johnson Jr.OLIR
James ConnerRBIR
Trey BensonRBIR
Joey BlountSAFIR
Kitan CrawfordSAFIR
Hunter LongTEIR
Jameson GeersTEIR
Tip ReimanTEPUP

Two defences that cannot get off the field

Detroit’s offence is genuine: a 108.6 team passer rating, 1,149 passing yards, 14 touchdowns and a 72.2% red-zone conversion rate.

Its defence has been the opposite. Seventeen touchdowns and 1,216 passing yards conceded, with 82.4% of opponent red-zone trips finished.

Arizona is not equipped to punish that as much as it should be, rating 83.2 through the air and having conceded 15 touchdowns itself.

Players to watch

  • Jahmyr Gibbs (DET, RB): 353 rushing yards, joint fifth in the NFL.
  • Amon-Ra St. Brown (DET, WR): 303 receiving yards from 31 catches.
  • Trey McBride (ARI, TE): 33 receptions, third-most of any player in the NFL.
  • Michael Wilson (ARI, WR): 258 receiving yards from 25 catches.

How to watch Lions vs Cardinals

Kickoff is 9.25pm BST on Sunday 11 October at State Farm Stadium, which is 4:25 PM ET. This is not one of Channel 5 or 5ACTION’s free-to-air picks this week, so Sky Sports or NFL Game Pass on DAZN is the route to it. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.

DetailLions vs Cardinals
DateSunday, October 11, 2026
Kickoff9.25pm BST Sun 11 Oct / 4:25 PM ET
VenueState Farm Stadium, Glendale, AZ
TVSky Sports
Live streamNFL Game Pass (DAZN)
WeekWeek 5, 2026 NFL season

Lions vs Cardinals prediction and score projection

Our Lions vs Cardinals prediction is Detroit 27-20. The Lions concede more than anyone, but they also score more than Arizona can.

Signal’s live win probability for this game will move once the designations land.

Every Week 5 game, previewed

Kickoff (BST)GameOur predictionPreview
Fri 1:15 AMBuccaneers @ CowboysCowboys 27-20Read
Sun 2:30 PMEagles @ JaguarsJaguars 24-17Read
Sun 6:00 PMBears @ PackersBears 24-20Read
Sun 6:00 PMBengals @ DolphinsBengals 27-16Read
Sun 6:00 PMBrowns @ JetsBrowns 20-17Read
Sun 6:00 PMTexans @ TitansTexans 19-16Read
Sun 6:00 PMColts @ SteelersSteelers 21-20Read
Sun 6:00 PMRaiders @ PatriotsRaiders 23-20Read
Sun 6:00 PMVikings @ SaintsVikings 26-17Read
Sun 6:00 PMGiants @ CommandersGiants 24-17Read
Sun 9:05 PMBroncos @ ChargersBroncos 23-17Read
Sun 9:25 PMLions @ CardinalsLions 27-20You are here
Sun 9:25 PM49ers @ SeahawksSeahawks 24-21Read
Mon 1:20 AMRavens @ FalconsRavens 26-20Read
Tue 1:15 AMBills @ RamsBills 27-23Read

Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.

Lions vs Cardinals FAQ

What time is Lions vs Cardinals in the UK?

9.25pm BST on Sunday 11 October at State Farm Stadium, which is 4:25 PM ET.

How can I watch Lions vs Cardinals in the UK?

Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION carry the week’s free-to-air games, and those are not blacked out.

Is Lions vs Cardinals free-to-air?

No. This is not one of Channel 5 or 5ACTION’s free-to-air picks this week.

How bad is Detroit’s defence?

It has conceded 17 touchdowns and allows 52.8% on third down, both the worst marks in the NFL.

18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change