San Francisco have not allowed a sack all season. They are the only team in the NFL who can say that, and our 49ers vs Seahawks prediction sends them to the loudest stadium in the league to defend it.
This is the game of the week. The San Francisco 49ers are 4-0 with a +58 point differential, the best in football. The Seattle Seahawks are 3-1 and have conceded 579 passing yards, fewer than anyone else. Something has to give at Lumen Field.
49ers vs Seahawks: our editor’s props
Two editor’s calls on this game, alongside the live Signal numbers.
AT 
Our props
An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.
49ers vs Seahawks: 2026 form so far
The best record in football against the best pass defense. The table measures each attack against what the opposing side has actually conceded.
49ers attack against the Seahawks defense
| Per game | 49ers offense | Seahawks allow |
|---|---|---|
| Passing yards | 251.8 | 144.8 |
| Rushing yards | 137.2 | 102.0 |
| Yards per carry | 4.8 | 3.6 |
| Passer rating | 126.2 | 72.1 |
| Touchdowns | 4.0 | 2.0 |
| Third-down conversion | 57.5% | 28.6% |
| Red-zone conversion | 84.6% | 66.7% |
| Sacks conceded / recorded | 0.0 | 2.8 |
Seahawks attack against the 49ers defense
| Per game | Seahawks offense | 49ers allow |
|---|---|---|
| Passing yards | 237.0 | 209.0 |
| Rushing yards | 110.2 | 99.8 |
| Yards per carry | 3.9 | 3.7 |
| Passer rating | 112.1 | 87.1 |
| Touchdowns | 3.2 | 1.5 |
| Third-down conversion | 31.1% | 44.1% |
| Red-zone conversion | 56.2% | 45.5% |
| Sacks conceded / recorded | 1.5 | 1.5 |
Figures are season to date, across 4 games.
Zero sacks allowed in four games and 113 pass attempts. No other team in the league is on fewer than five, and Seattle’s eleven sacks make this the matchup the game turns on.
49ers vs Seahawks quarterback matchup
San Francisco’s 126.2 team passer rating is the highest in the league, and Seattle’s 112.1 is third. This is the best quarterback matchup on the card.
| Team | Quarterback | Last game | Season to date |
|---|---|---|---|
| 49ers | Brock Purdy | 15/27, 297 yds, 4 TD, 0 INT, 133.8 rtg | 79/113, 1007 yds, 11 TD, 1 INT, 126.2 rtg (4 games) |
| Seahawks | Sam Darnold | 31/45, 379 yds, 4 TD, 2 INT, 105.7 rtg | 45/69, 560 yds, 6 TD, 3 INT, 101.1 rtg (3 games) |
49ers vs Seahawks injury report and team news
San Francisco’s receiving room has been thinned by injury, with Ricky Pearsall and Christian Kirk both on injured reserve. Mike Evans and Brandin Cooks have taken on the load alongside George Kittle.
Zach Charbonnet is on injured reserve for Seattle, leaving the backfield to Emanuel Wilson and George Holani.
Seattle have conceded 579 passing yards, the fewest of any team in the NFL.
Zero sacks against eleven
Start with the protection. San Francisco have given up nothing in 113 attempts, which is why Brock Purdy has eleven touchdown passes and a 126.2 rating, both at or near the top of the league. Clean pockets have produced the best offense in football.
Seattle are the first side equipped to break it. Eleven sacks, a 72.1 opponent passer rating that only Minnesota better, and 28.6% allowed on third down. Lumen Field has historically been worth a false start or two as well.
The 49ers have one genuine vulnerability and it is personnel. With Pearsall and Kirk on injured reserve, the receiving group leans on Mike Evans, Brandin Cooks and Kittle. Against a secondary this good, that is a narrower set of answers than San Francisco have needed so far.
Players to watch
- George Kittle (SF, TE): 244 receiving yards, and the most reliable target in a thinned receiving group.
- Christian McCaffrey (SF, RB): 218 rushing yards behind a line that has conceded no sacks.
- Jaxon Smith-Njigba (SEA, WR): 481 receiving yards from 32 catches, third in the NFL.
- Cooper Kupp (SEA, WR): A second target in a passing game rating 112.1.
How to watch 49ers vs Seahawks
Kickoff is 4:25 PM ET on Sunday, October 11 at Lumen Field, which is 3:25 PM CT and 1:25 PM PT. FOX has the national broadcast.
| Detail | 49ers vs Seahawks |
|---|---|
| Date | Sunday, October 11, 2026 |
| Kickoff | 4:25 PM ET / 3:25 PM CT / 1:25 PM PT |
| Venue | Lumen Field, Seattle, WA |
| TV | FOX |
| Live stream | NFL+ / Fubo |
| Week | Week 5, 2026 NFL season |
49ers vs Seahawks prediction and score projection
Seattle win 24-21. This is the upset call of the week: the Seahawks have the pass defense to make San Francisco uncomfortable for the first time, and Lumen Field does the rest.
The model’s number and the live market price for this game both update through the week.
Every Week 5 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Buccaneers @ Cowboys | Cowboys 27-20 | Read |
| Sun 9:30 AM | Eagles @ Jaguars | Jaguars 24-17 | Read |
| Sun 1:00 PM | Bears @ Packers | Bears 24-20 | Read |
| Sun 1:00 PM | Bengals @ Dolphins | Bengals 27-16 | Read |
| Sun 1:00 PM | Browns @ Jets | Browns 20-17 | Read |
| Sun 1:00 PM | Texans @ Titans | Texans 19-16 | Read |
| Sun 1:00 PM | Colts @ Steelers | Steelers 21-20 | Read |
| Sun 1:00 PM | Raiders @ Patriots | Raiders 23-20 | Read |
| Sun 1:00 PM | Vikings @ Saints | Vikings 26-17 | Read |
| Sun 1:00 PM | Giants @ Commanders | Giants 24-17 | Read |
| Sun 4:05 PM | Broncos @ Chargers | Broncos 23-17 | Read |
| Sun 4:25 PM | Lions @ Cardinals | Lions 27-20 | Read |
| Sun 4:25 PM | 49ers @ Seahawks | Seahawks 24-21 | You are here |
| Sun 8:20 PM | Ravens @ Falcons | Ravens 26-20 | Read |
| Mon 8:15 PM | Bills @ Rams | Bills 27-23 | Read |
NFL predictions for the round and our NFL betting coverage carry the rest of the card. The outright markets are priced in the NFC board. We price the player markets in prop markets for this game.
49ers vs Seahawks FAQ
San Francisco on form, at 4-0 with the best point differential in the NFL. Seattle are 3-1 and at home.
4:25 PM ET on Sunday, October 11, at Lumen Field.
No sacks in four games and 113 pass attempts. They are the only team in the NFL yet to allow one.
They have conceded 579 passing yards, the fewest in the league, at a 72.1 opponent rating.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change