Our Cardinals vs 49ers prediction follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal’s live read updates on this page through the week.
The San Francisco 49ers have conceded no sacks in two games, converted 63.2% of their third downs and scored on 87.5% of their red-zone trips. The Arizona Cardinals managed 151 total yards at home against Seattle.
Arizona Cardinals @ San Francisco 49ers
Arizona CardinalsWin prob21%
San Francisco 49ersWin prob79%Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 18+. BeGambleAware.org. Please gamble responsibly. Full T&Cs & geo-restrictions apply: BoyleSports, bet365, Sky Bet.
Cardinals vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 18+ | BeGambleAware.org
Cardinals vs 49ers: 2026 form so far
One side converts nearly everything and the other converts almost nothing. The table sets each attack against what the opposite defence has allowed.
Cardinals attack against the 49ers defence
| Per game | Cardinals offence | 49ers allow |
|---|---|---|
| Passing yards | 179.0 | 175.0 |
| Rushing yards | 93.0 | 112.0 |
| Yards per carry | 3.6 | 3.9 |
| Passer rating | 86.2 | 80.9 |
| Touchdowns | 1.5 | 1.0 |
| Third-down conversion | 34.6% | 37.5% |
| Red-zone conversion | 50.0% | 20.0% |
| Sacks conceded / recorded | 1.5 | 2.0 |
49ers attack against the Cardinals defence
| Per game | 49ers offence | Cardinals allow |
|---|---|---|
| Passing yards | 246.0 | 203.0 |
| Rushing yards | 134.5 | 121.5 |
| Yards per carry | 4.7 | 4.0 |
| Passer rating | 125.6 | 110.9 |
| Touchdowns | 4.0 | 3.0 |
| Third-down conversion | 63.2% | 38.1% |
| Red-zone conversion | 87.5% | 62.5% |
| Sacks conceded / recorded | 0.0 | 2.0 |
Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.
San Francisco have not conceded a sack all season and score on seven of eight red-zone trips. Arizona have taken 14 penalties for 159 yards.
Cardinals vs 49ers injury report and team news
Brock Purdy completed 20 of 22 for 287 yards and two touchdowns against Miami at a 149.1 rating, and San Francisco scored on all five red-zone trips.
Jacoby Brissett completed 17 of 28 for 95 yards against Seattle as Arizona held the ball for 23:27.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Arizona CardinalsSan Francisco 49ersThe matchup that settles it: a quarterback nobody has touched
No sacks conceded in two games is why Purdy has completed 45 of 56 and thrown five touchdowns.
Arizona’s problem is everything in front of their own quarterback: 151 yards against Seattle, 3.2 a play, 23 and a half minutes of possession.
Trey McBride is the one route back, having caught eight for 41 and a touchdown in Week 2 against a defence that concedes little.
Players to watch
- Trey McBride (ARI, TE): Eight catches and a touchdown against Seattle.
- Jacoby Brissett (ARI, QB): 95 passing yards in Week 2, from 28 attempts.
- Brock Purdy (SF, QB): 287 yards and two touchdowns at a 149.1 rating against Miami.
- George Kittle (SF, TE): Four catches for 80 yards and a score in Week 2.
How to watch Cardinals vs 49ers
Kickoff is 9.05pm BST on Sunday, September 27, which is 4:05 PM ET in Santa Clara. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.
| Detail | Cardinals vs 49ers |
|---|---|
| Date | Sunday, September 27, 2026 |
| Kickoff | 9.05pm BST / Sunday 27 Sep |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | Sky Sports |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Cardinals vs 49ers prediction and score projection
Our Cardinals vs 49ers prediction is a San Francisco win, 30-13. The 49ers are efficient everywhere and Arizona could not move the ball at home last week.
The live win probability updates on this page through the week.
Every Week 3 game, previewed
| Kickoff (BST) | Game | Our prediction | Preview |
|---|---|---|---|
| Fri 1:15 AM | Falcons @ Packers | Packers 23-10 | Read |
| Sun 6:00 PM | Panthers @ Browns | Panthers 24-20 | Read |
| Sun 6:00 PM | Bengals @ Steelers | Bengals 20-13 | Read |
| Sun 6:00 PM | Texans @ Colts | Colts 26-20 | Read |
| Sun 6:00 PM | Chiefs @ Dolphins | Chiefs 31-17 | Read |
| Sun 6:00 PM | Chargers @ Bills | Bills 31-20 | Read |
| Sun 6:00 PM | Patriots @ Jaguars | Patriots 20-16 | Read |
| Sun 6:00 PM | Jets @ Lions | Lions 27-20 | Read |
| Sun 6:00 PM | Seahawks @ Commanders | Seahawks 27-17 | Read |
| Sun 6:00 PM | Titans @ Giants | Titans 20-17 | Read |
| Sun 9:05 PM | Cardinals @ 49ers | 49ers 30-13 | You are here |
| Sun 9:05 PM | Vikings @ Buccaneers | Vikings 20-17 | Read |
| Sun 9:25 PM | Ravens @ Cowboys | Ravens 30-24 | Read |
| Sun 9:25 PM | Raiders @ Saints | Raiders 24-20 | Read |
| Mon 1:20 AM | Rams @ Broncos | Rams 26-17 | Read |
| Tue 1:15 AM | Eagles @ Bears | Eagles 24-20 | Read |
Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.
Cardinals vs 49ers FAQ
San Francisco, at home and heavily. The 49ers are 2-0 with eight touchdowns; Arizona gained 151 yards last week.
9.05pm BST on Sunday, September 27, which is 4:05 PM ET.
Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION show two games free-to-air every Sunday, and those are not blacked out.
None in two games, which is a large part of why Purdy is completing 80% of his throws.
18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change