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Bills vs Raiders Prediction, Picks & Odds

Buffalo Bills vs Las Vegas Raiders prediction, picks and odds for Week 6 of the 2026 NFL season

Buffalo concede on 76.2% of opponent red-zone trips. Las Vegas concede on 77.8%. Our Bills vs Raiders prediction pairs two of the three worst red-zone defenses in football.

The Buffalo Bills lead the NFL with 164 points, level with Detroit, and have scored 20 touchdowns. The Las Vegas Raiders are 3-2 and have conceded 17 touchdowns, so this should not be quiet.

Squawka Signal · Model vs market

Buffalo Bills @ Las Vegas Raiders

Week 6 · Sun Oct 18, 4:25 PM ET. Our Signal model makes the Buffalo Bills favorites by about 8 points, a 78% win probability.

BUFBuffalo BillsSquawka78%Market69%▲ Value
LVLas Vegas RaidersSquawka22%Market31%▼ Slight lay
Projected lineBuffalo Bills -8
Against the spreadBuffalo Bills -5 — model Buffalo Bills -8 vs market Buffalo Bills -5
ValueBuffalo Bills — model 78% vs market 69%

Squawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.

Week 6 · Editorial pick

Bills vs Raiders: our editor’s props

Two editorial selections to sit with the live Signal read below.

Bills AT Raiders

Our props

TotalOver 48.5 pointsBuffalo and Las Vegas concede 76.2% and 77.8% of red-zone trips respectively, two of the three worst rates in the league. Buffalo lead the NFL in points scored.
★★★★☆4/5 confidence
Player propJames Cook III 80+ rushing yardsCook has 532 rushing yards, third in the NFL, and Buffalo average 5.37 a carry. Las Vegas concede 5.21, the second-worst figure in the league.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.

Bills vs Raiders: 2026 form so far

Two defenses that cannot finish a stop, and one offense scoring more than anyone. The table sets each attack against what the other has conceded.

Bills attack against the Raiders defense

Per gameBills offenseRaiders allow
Passing yards238.2236.4
Rushing yards158.0140.6
Yards per carry5.45.2
Passer rating99.699.6
Touchdowns4.03.4
Third-down conversion50.0%42.2%
Red-zone conversion71.4%77.8%
Sacks conceded / recorded2.02.6

Raiders attack against the Bills defense

Per gameRaiders offenseBills allow
Passing yards253.6280.4
Rushing yards82.0108.2
Yards per carry3.03.9
Passer rating100.2105.7
Touchdowns2.83.6
Third-down conversion39.4%42.6%
Red-zone conversion55.6%76.2%
Sacks conceded / recorded1.62.2

Figures are season to date, across 5 games.

Las Vegas concede 5.21 yards a carry, second-worst in the NFL, and Buffalo run for 5.37. That is the mismatch this game turns on.

Bills vs Raiders quarterback matchup

Las Vegas rate 100.2 through the air and Buffalo 99.6, which is the closest quarterback matchup on this week’s card.

TeamQuarterbackLast gameSeason to date
BillsJosh Allen16/26, 204 yds, 0 TD, 2 INT, 54.0 rtg79/119, 1039 yds, 6 TD, 3 INT, 100.1 rtg (4 games)
RaidersKirk Cousins22/33, 248 yds, 3 TD, 0 INT, 119.3 rtg93/144, 1026 yds, 11 TD, 4 INT, 99.5 rtg (4 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

Bills vs Raiders injury report and team news

Buffalo have scored 164 points, level with Detroit for the most in the NFL.

James Cook III has 532 rushing yards, third in the league, and Buffalo have 13 rushing touchdowns.

Greg Rousseau has six sacks for Buffalo, second in the NFL behind Will Anderson Jr.

