Our Broncos vs 49ers prediction covers the most complete team in the league. Squawka Signal’s live read updates on this page through the week.
The San Francisco 49ers are 3-0 with the best point differential in football at plus 48. The Denver Broncos have allowed 431 rushing yards at 5.1 a carry. Levi’s Stadium hosts the widest gap in quality on the card.
Broncos vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.
Broncos vs 49ers: 2026 form so far
An unbeaten team with league-leading efficiency against a defence leaking on the ground. The table puts each attack against what the opposite side allows.
Broncos attack against the 49ers defence
| Per game | Broncos offence | 49ers allow |
|---|---|---|
| Passing yards | 194.0 | 207.3 |
| Rushing yards | 81.0 | 105.7 |
| Yards per carry | 3.6 | 3.7 |
| Passer rating | 80.3 | 89.7 |
| Touchdowns | 2.3 | 1.7 |
| Third-down conversion | 36.1% | 42.9% |
| Red-zone conversion | 60.0% | 40.0% |
| Sacks conceded / recorded | 1.7 | 2.0 |
49ers attack against the Broncos defence
| Per game | 49ers offence | Broncos allow |
|---|---|---|
| Passing yards | 263.0 | 237.0 |
| Rushing yards | 136.3 | 143.7 |
| Yards per carry | 5.1 | 5.1 |
| Passer rating | 133.1 | 74.3 |
| Touchdowns | 4.3 | 2.3 |
| Third-down conversion | 63.0% | 47.8% |
| Red-zone conversion | 90.0% | 45.5% |
| Sacks conceded / recorded | 0.0 | 2.7 |
Read these as a 3-game sample rather than settled form. Rates this early move a long way on one result.
San Francisco have conceded no sacks and convert 90% of red-zone trips. Denver concede 5.1 a carry.
Broncos vs 49ers quarterback matchup
Brock Purdy sits at a 133.1 rating for the season. Bo Nix is at 80.3 from 10 more attempts.
| Team | Quarterback | Last game | Season to date |
|---|---|---|---|
| Broncos | Bo Nix | 17/34, 186 yds, 2 TD, 1 INT, 73.9 rtg | 56/93, 605 yds, 4 TD, 3 INT, 80.3 rtg (3 games) |
| 49ers | Brock Purdy | 15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg | 60/83, 789 yds, 9 TD, 1 INT, 133.1 rtg (3 games) |
Broncos vs 49ers injury report and team news
Jonathon Cooper is on the exempt list for Denver after recording eight sacks last season.
George Kittle caught six passes for 82 yards and two touchdowns against Arizona.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Where Broncos vs 49ers is decided
San Francisco are the only team yet to concede a sack. That protection is why Purdy has nine touchdown passes and one interception.
Denver’s defence has eight sacks and four interceptions, and they beat the Rams 30-26. The run defence is the exception, at 431 yards allowed.
San Francisco run at 5.1 a carry themselves, which is precisely the weakness on offer.
Players to watch
- Bo Nix (DEN, QB): 186 yards and two touchdowns against the Rams.
- Courtland Sutton (DEN, WR): Three catches for 46 yards in Week 3.
- Brock Purdy (SF, QB): 297 yards and four touchdowns against Arizona.
- George Kittle (SF, TE): Six catches for 82 yards and two touchdowns in Week 3.
How to watch Broncos vs 49ers
Kickoff is 4:25 PM ET on Sunday 4 October at Levi’s Stadium, which is 3:25 PM CT and 1:25 PM PT. CTV coverage is regional, so the fixture on your local CTV station depends where you are, with TSN alongside it and RDS in French. DAZN carries every game of the season in Canada. Squawka may earn a commission if you subscribe through that link.
| Detail | Broncos vs 49ers |
|---|---|
| Date | Sunday, October 4, 2026 |
| Kickoff | 4:25 PM ET / 3:25 PM CT / 1:25 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | CTV (regional) / TSN / RDS (French) |
| Live stream | DAZN |
| Week | Week 4, 2026 NFL season |
Broncos vs 49ers prediction and score projection
Our Broncos vs 49ers prediction is a San Francisco win, 31-17, rated 5/5. It is the only maximum-confidence call of the round.
The live win probability and the model’s projected margin update on this page through the week.
Every Week 4 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Steelers @ Browns | Browns 20-17 | Read |
| Sun 9:30 AM | Colts @ Commanders | Commanders 27-24 | Read |
| Sun 1:00 PM | Cardinals @ Giants | Cardinals 24-20 | Read |
| Sun 1:00 PM | Cowboys @ Texans | Cowboys 27-24 | Read |
| Sun 1:00 PM | Packers @ Buccaneers | Packers 23-20 | Read |
| Sun 1:00 PM | Jaguars @ Bengals | Jaguars 24-20 | Read |
| Sun 1:00 PM | Rams @ Eagles | Rams 24-20 | Read |
| Sun 1:00 PM | Patriots @ Bills | Bills 30-16 | Read |
| Sun 1:00 PM | Jets @ Bears | Bears 27-24 | Read |
| Sun 1:00 PM | Titans @ Ravens | Ravens 27-13 | Read |
| Sun 4:05 PM | Dolphins @ Vikings | Vikings 24-13 | Read |
| Sun 4:25 PM | Broncos @ 49ers | 49ers 31-17 | You are here |
| Sun 4:25 PM | Chiefs @ Raiders | Chiefs 27-24 | Read |
| Sun 4:25 PM | Chargers @ Seahawks | Seahawks 27-17 | Read |
| Sun 8:20 PM | Lions @ Panthers | Lions 31-24 | Read |
| Mon 8:15 PM | Falcons @ Saints | Saints 26-23 | Read |
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 4 game the same way. This one crosses the conferences, so the AFC Championship odds and the NFC Championship odds are both worth a look as the season develops.
Broncos vs 49ers FAQ
San Francisco, comfortably, at home. The 49ers are 3-0 with the best point differential in the league.
4:25 PM ET on Sunday 4 October, which is 3:25 PM CT and 1:25 PM PT.
CTV coverage is regional, so the fixture on your local CTV station depends where you are, with TSN alongside it and RDS in French. DAZN carries every game of the season in Canada.
No. They are the only team in the league yet to concede one.
19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change