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Lions vs Cardinals Prediction, Picks & Odds

Detroit Lions vs Arizona Cardinals prediction, picks and odds for Week 5 of the 2026 NFL season

Detroit has conceded 17 touchdowns, more than any team in the NFL, and allows opponents 52.8% on third down, also the worst mark in the league. Our Lions vs Cardinals prediction explains how it is still 2-2.

It scores. The Detroit Lions have 119 points and a 108.6 passer rating, and have been outscoring the damage. The Arizona Cardinals are 1-3, have conceded 15 touchdowns of their own, and allow a 114.9 opponent rating.

Week 5 · Editorial pick

Lions vs Cardinals: our editor’s props

Two editorial selections to sit with the live Signal read below.

Lions AT Cardinals

Our props

TotalOver 48.5 pointsDetroit lets opponents convert 52.8% on third down and finish 82.4% of red-zone trips. Arizona concedes a 114.9 opponent rating. Thirty-two touchdowns between them in eight games.
★★★★☆4/5 confidence
Player propAmon-Ra St. Brown 80+ receiving yardsSt. Brown has 303 yards on 31 catches. Arizona has given up 935 through the air at 114.9, second-worst in the league.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.

Lions vs Cardinals: 2026 form so far

Two defences that have stopped very little, and one offence considerably better than the other. The table puts each attack against what the opposite team allows.

Lions attack against the Cardinals defence

Per gameLions offenceCardinals allow
Passing yards287.2233.8
Rushing yards102.0117.5
Yards per carry4.24.2
Passer rating108.6114.9
Touchdowns3.53.8
Third-down conversion39.1%45.5%
Red-zone conversion72.2%69.2%
Sacks conceded / recorded2.02.0

Cardinals attack against the Lions defence

Per gameCardinals offenceLions allow
Passing yards194.2304.0
Rushing yards100.5119.8
Yards per carry3.94.4
Passer rating83.2110.4
Touchdowns2.24.2
Third-down conversion39.3%52.8%
Red-zone conversion57.1%82.4%
Sacks conceded / recorded1.83.8

Figures are season to date, across 4 games.

Seventeen touchdowns conceded is the most in the league, and a 52.8% third-down conversion rate against is also the worst. Detroit has covered it with points.

Lions vs Cardinals quarterback matchup

Detroit rates 108.6 through the air to Arizona’s 83.2, a 25.4-point gap. Both are team figures rather than the starters’ own numbers.

TeamQuarterbackLast gameSeason to date
LionsJared Goff25/32, 269 yds, 2 TD, 0 INT, 122.5 rtg109/161, 1214 yds, 9 TD, 0 INT, 108.6 rtg (4 games)
CardinalsJacoby Brissett38/52, 280 yds, 2 TD, 0 INT, 98.2 rtg103/152, 818 yds, 6 TD, 4 INT, 83.2 rtg (4 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

Lions vs Cardinals injury report and team news

James Conner is on injured reserve for Arizona, as is Trey Benson, leaving Jeremiyah Love to carry the backfield.

Aidan Hutchinson has three sacks in a Detroit front that has recorded 15, second-most in the NFL.

Trey McBride has 33 receptions for Arizona, third-most of any player in the league.

Two defences that cannot get off the field

Detroit’s offence is genuine. A 108.6 team passer rating, 1,149 passing yards, 14 touchdowns and a 72.2% red-zone conversion rate make it one of the better attacks in football, and Jahmyr Gibbs has 353 rushing yards on top.

Its defence has been the opposite. Seventeen touchdowns and 1,216 passing yards conceded, a 52.8% third-down rate against, 82.4% of opponent red-zone trips finished.

Arizona is not equipped to punish that as much as it should be. It rates 83.2 through the air and has conceded 15 touchdowns itself, so this becomes a question of which poor defence faces the better offence.

Players to watch

  • Jahmyr Gibbs (DET, RB): 353 yards, tied for fifth in the league.
  • Amon-Ra St. Brown (DET, WR): 303 yards from 31 catches.
  • Trey McBride (ARI, TE): 33 receptions, third-most of anyone in football.
  • Michael Wilson (ARI, WR): 258 yards from 25 catches.

How to watch Lions vs Cardinals

Kickoff is 4:25 PM ET on Sunday, October 11 at State Farm Stadium in Glendale. CTV carries one Sunday afternoon game per region and the selection is local, so confirm it in your own listings. The French-language broadcast is on RDS. DAZN carries every game of the season in Canada through NFL Game Pass. Squawka may earn a commission if you subscribe through that link.

DetailLions vs Cardinals
DateSunday, October 11, 2026
Kickoff4:25 PM ET / 3:25 PM CT / 1:25 PM PT
VenueState Farm Stadium, Glendale, AZ
TVCTV (regional) / TSN / RDS (French)
Live streamDAZN (NFL Game Pass)
WeekWeek 5, 2026 NFL season

Lions vs Cardinals prediction and score projection

Our Lions vs Cardinals prediction is Detroit 27-20. The Lions concede more than anyone, but they also score more than Arizona can.

Signal’s live win probability will move once the designations land.

Every Week 5 game, previewed

Kickoff (ET)GameOur predictionPreview
Thu 8:15 PMBuccaneers @ CowboysCowboys 27-20Read
Sun 9:30 AMEagles @ JaguarsJaguars 24-17Read
Sun 1:00 PMBears @ PackersBears 24-20Read
Sun 1:00 PMBengals @ DolphinsBengals 27-16Read
Sun 1:00 PMBrowns @ JetsBrowns 20-17Read
Sun 1:00 PMTexans @ TitansTexans 19-16Read
Sun 1:00 PMColts @ SteelersSteelers 21-20Read
Sun 1:00 PMRaiders @ PatriotsRaiders 23-20Read
Sun 1:00 PMVikings @ SaintsVikings 26-17Read
Sun 1:00 PMGiants @ CommandersGiants 24-17Read
Sun 4:05 PMBroncos @ ChargersBroncos 23-17Read
Sun 4:25 PMLions @ CardinalsLions 27-20You are here
Sun 4:25 PM49ers @ SeahawksSeahawks 24-21Read
Sun 8:20 PMRavens @ FalconsRavens 26-20Read
Mon 8:15 PMBills @ RamsBills 27-23Read

You can find the other games on our NFL hub, with Signal’s read on all of Week 5 alongside them. Both these teams are chasing the NFC Championship odds, with the AFC Championship odds tracked alongside them through the season.

Lions vs Cardinals FAQ

Who is favoured, the Lions or the Cardinals?

Detroit. The Lions are 2-2 with 119 points scored; Arizona is 1-3 and has been outscored by 30.

What time is Lions vs Cardinals in Canada?

4:25 PM ET on Sunday, October 11, which is 3:25 PM CT and 1:25 PM PT, at State Farm Stadium.

How bad is Detroit’s defence?

It has conceded 17 touchdowns and allows 52.8% on third down, both the worst marks in the NFL.

Is James Conner playing for Arizona?

No. Conner is on injured reserve, as is Trey Benson.

19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change