Our Cardinals vs 49ers prediction is the most one-sided read of the late afternoon. Squawka Signal’s live read updates on this page through the week.
The Arizona Cardinals gained 151 yards at home against Seattle and held the ball for under 24 minutes. The San Francisco 49ers are scoring on 87.5% of their red-zone trips. The divisional tie does little to close that.
Arizona Cardinals @ San Francisco 49ers
Arizona CardinalsWin prob21%
San Francisco 49ersWin prob79%Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 19+ (18+ in AB/MB/QC). Please play responsibly. ConnexOntario: 1-866-531-2600 (ON). Full T&Cs & geo-restrictions apply: bet365.
Cardinals vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.
Cardinals vs 49ers: 2026 form so far
An unbeaten side against one that has just been dismantled at home. Each attack is set against what the opposite defence has allowed.
Cardinals attack against the 49ers defence
| Per game | Cardinals offence | 49ers allow |
|---|---|---|
| Passing yards | 179.0 | 175.0 |
| Rushing yards | 93.0 | 112.0 |
| Yards per carry | 3.6 | 3.9 |
| Passer rating | 86.2 | 80.9 |
| Touchdowns | 1.5 | 1.0 |
| Third-down conversion | 34.6% | 37.5% |
| Red-zone conversion | 50.0% | 20.0% |
| Sacks conceded / recorded | 1.5 | 2.0 |
49ers attack against the Cardinals defence
| Per game | 49ers offence | Cardinals allow |
|---|---|---|
| Passing yards | 246.0 | 203.0 |
| Rushing yards | 134.5 | 121.5 |
| Yards per carry | 4.7 | 4.0 |
| Passer rating | 125.6 | 110.9 |
| Touchdowns | 4.0 | 3.0 |
| Third-down conversion | 63.2% | 38.1% |
| Red-zone conversion | 87.5% | 62.5% |
| Sacks conceded / recorded | 0.0 | 2.0 |
Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.
San Francisco convert 63.2% on third down. Arizona convert 34.6% and have conceded a 110.9 passer rating.
Cardinals vs 49ers injury report and team news
George Kittle caught four passes for 80 yards and a touchdown against Miami.
Arizona have taken 14 penalties for 159 yards in two games, among the heaviest totals in the league.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Arizona CardinalsSan Francisco 49ersThe matchup that settles it: San Francisco’s third-down rate
Sixty-three per cent on third down keeps drives alive and keeps Arizona’s offence watching, which is exactly what happened to the Cardinals against Seattle.
Arizona’s best hope is Trey McBride, their most targeted player and the only one producing consistently.
San Francisco have conceded two touchdowns in two games and hold opponents to 20% in the red zone.
Players to watch
- Trey McBride (ARI, TE): Eight catches and a touchdown against Seattle.
- Jacoby Brissett (ARI, QB): 95 passing yards in Week 2, from 28 attempts.
- Brock Purdy (SF, QB): 287 yards and two touchdowns at a 149.1 rating against Miami.
- George Kittle (SF, TE): Four catches for 80 yards and a score in Week 2.
How to watch Cardinals vs 49ers
The game kicks off at 4:05 PM ET on Sunday, September 27, which is 3:05 PM CT and 1:05 PM PT. CTV has the regional broadcast and RDS the French-language call, and DAZN carries every game of the season. Squawka may earn a commission if you subscribe through that link.
| Detail | Cardinals vs 49ers |
|---|---|
| Date | Sunday, September 27, 2026 |
| Kickoff | 4:05 PM ET / 3:05 PM CT / 1:05 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | CTV (regional) / RDS (French) |
| Live stream | DAZN (NFL Game Pass) / CTV.ca |
| Week | Week 2, 2026 NFL season |
Cardinals vs 49ers prediction and score projection
Our Cardinals vs 49ers prediction is a San Francisco win, 30-13. The 49ers are the better side in every phase.
Signal’s live number updates on this page through the week.
Every Week 3 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Falcons @ Packers | Packers 23-10 | Read |
| Sun 1:00 PM | Panthers @ Browns | Panthers 24-20 | Read |
| Sun 1:00 PM | Bengals @ Steelers | Bengals 20-13 | Read |
| Sun 1:00 PM | Texans @ Colts | Colts 26-20 | Read |
| Sun 1:00 PM | Chiefs @ Dolphins | Chiefs 31-17 | Read |
| Sun 1:00 PM | Chargers @ Bills | Bills 31-20 | Read |
| Sun 1:00 PM | Patriots @ Jaguars | Patriots 20-16 | Read |
| Sun 1:00 PM | Jets @ Lions | Lions 27-20 | Read |
| Sun 1:00 PM | Seahawks @ Commanders | Seahawks 27-17 | Read |
| Sun 1:00 PM | Titans @ Giants | Titans 20-17 | Read |
| Sun 4:05 PM | Cardinals @ 49ers | 49ers 30-13 | You are here |
| Sun 4:05 PM | Vikings @ Buccaneers | Vikings 20-17 | Read |
| Sun 4:25 PM | Ravens @ Cowboys | Ravens 30-24 | Read |
| Sun 4:25 PM | Raiders @ Saints | Raiders 24-20 | Read |
| Sun 8:20 PM | Rams @ Broncos | Rams 26-17 | Read |
| Mon 8:15 PM | Eagles @ Bears | Eagles 24-20 | Read |
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 3 game the same way. Compare the AFC Championship odds and NFC Championship odds as the season develops, and our guide to watching the NFL in Canada covers every window.
Cardinals vs 49ers FAQ
San Francisco, at home. The 49ers are 2-0 and have conceded two touchdowns.
4:05 PM ET on Sunday, September 27, which is 3:05 PM CT and 1:05 PM PT.
CTV has the regional broadcast and RDS the French. DAZN streams it too.
Arizona lost 31-7 at home to Seattle. San Francisco beat Miami 35-13.
19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change