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Squawka / News / Liverpool vs Atletico Madrid predictions and betting tips: Reds fancied at Anfield

Liverpool vs Atletico Madrid predictions and betting tips: Reds fancied at Anfield

Liverpool vs Atletico Madrid is a Champions League heavyweight opener at Anfield on Wednesday, with the hosts fancied.

Andy Francis has the best bets, a score prediction and the head-to-head record for this Champions League clash below.

Premium Tips

Andy is with Liverpool, who should harness a raucous Anfield.

Premium TipOddsWhy we’re backing it
Liverpool to win and over 3.5 goals13/5Andoni Iraola’s Liverpool light up Anfield and their recent games have been packed with goals, drawing 2-2 with Nottingham Forest and 2-2 at Newcastle before a 2-0 win at Ipswich. Atletico Madrid arrive having leaked in most of their outings, including a 3-0 loss at Athletic Club and a 2-2 home draw with Villarreal, so they are not watertight. That points to an open, entertaining night under the lights. With Liverpool’s firepower expected to carry them to the win and both sides capable of finding the net, the goals should flow, making over 3.5 a live shout at Anfield.
Alexander Isak and Ademola Lookman to score anytime8/1Isak is a genuine elite finisher, with 64 goals in 110 games during his Newcastle days and already off the mark at Liverpool with seven strikes. Leading the line at Anfield, he should get clear sights of goal against an Atletico defence that has been creaking. Lookman is no passenger either, boasting 52 goals in 137 appearances for Atalanta plus seven since his Atletico switch, and he carries a real threat on the counter. Both are proven match-winners who love to shoot, and in a game expected to produce goals, backing this pair to score makes plenty of sense.

18+ only. Please gamble responsibly. GambleAware — gambleaware.org · Odds correct at time of publishing.

How Liverpool go into the game

Liverpool won 2-0 at Ipswich last time out and welcome Atletico to a raucous Anfield. The European nights are made for the Reds.

Loaded with quality and ruthless at home, Liverpool are among the favourites. A strong start is the aim.

How Atletico Madrid go into the game

Atletico Madrid were hammered 3-0 at Athletic Club last time out, a chastening afternoon. They travel to Anfield needing a response.

Well-drilled and stubborn on their day, Atleti carry a threat but face a huge test in poor form.

Liverpool vs Atletico Madrid: 2025-26 by the numbers

Liverpool vs Atletico Madrid head-to-head

DateHomeScoreAway
17/09/25Liverpool3-2Atlético Madrid
03/11/21Liverpool2-0Atlético Madrid
19/10/21Atlético Madrid2-3Liverpool
11/03/20Liverpool1-0Atlético Madrid
18/02/20Atlético Madrid1-0Liverpool

Liverpool have dominated the recent series, winning four of the five Champions League meetings.

Liverpool vs Atletico Madrid predictions & betting tips

Our PredictionOdds & BookmakerConfidenceWhy We’re Backing It
Liverpool to win4/6⭐⭐⭐Formidable at Anfield.
Liverpool or draw (Double Chance)2/11⭐⭐⭐Strong home cover.
Over 2.5 goals8/13⭐⭐Goals expected.
Both teams to score8/13⭐⭐Both carry a threat.
Liverpool 3-2 Atletico Madrid14/1⭐⭐Headline scoreline.

Liverpool vs Atletico Madrid score prediction

Atletico carry a threat, but Liverpool’s quality and Anfield should tell. Expect the hosts to edge a big one. Score prediction: Liverpool 2-1 Atletico Madrid.

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