Our Broncos vs 49ers prediction is the most one-sided call on the card, and it involves the only offense yet to concede a sack. Squawka Signal’s live read on this game, including where the value sits, updates on this page through the week.
The San Francisco 49ers are 3-0 with a 133.1 passer rating and 13 touchdowns. The Denver Broncos have allowed 431 rushing yards at 5.1 a carry. Levi’s Stadium hosts the most accomplished team in the league against one that cannot stop the run.
Broncos vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.
Broncos vs 49ers: 2026 form so far
The most efficient offense in the league against a defense that cannot stop the run. The table puts each attack against what the opposite side has actually allowed.
Broncos attack against the 49ers defense
| Per game | Broncos offense | 49ers allow |
|---|---|---|
| Passing yards | 194.0 | 207.3 |
| Rushing yards | 81.0 | 105.7 |
| Yards per carry | 3.6 | 3.7 |
| Passer rating | 80.3 | 89.7 |
| Touchdowns | 2.3 | 1.7 |
| Third-down conversion | 36.1% | 42.9% |
| Red-zone conversion | 60.0% | 40.0% |
| Sacks conceded / recorded | 1.7 | 2.0 |
49ers attack against the Broncos defense
| Per game | 49ers offense | Broncos allow |
|---|---|---|
| Passing yards | 263.0 | 237.0 |
| Rushing yards | 136.3 | 143.7 |
| Yards per carry | 5.1 | 5.1 |
| Passer rating | 133.1 | 74.3 |
| Touchdowns | 4.3 | 2.3 |
| Third-down conversion | 63.0% | 47.8% |
| Red-zone conversion | 90.0% | 45.5% |
| Sacks conceded / recorded | 0.0 | 2.7 |
Read these as a 3-game sample rather than settled form. Rates this early move a long way on one result.
San Francisco convert 63% on third down and 90% in the red zone. No other team is above 58% or 89% respectively, which is why this is the only 5/5 call this week.
Broncos vs 49ers quarterback matchup
Brock Purdy has nine touchdown passes to one interception. Bo Nix has four to three.
| Team | Quarterback | Last game | Season to date |
|---|---|---|---|
| Broncos | Bo Nix | 17/34, 186 yds, 2 TD, 1 INT, 73.9 rtg | 56/93, 605 yds, 4 TD, 3 INT, 80.3 rtg (3 games) |
| 49ers | Brock Purdy | 15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg | 60/83, 789 yds, 9 TD, 1 INT, 133.1 rtg (3 games) |
Broncos vs 49ers injury report and team news
San Francisco have not conceded a sack in three games, the only offensive line in the league with a clean sheet.
Jonathon Cooper is on the exempt list for Denver, so the Broncos are without the pass rusher who recorded eight sacks last season.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Where Broncos vs 49ers is decided
San Francisco have conceded no sacks in three games. Brock Purdy has been hit, but not brought down once, and from that pocket he has thrown nine touchdown passes to one interception at a 133.1 rating.
The efficiency numbers follow from it. Sixty-three per cent on third down and 90% in the red zone are both the best marks in the league, and the 49ers have scored 13 touchdowns while conceding five.
Denver are not a bad team. They are 2-1, they beat the Rams 30-26, and their defense has eight sacks and four interceptions. But they have allowed 431 rushing yards at 5.1 a carry, and San Francisco run at 5.1 themselves.
Players to watch
- Bo Nix (DEN, QB): 186 yards and two touchdowns against the Rams, plus a rushing score.
- Courtland Sutton (DEN, WR): Three catches for 46 yards in Week 3.
- Brock Purdy (SF, QB): 297 yards and four touchdowns against Arizona at a 133.8 rating.
- George Kittle (SF, TE): Six catches for 82 yards and two touchdowns in Week 3.
How to watch Broncos vs 49ers
Kickoff is 4:25 PM ET on Sunday, October 4 at Levi’s Stadium, which is 3:25 PM CT and 1:25 PM PT. CBS has the regional broadcast.
| Detail | Broncos vs 49ers |
|---|---|
| Date | Sunday, October 4, 2026 |
| Kickoff | 4:25 PM ET / 3:25 PM CT / 1:25 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | CBS |
| Live stream | NFL+ / Paramount+ |
| Week | Week 4, 2026 NFL season |
Broncos vs 49ers prediction and score projection
Our Broncos vs 49ers prediction is a San Francisco win, 31-17. The 49ers lead the league in third-down and red-zone conversion, have conceded no sacks, and are at home. This is the most confident call on the card.
The live win probability and the model’s projected margin update on this page through the week.
Every Week 4 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Steelers @ Browns | Browns 20-17 | Read |
| Sun 9:30 AM | Colts @ Commanders | Commanders 27-24 | Read |
| Sun 1:00 PM | Cardinals @ Giants | Cardinals 24-20 | Read |
| Sun 1:00 PM | Cowboys @ Texans | Cowboys 27-24 | Read |
| Sun 1:00 PM | Packers @ Buccaneers | Packers 23-20 | Read |
| Sun 1:00 PM | Jaguars @ Bengals | Jaguars 24-20 | Read |
| Sun 1:00 PM | Rams @ Eagles | Rams 24-20 | Read |
| Sun 1:00 PM | Patriots @ Bills | Bills 30-16 | Read |
| Sun 1:00 PM | Jets @ Bears | Bears 27-24 | Read |
| Sun 1:00 PM | Titans @ Ravens | Ravens 27-13 | Read |
| Sun 4:05 PM | Dolphins @ Vikings | Vikings 24-13 | Read |
| Sun 4:25 PM | Broncos @ 49ers | 49ers 31-17 | You are here |
| Sun 4:25 PM | Chiefs @ Raiders | Chiefs 27-24 | Read |
| Sun 4:25 PM | Chargers @ Seahawks | Seahawks 27-17 | Read |
| Sun 8:20 PM | Lions @ Panthers | Lions 31-24 | Read |
| Mon 8:15 PM | Falcons @ Saints | Saints 26-23 | Read |
Every fixture in the round is covered across our NFL hub, and Signal rates every game on the NFL picks page.
Broncos vs 49ers FAQ
San Francisco, comfortably, at home. The 49ers are 3-0 with the best point differential in the league; Denver are 2-1.
4:25 PM ET on Sunday, October 4, at Levi’s Stadium.
Not one in three games. They are the only team in the league yet to concede a sack this season.
Denver beat the Los Angeles Rams 30-26. San Francisco beat Arizona 36-30.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change