Arizona have conceded 21 touchdowns in five games, more than any team in the NFL, and traded Marvin Harrison Jr. to Houston on Sunday. Our Cardinals vs Rams prediction finds them at their lowest point of the season.
The Los Angeles Rams are 2-3 but have thrown for 1,538 yards, more than any team in the league. The Arizona Cardinals are 1-4 with a -54 point differential, the worst figure among the 28 teams playing this week.
Arizona Cardinals @ Los Angeles Rams
Arizona CardinalsSquawka16%Market13%▲ Value
Los Angeles RamsSquawka84%Market87%▼ Slight laySquawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.
Cardinals vs Rams: our editor’s props
Two editor’s calls on this game, alongside the live Signal numbers.
AT Our props
An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.
Cardinals vs Rams: 2026 form so far
The league’s most productive passing game against a secondary conceding a 117.3 rating. The table sets each attack against what the other defense has conceded.
Cardinals attack against the Rams defense
| Per game | Cardinals offense | Rams allow |
|---|---|---|
| Passing yards | 209.6 | 156.8 |
| Rushing yards | 91.6 | 128.4 |
| Yards per carry | 3.8 | 4.6 |
| Passer rating | 85.4 | 78.1 |
| Touchdowns | 2.4 | 2.6 |
| Third-down conversion | 40.5% | 32.8% |
| Red-zone conversion | 61.1% | 64.7% |
| Sacks conceded / recorded | 2.4 | 1.6 |
Rams attack against the Cardinals defense
| Per game | Rams offense | Cardinals allow |
|---|---|---|
| Passing yards | 307.6 | 236.8 |
| Rushing yards | 116.8 | 126.6 |
| Yards per carry | 4.6 | 4.4 |
| Passer rating | 88.2 | 117.3 |
| Touchdowns | 3.0 | 4.2 |
| Third-down conversion | 44.6% | 42.1% |
| Red-zone conversion | 65.0% | 76.5% |
| Sacks conceded / recorded | 1.4 | 2.2 |
Figures are season to date, across 5 games.
Twenty-one touchdowns conceded and a 117.3 opponent passer rating. Arizona have the worst pass defense in football, and the Rams throw more than anyone.
Cardinals vs Rams quarterback matchup
Los Angeles rate 88.2 through the air to Arizona’s 85.4, though the Rams have thrown 219 times to the Cardinals’ 200.
| Team | Quarterback | Last game | Season to date |
|---|---|---|---|
| Cardinals | Jacoby Brissett | 38/52, 280 yds, 2 TD, 0 INT, 98.2 rtg | 103/152, 818 yds, 6 TD, 4 INT, 83.2 rtg (4 games) |
| Rams | Matthew Stafford | 30/55, 390 yds, 2 TD, 2 INT, 74.1 rtg | 99/162, 1189 yds, 6 TD, 6 INT, 80.5 rtg (4 games) |
Cardinals vs Rams injury report and team news
Marvin Harrison Jr. was traded to Houston on 11 October and is no longer on the Arizona roster.
Los Angeles have thrown for 1,538 yards, more than any team in the NFL.
Arizona have conceded 21 touchdowns in five games, more than any other team.
Arizona CardinalsLos Angeles RamsThe worst pass defense in football
A 117.3 opponent passer rating, 14 touchdown passes conceded and 76.5% of red-zone trips finished against them. Arizona have conceded 21 touchdowns in all, more than any team in the league.
The Rams are the wrong opponent. Their 1,538 passing yards lead the league and Davante Adams has 441 of them, with Puka Nacua on 337 behind him.
Arizona lost Marvin Harrison Jr. on Sunday, which removes their best-known attacking player from a side that has been outscored by 54. Trey McBride’s 308 receiving yards now lead the team.
Players to watch
- Davante Adams (LA, WR): 441 receiving yards, sixth in the NFL.
- Kyren Williams (LA, RB): 343 rushing yards behind the league’s busiest passing game.
- Trey McBride (ARI, TE): 308 receiving yards, now Arizona’s leading target.
- Jeremiyah Love (ARI, RB): 245 rushing yards for a side outscored by 54.
How to watch Cardinals vs Rams
Kickoff is 4:05 PM ET on Sunday, October 18 at SoFi Stadium, which is 3:05 PM CT and 1:05 PM PT. FOX has the regional broadcast.
| Detail | Cardinals vs Rams |
|---|---|
| Date | Sunday, October 18, 2026 |
| Kickoff | 4:05 PM ET / 3:05 PM CT / 1:05 PM PT |
| Venue | SoFi Stadium, Inglewood, CA |
| TV | FOX |
| Live stream | NFL+ / Fubo |
| Week | Week 6, 2026 NFL season |
Cardinals vs Rams prediction and score projection
Los Angeles win 30-20. The Rams throw more than anyone and Arizona cannot stop it, and the Cardinals are a weaker team this week than last.
The live line and our projected margin both update through the week.
Every Week 6 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Seahawks @ Broncos | Seahawks 24-20 | Read |
| Sun 9:30 AM | Texans @ Jaguars | Jaguars 27-17 | Read |
| Sun 1:00 PM | Ravens @ Browns | Ravens 27-16 | Read |
| Sun 1:00 PM | Panthers @ Eagles | Panthers 24-20 | Read |
| Sun 1:00 PM | Bears @ Falcons | Bears 23-20 | Read |
| Sun 1:00 PM | Saints @ Giants | Giants 26-20 | Read |
| Sun 1:00 PM | Jets @ Patriots | Patriots 24-17 | Read |
| Sun 1:00 PM | Steelers @ Buccaneers | Steelers 23-17 | Read |
| Sun 1:00 PM | Titans @ Colts | Colts 23-13 | Read |
| Sun 4:05 PM | Cardinals @ Rams | Rams 30-20 | You are here |
| Sun 4:25 PM | Bills @ Raiders | Bills 30-27 | Read |
| Sun 4:25 PM | Chargers @ Chiefs | Chiefs 31-13 | Read |
| Sun 8:20 PM | Cowboys @ Packers | Packers 27-24 | Read |
| Mon 8:15 PM | Commanders @ 49ers | 49ers 31-17 | Read |
You can find our pick record alongside our NFL hub. The outright markets are priced in the NFC board. Player markets sit with prop markets for this game.
Cardinals vs Rams FAQ
Los Angeles, at home. The Rams are 2-3 at -1; Arizona are 1-4 at -54.
4:05 PM ET on Sunday, October 18, at SoFi Stadium.
No. He was traded to Houston on 11 October.
Arizona, conceding a 117.3 opponent passer rating — the worst in the NFL — and 21 touchdowns in total.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change