Our Chargers vs Bills prediction sends a stalling offence to the highest-scoring team in the league. Squawka Signal’s live read updates on this page through the week.
The Los Angeles Chargers have lost both games 26-14, to Arizona and then Las Vegas. The Buffalo Bills have scored 77 points in two games, more than anyone. One of those patterns is far easier to sustain.
Los Angeles Chargers @ Buffalo Bills
Los Angeles ChargersWin prob19%
Buffalo BillsWin prob81%Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 18+. BeGambleAware.org. Please gamble responsibly. Full T&Cs & geo-restrictions apply: BoyleSports, bet365, Sky Bet.
Chargers vs Bills: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 18+ | BeGambleAware.org
Chargers vs Bills: 2026 form so far
Two-and-oh against oh-and-two, and the underlying numbers offer the Chargers little comfort. The table sets each attack against what the other defence has allowed.
Chargers attack against the Bills defence
| Per game | Chargers offence | Bills allow |
|---|---|---|
| Passing yards | 185.0 | 273.0 |
| Rushing yards | 104.0 | 95.0 |
| Yards per carry | 3.9 | 3.7 |
| Passer rating | 71.6 | 118.4 |
| Touchdowns | 2.0 | 4.0 |
| Third-down conversion | 31.8% | 40.7% |
| Red-zone conversion | 80.0% | 77.8% |
| Sacks conceded / recorded | 3.0 | 3.5 |
Bills attack against the Chargers defence
| Per game | Bills offence | Chargers allow |
|---|---|---|
| Passing yards | 283.0 | 262.5 |
| Rushing yards | 144.5 | 86.5 |
| Yards per carry | 5.1 | 2.7 |
| Passer rating | 125.8 | 107.5 |
| Touchdowns | 5.0 | 2.5 |
| Third-down conversion | 57.1% | 35.7% |
| Red-zone conversion | 75.0% | 50.0% |
| Sacks conceded / recorded | 2.0 | 1.5 |
Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.
Buffalo are scoring on 75% of their red-zone trips and converting 57.1% on third down. The Chargers sit at 31.8% with three interceptions thrown.
Chargers vs Bills injury report and team news
Justin Herbert completed 15 of 27 for 192 with a touchdown and two interceptions against Las Vegas, and the Chargers gave the ball away three times.
Omarion Hampton carried 23 times for 94 yards and a touchdown, the busiest back on either side.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Los Angeles ChargersBuffalo BillsThe matchup that settles it: Buffalo’s red zone against a side averaging 14 points
Buffalo went five from five in the red zone against Detroit and converted nine of twelve third downs. That is complete control of their own possessions.
The Chargers have not been outclassed so much as stalled: 31.8% on third down, three interceptions, and an identical 26-14 defeat each week.
Buffalo are not stopping anybody either. They have conceded a 118.4 passer rating and Detroit put 31 on them while losing.
Players to watch
- Justin Herbert (LAC, QB): 192 yards, a touchdown and two interceptions against Las Vegas.
- Omarion Hampton (LAC, RB): 23 carries for 94 yards and a score in Week 2.
- Josh Allen (BUF, QB): Three passing touchdowns and two rushing against Detroit.
- James Cook III (BUF, RB): 135 rushing yards at 6.4 a carry in Week 2.
How to watch Chargers vs Bills
Kickoff is 6pm BST on Sunday, September 27, which is 1:00 PM ET in Orchard Park. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.
| Detail | Chargers vs Bills |
|---|---|
| Date | Sunday, September 27, 2026 |
| Kickoff | 6:00pm BST / 1:00 PM ET, Sunday 27 Sep |
| Venue | Highmark Stadium, Orchard Park, NY |
| TV | Sky Sports |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Chargers vs Bills prediction and score projection
Our Chargers vs Bills prediction is a Buffalo win, 31-20. The Bills score too freely for a side averaging 14 points to keep pace.
The live win probability updates on this page through the week.
Every Week 3 game, previewed
| Kickoff (BST) | Game | Our prediction | Preview |
|---|---|---|---|
| Fri 1:15 AM | Falcons @ Packers | Packers 23-10 | Read |
| Sun 6:00 PM | Panthers @ Browns | Panthers 24-20 | Read |
| Sun 6:00 PM | Bengals @ Steelers | Bengals 20-13 | Read |
| Sun 6:00 PM | Texans @ Colts | Colts 26-20 | Read |
| Sun 6:00 PM | Chiefs @ Dolphins | Chiefs 31-17 | Read |
| Sun 6:00 PM | Chargers @ Bills | Bills 31-20 | You are here |
| Sun 6:00 PM | Patriots @ Jaguars | Patriots 20-16 | Read |
| Sun 6:00 PM | Jets @ Lions | Lions 27-20 | Read |
| Sun 6:00 PM | Seahawks @ Commanders | Seahawks 27-17 | Read |
| Sun 6:00 PM | Titans @ Giants | Titans 20-17 | Read |
| Sun 9:05 PM | Cardinals @ 49ers | 49ers 30-13 | Read |
| Sun 9:05 PM | Vikings @ Buccaneers | Vikings 20-17 | Read |
| Sun 9:25 PM | Ravens @ Cowboys | Ravens 30-24 | Read |
| Sun 9:25 PM | Raiders @ Saints | Raiders 24-20 | Read |
| Mon 1:20 AM | Rams @ Broncos | Rams 26-17 | Read |
| Tue 1:15 AM | Eagles @ Bears | Eagles 24-20 | Read |
Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.
Chargers vs Bills FAQ
Buffalo, at home and comfortably. The Bills are 2-0 with 77 points; the Chargers are 0-2 with 28.
6pm BST on Sunday, September 27, which is 1:00 PM ET.
Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION show two games free-to-air every Sunday, and those are not blacked out.
Yes. Arizona beat them 26-14 and Las Vegas did the same a week later.
18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change