49ers vs Cowboys Prediction & Tips: Week 10

San Francisco score 3.9 touchdowns a game and convert 84.6% in the red zone, both the best figures in the NFL. Dallas concede 48.3% on third down, the worst. Our 49ers vs Cowboys prediction is the league’s best offence against its most generous defence.

The San Francisco 49ers are 7-1 at +79. The Dallas Cowboys are 4-5 and have conceded 236 points in nine games.

Week 10 · Editorial pick

49ers vs Cowboys: our editor’s props

Two editorial selections to sit with the live Signal read below.

AT

Our props

Player propSan Francisco 3+ touchdownsSan Francisco score 3.9 a game and convert 84.6% in the red zone, both the best in the NFL.

★★★★☆4/5 confidence

Player propDak Prescott 250+ passing yardsDallas throw for 257 a game and Prescott had 335 last week. San Francisco concede 211.

★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 18+ | BeGambleAware.org

49ers vs Cowboys: 2026 form so far

The best offence in football against a defence that cannot get off the field. The columns put each side’s output next to what the other has conceded so far.

49ers attack against the Cowboys defence

Cowboys attack against the 49ers defence

Dallas concede 48.3% on third down, the highest rate in the NFL, and 147 rushing yards a game, which is 31st.

49ers vs Cowboys quarterback matchup

Brock Purdy threw for 232 yards and two touchdowns at 107.4 in a 38-17 win. Dak Prescott went 21 of 34 for 335 and two scores at 114.2.

49ers vs Cowboys injury report and team news

San Francisco score 3.9 touchdowns a game and convert 84.6% in the red zone, both the best in the NFL.

Dallas concede 48.3% on third down, the worst rate in the league.

San Francisco concede 3.33 yards a carry and 81 rushing yards a game, the best figures in the NFL.

The best offence in football against the most generous third down

San Francisco are 7-1 and the offence is unusually efficient: 3.9 touchdowns a game, 84.6% in the red zone and 51.7% on third down are first, first and second.

The defence is no weaker. Opponents run at 3.33 a carry for 81 yards a game, both the best marks in the league, and score 1.9 touchdowns.

Dallas can score — 3.1 touchdowns a game and 71.4% in the red zone, third — and Prescott threw for 335 last week. Stopping anyone is the trouble: 48.3% on third down and 147 rushing yards conceded.

Players to watch

• Brock Purdy (SF, QB): Rates 109.8 in an offence converting 84.6% in the red zone.
• George Kittle (SF, TE): A primary target in the league’s most efficient offence.
• Dak Prescott (DAL, QB): 335 yards and two touchdowns at 114.2 last week.
• CeeDee Lamb (DAL, WR): Led Dallas receivers in the win over Indianapolis.

How to watch 49ers vs Cowboys

Kickoff is 9.25pm GMT on Sunday 15 November at AT&T Stadium, which is 4:25 PM ET. Channel 5 and 5ACTION show selected games free-to-air each Sunday, and those are not affected by the blackout. Check their listings for this week’s picks. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the two Sunday afternoon windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.

49ers vs Cowboys prediction and score projection

Our 49ers vs Cowboys prediction is San Francisco by 34-24. Dallas will score, because they always do, and 48.3% conceded on third down against this offence is not survivable.

The projected margin on this page updates through the week.

Every Week 10 game, previewed

Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.

49ers vs Cowboys FAQ

18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change