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Squawka / NFL News / Broncos vs 49ers Prediction & Tips: Week 4

Broncos vs 49ers Prediction & Tips: Week 4

Denver Broncos vs San Francisco 49ers prediction, picks and odds for Week 4 of the 2026 NFL season

Our Broncos vs 49ers prediction closes Channel 5’s free-to-air Sunday, and it is the most one-sided call of the round. Squawka Signal’s live read updates on this page through the week.

The San Francisco 49ers are 3-0 with a 133.1 passer rating and 13 touchdowns. The Denver Broncos have allowed 431 rushing yards at 5.1 a carry. Levi’s Stadium hosts the league’s most accomplished team against one that cannot stop the run.

Week 4 · Editorial pick

Broncos vs 49ers: our editor’s props

Two editorial calls to sit alongside the live Signal numbers on this page.

Broncos AT 49ers

Our props

SpreadSan Francisco to win by 10 or moreSan Francisco convert 63% on third down and 90% in the red zone, both league highs, and have conceded no sacks.
★★★★★5/5 confidence
Player propBrock Purdy 2+ passing touchdownsPurdy has nine touchdown passes to one interception at a 133.1 rating.
★★★★☆4/5 confidence

An editorial call, not a Signal model output. 18+ | BeGambleAware.org

Broncos vs 49ers: 2026 form so far

The most efficient offence in the league against a defence leaking on the ground. The table weighs each attack against the yardage the other side has been giving up.

Broncos attack against the 49ers defence

Per gameBroncos offence49ers allow
Passing yards194.0207.3
Rushing yards81.0105.7
Yards per carry3.63.7
Passer rating80.389.7
Touchdowns2.31.7
Third-down conversion36.1%42.9%
Red-zone conversion60.0%40.0%
Sacks conceded / recorded1.72.0

49ers attack against the Broncos defence

Per game49ers offenceBroncos allow
Passing yards263.0237.0
Rushing yards136.3143.7
Yards per carry5.15.1
Passer rating133.174.3
Touchdowns4.32.3
Third-down conversion63.0%47.8%
Red-zone conversion90.0%45.5%
Sacks conceded / recorded0.02.7

Read these as a 3-game sample rather than settled form. Rates this early move a long way on one result.

San Francisco convert 63% on third down and 90% in the red zone. No other team is above 58% or 89%, which is why this is the only 5/5 call this week.

Broncos vs 49ers quarterback matchup

Brock Purdy has nine touchdown passes to one interception. Bo Nix has four to three.

TeamQuarterbackLast gameSeason to date
BroncosBo Nix17/34, 186 yds, 2 TD, 1 INT, 73.9 rtg56/93, 605 yds, 4 TD, 3 INT, 80.3 rtg (3 games)
49ersBrock Purdy15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg60/83, 789 yds, 9 TD, 1 INT, 133.1 rtg (3 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

Broncos vs 49ers injury report and team news

San Francisco have not conceded a sack in three games, the only offensive line in the league with a clean sheet.

Jonathon Cooper is on the exempt list for Denver, a year after recording eight sacks.

This section updates as soon as the Out, Doubtful and Questionable tags land.

Where Broncos vs 49ers is decided

No sacks conceded in three games. Purdy has been hit but never brought down, and from that pocket has thrown nine touchdowns to one interception.

The efficiency follows: 63% on third down and 90% in the red zone are both league highs, and the 49ers have scored 13 touchdowns while conceding five.

Denver are not poor. They are 2-1 and beat the Rams 30-26 with eight sacks and four interceptions of their own. But 431 rushing yards allowed at 5.1 a carry is the flaw San Francisco are built to punish.

Players to watch

  • Bo Nix (DEN, QB): 186 yards and two touchdowns against the Rams.
  • Courtland Sutton (DEN, WR): Three catches for 46 yards in Week 3.
  • Brock Purdy (SF, QB): 297 yards and four touchdowns against Arizona.
  • George Kittle (SF, TE): Six catches for 82 yards and two touchdowns in Week 3.

How to watch Broncos vs 49ers

Kickoff is 9.25pm BST on Sunday 4 October at Levi’s Stadium, which is 4:25 PM ET. Channel 5 has it free to air from 9pm, and it also streams on Channel 5 Sport’s YouTube channel. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.

DetailBroncos vs 49ers
DateSunday, October 4, 2026
Kickoff9.25pm BST / 4:25 PM ET, Sunday 4 October
VenueLevi’s Stadium, Santa Clara, CA
TVChannel 5
Live streamNFL Game Pass (DAZN)
WeekWeek 4, 2026 NFL season

Broncos vs 49ers prediction and score projection

Our Broncos vs 49ers prediction is a San Francisco win, 31-17. The 49ers lead the league in third-down and red-zone conversion and have conceded no sacks.

The live win probability and the model’s projected margin update on this page through the week.

Every Week 4 game, previewed

Kickoff (BST)GameOur predictionPreview
Fri 1:15 AMSteelers @ BrownsBrowns 20-17Read
Sun 2:30 PMColts @ CommandersCommanders 27-24Read
Sun 6:00 PMCardinals @ GiantsCardinals 24-20Read
Sun 6:00 PMCowboys @ TexansCowboys 27-24Read
Sun 6:00 PMPackers @ BuccaneersPackers 23-20Read
Sun 6:00 PMJaguars @ BengalsJaguars 24-20Read
Sun 6:00 PMRams @ EaglesRams 24-20Read
Sun 6:00 PMPatriots @ BillsBills 30-16Read
Sun 6:00 PMJets @ BearsBears 27-24Read
Sun 6:00 PMTitans @ RavensRavens 27-13Read
Sun 9:05 PMDolphins @ VikingsVikings 24-13Read
Sun 9:25 PMBroncos @ 49ers49ers 31-17You are here
Sun 9:25 PMChiefs @ RaidersChiefs 27-24Read
Sun 9:25 PMChargers @ SeahawksSeahawks 27-17Read
Mon 1:20 AMLions @ PanthersLions 31-24Read
Tue 1:15 AMFalcons @ SaintsSaints 26-23Read

Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.

Broncos vs 49ers FAQ

Is Broncos vs 49ers on free-to-air TV in the UK?

Yes. Channel 5 has it from 9pm ahead of a 9.25pm BST kickoff, and it also streams free on Channel 5 Sport’s YouTube channel. Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION carry the week’s free-to-air games, and those are not blacked out.

What time is Broncos vs 49ers in the UK?

9.25pm BST on Sunday 4 October at Levi’s Stadium, which is 4:25 PM ET.

Is this game blacked out on Game Pass?

No. Channel 5 games are not affected by the blackout, which applies only to Sky’s two Sunday exclusive picks.

Have the 49ers really not conceded a sack?

Not one in three games. They are the only team in the league yet to concede a sack this season.

18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change