San Francisco is 5-0 with a +61 point differential, the best in football, and has conceded three sacks all season. Our Commanders vs 49ers prediction closes Week 6 on Monday night.
The Washington Commanders are 1-3-1 after last week’s tie and concede on 83.3% of opponent red-zone trips, the worst rate in the NFL. The San Francisco 49ers convert 87.5% of their own, the best.
Commanders vs 49ers: our editor’s props
Two editor’s calls on this game, alongside the live Signal numbers.
AT 
Our props
An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.
Commanders vs 49ers: 2026 form so far
The best team in the league against the worst red-zone defence in it. The table weighs what each team produces against what the other keeps giving up.
Commanders attack against the 49ers defence
| Per game | Commanders offence | 49ers allow |
|---|---|---|
| Passing yards | 187.8 | 199.6 |
| Rushing yards | 139.6 | 97.6 |
| Yards per carry | 4.7 | 3.7 |
| Passer rating | 90.2 | 83.4 |
| Touchdowns | 2.6 | 1.6 |
| Third-down conversion | 31.9% | 40.8% |
| Red-zone conversion | 50.0% | 50.0% |
| Sacks conceded / recorded | 2.0 | 2.2 |
49ers attack against the Commanders defence
| Per game | 49ers offence | Commanders allow |
|---|---|---|
| Passing yards | 236.4 | 255.0 |
| Rushing yards | 128.6 | 95.4 |
| Yards per carry | 4.6 | 3.9 |
| Passer rating | 119.3 | 103.9 |
| Touchdowns | 4.0 | 3.4 |
| Third-down conversion | 51.9% | 43.3% |
| Red-zone conversion | 87.5% | 83.3% |
| Sacks conceded / recorded | 0.6 | 1.8 |
Figures are season to date, across 5 games.
Three sacks conceded in five games is the lowest figure in the NFL, and San Francisco had given up none at all until Week 5.
Commanders vs 49ers quarterback matchup
A 119.3 team passer rating is the best in football, and the protection in front of it is the quieter reason why.
| Team | Quarterback | Last game | Season to date |
|---|---|---|---|
| Commanders | Marcus Mariota | 19/31, 183 yds, 3 TD, 0 INT, 110.0 rtg | 33/51, 340 yds, 4 TD, 0 INT, 109.9 rtg (3 games) |
| 49ers | Brock Purdy | 15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg | 79/113, 1007 yds, 11 TD, 1 INT, 126.2 rtg (4 games) |
Commanders vs 49ers injury report and team news
San Francisco has conceded three sacks in five games, the fewest in the NFL.
Washington concedes on 83.3% of opponent red-zone trips, the worst rate in the league.
Washington drew 27-27 with the Giants in Week 5 and its quarterback room will be confirmed on Friday.
The best team in football, on Monday night
Five and oh, plus 61, and 154 points. San Francisco leads the league on differential and sits second on points, and a 119.3 team passer rating is the best in football.
The offensive line is the quieter story. Three sacks conceded in five games is the lowest figure in the NFL, and the 49ers had given up none at all until Week 5.
Washington’s red-zone defence is the worst in the league at 83.3% conceded, which against an attack converting 87.5% of its own trips is the matchup that decides how lopsided this gets.
Players to watch
- Christian McCaffrey (SF, RB): 286 on the ground behind the best pass protection going.
- Mike Evans (SF, WR): 326 receiving yards in an attack rating 119.3.
- Terry McLaurin (WAS, WR): A senior target for a team that has given up 149 points.
- Jacory Croskey-Merritt (WAS, RB): 239 rushing yards in a team running at 4.72 a carry.
How to watch Commanders vs 49ers in Canada
Kickoff is 8:15 PM ET on Monday, October 19 at Levi’s Stadium in Santa Clara. TSN carries it nationally, because every primetime window in Canada sits with TSN, and RDS has the French-language broadcast. DAZN carries every game of the season in Canada through NFL Game Pass. Squawka may earn a commission if you subscribe through that link.
| Detail | Commanders vs 49ers |
|---|---|
| Date | Monday, October 19, 2026 |
| Kickoff | 8:15 PM ET / 7:15 PM CT / 5:15 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | TSN (English) / RDS (French) |
| Live stream | DAZN (NFL Game Pass) |
| Week | Week 6, 2026 NFL season |
Commanders vs 49ers prediction and score projection
Our Commanders vs 49ers prediction is San Francisco by 31-17. The 49ers are the best team in the league and Washington’s red-zone defence is the softest they will face.
Signal’s live probability and the current market number update through to kickoff.
Every Week 6 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Seahawks @ Broncos | Seahawks 24-20 | Read |
| Sun 9:30 AM | Texans @ Jaguars | Jaguars 27-17 | Read |
| Sun 1:00 PM | Ravens @ Browns | Ravens 27-16 | Read |
| Sun 1:00 PM | Panthers @ Eagles | Panthers 24-20 | Read |
| Sun 1:00 PM | Bears @ Falcons | Bears 23-20 | Read |
| Sun 1:00 PM | Saints @ Giants | Giants 26-20 | Read |
| Sun 1:00 PM | Jets @ Patriots | Patriots 24-17 | Read |
| Sun 1:00 PM | Steelers @ Buccaneers | Steelers 23-17 | Read |
| Sun 1:00 PM | Titans @ Colts | Colts 23-13 | Read |
| Sun 4:05 PM | Cardinals @ Rams | Rams 30-20 | Read |
| Sun 4:25 PM | Bills @ Raiders | Bills 30-27 | Read |
| Sun 4:25 PM | Chargers @ Chiefs | Chiefs 31-13 | Read |
| Sun 8:20 PM | Cowboys @ Packers | Packers 27-24 | Read |
| Mon 8:15 PM | Commanders @ 49ers | 49ers 31-17 | You are here |
The rest of the week is covered across our NFL hub, and Signal rates every Week 6 game the same way. Both these teams are chasing the NFC Championship odds, with the AFC Championship odds tracked alongside them through the season.
Commanders vs 49ers FAQ
San Francisco, heavily. The 49ers are 5-0 at +61; Washington is 1-3-1.
8:15 PM ET on Monday, October 19, which is 7:15 PM CT and 5:15 PM PT, at Levi’s Stadium.
TSN carries every primetime window nationally, with RDS on the French-language broadcast. DAZN carries every game of the season in Canada through NFL Game Pass.
Three in five games, the fewest in the NFL.
19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change