Our Dolphins vs 49ers prediction is the least competitive-looking fixture of the late window. Squawka Signal’s live read updates on this page through the week.
The San Francisco 49ers beat the Rams 27-7 without needing to force anything. The Miami Dolphins lost 27-13 at Las Vegas with five sacks conceded and 36 rushing yards from their lead back. It is a difficult trip to draw.
Dolphins vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 18+ | BeGambleAware.org
Dolphins vs 49ers: 2026 form so far
A 20-point win and a 14-point defeat, and the underlying numbers do not soften either.
| 2026 season to date | Dolphins | 49ers |
|---|---|---|
| Record | 0-1 | 1-0 |
| Points for | 13 | 27 |
| Points against | 27 | 7 |
| Point differential | -14 | +20 |
| Total yards | 259 | 379 |
| Yards per play | 5.2 | 5.9 |
| Turnovers | 2 | 1 |
| Third-down offence | 20.0% | 58.3% |
| Red-zone offence | 33.3% | 66.7% |
| Sacks recorded | 0 | 0 |
| Opponent passer rating | 88.2 | 62.8 |
San Francisco converted 58.3% of third downs without recording a sack. Miami converted 20% and gave up five.
Dolphins vs 49ers injury report and team news
Malik Willis completed 15 of 27 at a 66.9 rating and was sacked five times. De’Von Achane carried 11 times for 36 yards.
This section updates as soon as the Out, Doubtful and Questionable tags land.
The matchup that settles it: Miami’s protection against a front that barely had to try
Five sacks conceded at Las Vegas is the immediate problem, and San Francisco beat the Rams by 20 without registering one of their own.
Brock Purdy threw three touchdowns from 34 attempts and Christian McCaffrey averaged 6.8 a carry. Nothing about that afternoon was strained.
Miami did force two interceptions at Las Vegas, so a route into the game exists. They also conceded three touchdown passes in the same afternoon.
Players to watch
- Malik Willis (MIA, QB): 220 yards, no touchdowns and five sacks taken at Las Vegas.
- De’Von Achane (MIA, RB): 11 carries for 36 yards in the opener.
- Brock Purdy (SF, QB): Three touchdown passes at a 105.6 rating against the Rams.
- Christian McCaffrey (SF, RB): Ten carries for 68 yards at 6.8 a carry.
How to watch Dolphins vs 49ers
Kickoff is 9.25pm BST on Sunday, September 20, which is 4:25 PM ET in Santa Clara. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky takes one exclusive pick from each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Squawka may earn a commission if you subscribe through that link.
| Detail | Dolphins vs 49ers |
|---|---|
| Date | Sunday, September 20, 2026 |
| Kickoff | 9:25pm BST / Sunday 20 Sep |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | Sky Sports |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Dolphins vs 49ers prediction and score projection
Our Dolphins vs 49ers prediction is a San Francisco win, 27-13. The 49ers are the more complete side and Miami’s line is a problem.
The live win probability updates on this page through the week.
Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.
Dolphins vs 49ers FAQ
San Francisco, at home and heavily. The 49ers won by 20 in Week 1 while Miami lost by 14.
9.25pm BST on Sunday, September 20, which is 4:25 PM ET.
Sky Sports has the coverage and NFL Game Pass on DAZN carries every game of the season, live or on demand. Sky holds one exclusive pick in each of the Sunday 6pm and 9pm windows, and those two reach Game Pass 24 hours after the final whistle. Channel 5 and 5ACTION show two games free-to-air every Sunday, and those are not blacked out.
Miami lost 27-13 at Las Vegas. San Francisco beat the Rams 27-7.
18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change