49ers vs Cowboys Prediction, Picks & Odds

San Francisco scores 3.9 touchdowns a game and converts 84.6% in the red zone, both league bests. Dallas concedes 48.3% on third down, the worst mark in the NFL. Our 49ers vs Cowboys prediction sets the best offence in football against its most generous defence.

The San Francisco 49ers are 7-1 at +79. The Dallas Cowboys are 4-5 and have given up 236 points in nine games.

Week 10 · Editorial pick

49ers vs Cowboys: our editor’s props

Two editorial selections to sit with the live Signal read below.

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Our props

Player propSan Francisco 3+ touchdownsThe 49ers score 3.9 a game and convert 84.6% in the red zone, both NFL bests. Dallas gives up 3.0.

★★★★☆4/5 confidence

Player propDak Prescott 250+ passing yardsThe Cowboys throw for 257 a game and Prescott had 335 last week. San Francisco allows 211.

★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.

49ers vs Cowboys: 2026 form so far

The league’s best offence visiting a defence that cannot get a stop. The columns put each team’s output next to what the other has conceded to date.

49ers attack against the Cowboys defence

Cowboys attack against the 49ers defence

The Cowboys concede 48.3% on third down, the highest rate in the NFL, and 147 rushing yards a game, 31st.

49ers vs Cowboys quarterback matchup

Brock Purdy threw for 232 yards and two scores at a 107.4 rating in a 38-17 win. Dak Prescott completed 21 of 34 for 335 and two touchdowns at 114.2.

49ers vs Cowboys injury report and team news

San Francisco scores 3.9 touchdowns a game and converts 84.6% in the red zone, both NFL bests.

Dallas concedes 48.3% on third down, the worst rate in the league.

The 49ers give up 3.33 yards a carry and 81 rushing yards a game, both league bests.

The best offence in football against the most generous third down

San Francisco is 7-1 and the attack is remarkably efficient: 3.9 touchdowns a game and 84.6% in the red zone lead the league, with 51.7% on third down second.

The defence matches it. Opponents gain 3.33 yards a carry and 81 rushing yards a game, the best marks in football, and score 1.9 touchdowns.

Dallas scores plenty at 3.1 touchdowns a game and 71.4% in the red zone, third in the league. Getting a stop is the issue: 48.3% on third down and 147 rushing yards conceded.

Players to watch

• Brock Purdy (SF, QB): Rates 109.8 in an attack converting 84.6% in the red zone.
• George Kittle (SF, TE): Primary target in the league’s most efficient attack.
• Dak Prescott (DAL, QB): Threw for 335 yards and two scores at 114.2 last week.
• CeeDee Lamb (DAL, WR): Led the Cowboys receivers in the win over Indianapolis.

How to watch 49ers vs Cowboys in Canada

Kickoff is 4:25 PM ET on Sunday, November 15 at AT&T Stadium in Arlington. Which Sunday afternoon game CTV shows depends on where you are watching, so check locally. RDS has the French call. DAZN carries every game of the season in Canada through NFL Game Pass. Squawka may earn a commission if you subscribe through that link.

49ers vs Cowboys prediction and score projection

Our 49ers vs Cowboys prediction is San Francisco by 34-24. Dallas will put up points, as it always does, and 48.3% conceded on third down against this attack does not hold.

Signal’s live read on this game updates through the week.

Every Week 10 game, previewed

You can find the other games on our NFL hub, with Signal’s read on all of Week 10 alongside them. Two NFC teams, which puts the NFC Championship odds in play rather than the AFC Championship odds — though both are tracked together.

49ers vs Cowboys FAQ

19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change