Home » NFL News » Titans vs Colts Prediction, Picks & Odds

Titans vs Colts Prediction, Picks & Odds

Tennessee Titans vs Indianapolis Colts prediction, picks and odds for Week 6 of the 2026 NFL season

Fifty-eight points in five games. Tennessee have scored fewer than anyone in the NFL, and our Titans vs Colts prediction sends them to a defense that has conceded 15 touchdowns.

The Tennessee Titans are 0-5 and have been outscored by 51. The Indianapolis Colts are 2-3 and take fewer penalties than anyone, 25 for 164 yards. That discipline is what keeps ordinary teams in games.

Squawka Signal · Model vs market

Tennessee Titans @ Indianapolis Colts

Week 6 · Sun Oct 18, 1:00 PM ET. Our Signal model makes the Indianapolis Colts favorites by about 10 points, a 81% win probability.

TENTennessee TitansSquawka19%Market25%▼ Slight lay
INDIndianapolis ColtsSquawka81%Market75%▲ Value
Projected lineIndianapolis Colts -10
Against the spreadIndianapolis Colts -7 — model Indianapolis Colts -10 vs market Indianapolis Colts -7
ValueIndianapolis Colts — model 81% vs market 75%

Squawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.

Week 6 · Editorial pick

Titans vs Colts: our editor’s props

Two editorial selections to sit with the live Signal read below.

Titans AT Colts

Our props

TotalUnder 40.5 pointsTennessee have six touchdowns in five games and a 77.2 passer rating. Indianapolis rate 73.6 through the air, the second-lowest figure in the league.
★★★☆☆3/5 confidence
Player propJonathan Taylor 75+ rushing yardsTaylor has 398 rushing yards. Tennessee concede 3.54 a carry, which is respectable, but Indianapolis have no other route: they have thrown three touchdown passes all season.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.

Titans vs Colts: 2026 form so far

Two of the league’s least productive passing games, in the same building. The table measures each attack against what the opposite defense has conceded.

Titans attack against the Colts defense

Per gameTitans offenseColts allow
Passing yards163.8254.0
Rushing yards82.6130.2
Yards per carry3.85.0
Passer rating77.2103.4
Touchdowns1.23.0
Third-down conversion35.6%30.5%
Red-zone conversion46.2%62.5%
Sacks conceded / recorded2.02.0

Colts attack against the Titans defense

Per gameColts offenseTitans allow
Passing yards193.0217.8
Rushing yards100.8114.0
Yards per carry3.73.5
Passer rating73.6102.1
Touchdowns2.22.0
Third-down conversion35.3%38.5%
Red-zone conversion66.7%62.5%
Sacks conceded / recorded1.82.0

Figures are season to date, across 5 games.

Indianapolis have thrown three touchdown passes in five games and run for eight. That is a run-first team by necessity rather than design.

Titans vs Colts quarterback matchup

Tennessee rate 77.2 through the air and Indianapolis 73.6. Only the Chargers and Miami sit lower, and Miami are on bye.

TeamQuarterbackLast gameSeason to date
TitansCam Ward23/36, 181 yds, 1 TD, 1 INT, 74.0 rtg75/119, 726 yds, 3 TD, 2 INT, 81.4 rtg (4 games)
ColtsDaniel Jones24/36, 235 yds, 1 TD, 1 INT, 82.5 rtg84/132, 754 yds, 3 TD, 4 INT, 73.9 rtg (4 games)
Last game is Week 3. Season figures are 2026 to date, with games played in brackets.

Titans vs Colts injury report and team news

Jonathan Taylor has 398 rushing yards and Indianapolis have scored eight rushing touchdowns, against three through the air.

Indianapolis have taken 25 penalties for 164 yards, the fewest of any team in the NFL.

Tennessee have scored 58 points in five games, the lowest total in the league.

