City could open a 12-point gap at the top of the table with what would be a 10th successive victory on home soil in all competitions.
More importantly, Pep Guardiola’s side are looking to get back to winning ways in the Premier League.
Indeed, their run of 12 straight wins was halted by a stubborn Southampton at St Mary’s last time out.
Nevertheless, history suggests that they will do just that here. After all, the Citizens have won each of their last 17 league matches on a Wednesday.
After a bright start to their maiden Premier League campaign, Brentford are now suffering a huge reality check, having lost their four most recent games.
You must go back to December 2007 for the last time they suffered five successive league defeats, though you feel it will take an almighty effort to avert that feat here.
The Bees’ cause to record an upset will be led by the in-form Ivan Toney, who could become the first Brentford player since November 1946 to score in three straight top-flight matches.
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Manchester City vs Brentford: Match Stats
It is fair to say that Kevin De Bruyne enjoys playing against newly promoted sides.
Indeed, Manchester City’s midfield maestro has been directly involved in 13 goals in 12 Premier League starts against such sides – scoring five and assisting eight.
The Belgium international has also found the net four times in his side’s last three league matches on home soil.
However, City have looked vulnerable defensively in recent times; keeping just two clean sheets in their last seven games.
Manchester City vs Brentford: Squawka Says
Scoreline prediction: Manchester City 3-1 Brentford