Injury report · Week 6Official game-status report — updates through the week
BUFBuffalo Bills
No game-status designations filed yet.
Out long-term
Dorian StrongCBIR
Jordan HancockDBIR
Zane DurantDLIR
Tyrell ShaversWRPUP
LVLas Vegas Raiders
No game-status designations filed yet.
Out long-term
Chigozie AnusiemCBIR
Keyron CrawfordDEIR
Justin PickettGIR
Brennan JacksonLBIR
Chris CollierRBIR
Carter RunyonTEIR
Corey RuckerWRIR
Dont’e Thornton Jr.WRIR
Jack BechWRIR

Neither of these defenses finishes a stop

Buffalo have scored 164 points and 20 touchdowns, 13 of them on the ground. James Cook III’s 532 rushing yards are third in the league and the team runs for 5.37 a carry.

Las Vegas concede 5.21 a carry, which is the second-worst figure in football, and 703 rushing yards have gone through that front in five games.

The Raiders can score too. Kirk Cousins has 12 touchdown passes, Brock Bowers has 312 receiving yards, and Buffalo concede on 76.2% of red-zone trips. Both totals should move.

Players to watch

  • James Cook III (BUF, RB): 532 rushing yards, third in the NFL, at 5.37 a carry as a team.
  • Greg Rousseau (BUF, OLB): Six sacks, second in the league.
  • Brock Bowers (LV, TE): 312 receiving yards for an offense rating 100.2.
  • Ashton Jeanty (LV, RB): 291 rushing yards against a defense conceding 3.92 a carry.

How to watch Bills vs Raiders

Kickoff is 4:25 PM ET on Sunday, October 18 at Allegiant Stadium, which is 3:25 PM CT and 1:25 PM PT. CBS has the regional broadcast.

DetailBills vs Raiders
DateSunday, October 18, 2026
Kickoff4:25 PM ET / 3:25 PM CT / 1:25 PM PT
VenueAllegiant Stadium, Paradise, NV
TVCBS
Live streamNFL+ / Paramount+
WeekWeek 6, 2026 NFL season

Bills vs Raiders prediction and score projection

Buffalo win 30-27. Both red-zone defenses leak and both offenses are capable, but the Bills have scored 32 more points than the Raiders.

The live spread and Signal’s projected margin update through the week.

Every Week 6 game, previewed

Kickoff (ET)GameOur predictionPreview
Thu 8:15 PMSeahawks @ BroncosSeahawks 24-20Read
Sun 9:30 AMTexans @ JaguarsJaguars 27-17Read
Sun 1:00 PMRavens @ BrownsRavens 27-16Read
Sun 1:00 PMPanthers @ EaglesPanthers 24-20Read
Sun 1:00 PMBears @ FalconsBears 23-20Read
Sun 1:00 PMSaints @ GiantsGiants 26-20Read
Sun 1:00 PMJets @ PatriotsPatriots 24-17Read
Sun 1:00 PMSteelers @ BuccaneersSteelers 23-17Read
Sun 1:00 PMTitans @ ColtsColts 23-13Read
Sun 4:05 PMCardinals @ RamsRams 30-20Read
Sun 4:25 PMBills @ RaidersBills 30-27You are here
Sun 4:25 PMChargers @ ChiefsChiefs 31-13Read
Sun 8:20 PMCowboys @ PackersPackers 27-24Read
Mon 8:15 PMCommanders @ 49ers49ers 31-17Read

The rest of the round sits in NFL predictions for the round and our NFL hub. The outright markets are priced in our Super Bowl board. For the player side of this game, see player prop betting.

Bills vs Raiders FAQ

Who is favored, the Bills or the Raiders?

Buffalo. The Bills are 4-1 at +23; Las Vegas are 3-2 at +3.

What time is Bills vs Raiders?

4:25 PM ET on Sunday, October 18, at Allegiant Stadium.

Which team has scored the most points this season?

Buffalo, with 164, level with Detroit across the league.

Why should this be high-scoring?

Buffalo concede 76.2% of red-zone trips and Las Vegas 77.8%, two of the three worst rates in the NFL.

21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change