Injury report · Week 6Official game-status report — updates through the week
TENTennessee Titans
No game-status designations filed yet.
Out long-term
Joshua WilliamsCBIR
Kendell BrooksDBIR
Jaylen HarrellDEIR
Tanoh KpassagnonDEIR
Fernando Carmona Jr.GIR
Jackson SlaterGIR
Dominique HamptonLBIR
Dorian MausiLBIR
Milo EiflerLBIR
Jaren KanakTEIR
INDIndianapolis Colts
No game-status designations filed yet.
Out long-term
Cameron MitchellCBIR
Arden KeyDEIR
Micheal ClemonsDEIR
Carson TowtTEIR
Will MalloryTEIR
Alec PierceWRIR
D.J. MontgomeryWRIR

Two offenses that cannot throw

Indianapolis have three touchdown passes in five games. Tennessee have three. Between them that is six, and both teams rate below 78.0 as passing offenses.

So it falls to the ground game, and there Indianapolis have the edge. Jonathan Taylor’s 398 rushing yards and eight rushing touchdowns are doing almost all of the scoring for a team that has managed 124 points.

Tennessee’s defense is the reason this is not a blowout on paper. They concede 3.54 a carry and have allowed ten touchdowns, which is better than their record suggests.

Players to watch

  • Tony Pollard (TEN, RB): 273 rushing yards, the most dependable thing Tennessee have.
  • Carnell Tate (TEN, WR): A rookie target in an offense that has scored 58 points.
  • Jonathan Taylor (IND, RB): 398 rushing yards behind eight rushing touchdowns.
  • Tyler Warren (IND, TE): A central target in a passing game with three touchdowns.

How to watch Titans vs Colts

Kickoff is 1:00 PM ET on Sunday, October 18 at Lucas Oil Stadium, which is 12:00 PM CT and 10:00 AM PT. FOX has the regional broadcast.

DetailTitans vs Colts
DateSunday, October 18, 2026
Kickoff1:00 PM ET / 12:00 PM CT / 10:00 AM PT
VenueLucas Oil Stadium, Indianapolis, IN
TVFOX
Live streamNFL+ / Fubo
WeekWeek 6, 2026 NFL season

Titans vs Colts prediction and score projection

Indianapolis win 23-13. Neither team can throw, but only one has a back carrying the whole offense, and Tennessee have not scored more than 20 all season.

Signal’s live probability for this game updates as team news lands.

Every Week 6 game, previewed

Kickoff (ET)GameOur predictionPreview
Thu 8:15 PMSeahawks @ BroncosSeahawks 24-20Read
Sun 9:30 AMTexans @ JaguarsJaguars 27-17Read
Sun 1:00 PMRavens @ BrownsRavens 27-16Read
Sun 1:00 PMPanthers @ EaglesPanthers 24-20Read
Sun 1:00 PMBears @ FalconsBears 23-20Read
Sun 1:00 PMSaints @ GiantsGiants 26-20Read
Sun 1:00 PMJets @ PatriotsPatriots 24-17Read
Sun 1:00 PMSteelers @ BuccaneersSteelers 23-17Read
Sun 1:00 PMTitans @ ColtsColts 23-13You are here
Sun 4:05 PMCardinals @ RamsRams 30-20Read
Sun 4:25 PMBills @ RaidersBills 30-27Read
Sun 4:25 PMChargers @ ChiefsChiefs 31-13Read
Sun 8:20 PMCowboys @ PackersPackers 27-24Read
Mon 8:15 PMCommanders @ 49ers49ers 31-17Read

The rest of the round sits in this week’s Signal picks and our wider NFL analysis. The outright markets are priced in the Super Bowl market. For the player side of this game, see prop markets for this game.

Titans vs Colts FAQ

Who is favored, the Titans or the Colts?

Indianapolis, at home. The Colts are 2-3; Tennessee are 0-5 with a -51 point differential.

What time is Titans vs Colts?

1:00 PM ET on Sunday, October 18, at Lucas Oil Stadium.

Which team has scored the fewest points this season?

Tennessee, with 58 in five games, the lowest total in the NFL.

Which team takes the fewest penalties?

Indianapolis, with 25 for 164 yards, the fewest of any team in the league.

21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change