Our Colts vs Chiefs prediction favors Kansas City on Sunday night, and the running games are why. Squawka Signal’s live read on this game, including where the value sits, updates on this page through the week.
The Kansas City Chiefs beat Denver 31-10 on Monday with 220 rushing yards. The Indianapolis Colts lost 41-23 at home to Baltimore, conceding 202 on the ground and four rushing touchdowns. Consequently the same weakness is about to be tested again.
Indianapolis Colts @ Kansas City Chiefs
Indianapolis ColtsSquawka30%Market26%▲ Value
Kansas City ChiefsSquawka70%Market74%▼ Slight laySquawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.
Colts vs Chiefs: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
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Colts vs Chiefs: 2026 form so far
One game each, and the tables point the same way. Kansas City controlled their opener; Indianapolis were run over in theirs.
| 2026 season to date | Colts | Chiefs |
|---|---|---|
| Record | 0-1 | 1-0 |
| Points for | 23 | 31 |
| Points against | 41 | 10 |
| Point differential | -18 | +21 |
| Total yards | 251 | 392 |
| Yards per play | 4.7 | 5.9 |
| Turnovers | 2 | 1 |
| Third-down offense | 30.0% | 52.9% |
| Red-zone offense | 100.0% | 60.0% |
| Sacks recorded | 2 | 4 |
| Opponent passer rating | 124.2 | 69.2 |
Kansas City converted 52.9% of third downs and held the ball for almost 34 minutes. Indianapolis conceded a 124.2 passer rating, the highest figure of their weekend.
Colts vs Chiefs injury report and team news
Kenneth Walker carried 23 times for 173 yards against Denver, the highest rushing total of the opening week. Patrick Mahomes threw for 184 at an 86.0 rating.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Indianapolis ColtsKansas City ChiefsWhere Colts vs Chiefs is decided
Kansas City ran 38 times on Monday and did not need Patrick Mahomes to be excellent. Indianapolis have already conceded four rushing touchdowns in a single afternoon.
Jonathan Taylor is the Colts’ route back into it. He averaged 5.2 a carry against Baltimore and scored twice, which is more than Denver managed all night.
Kansas City’s defense recorded four sacks and an interception against Denver. Nevertheless Daniel Jones is a more mobile problem than Bo Nix proved to be.
Players to watch
- Jonathan Taylor (IND, RB): 19 carries for 98 yards and two touchdowns against Baltimore.
- Daniel Jones (IND, QB): 166 yards and a touchdown in the opener, with one interception.
- Kenneth Walker (KC, RB): 173 rushing yards at 7.5 a carry against Denver.
- Patrick Mahomes (KC, QB): Two touchdown passes on Monday night, from 27 attempts.
How to watch Colts vs Chiefs
The game kicks off at 8:20 PM ET on Sunday, September 20 at Arrowhead Stadium in Kansas City. NBC and Peacock carry it. It is the Sunday night game, so it stands alone.
| Detail | Colts vs Chiefs |
|---|---|
| Date | Sunday, September 20, 2026 |
| Kickoff | 8:20 PM ET / 7:20 PM CT / 5:20 PM PT |
| Venue | Arrowhead Stadium, Kansas City, MO |
| TV | NBC/Peacock |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Colts vs Chiefs prediction and score projection
Our Colts vs Chiefs prediction is a Kansas City win, 30-20. The Chiefs can run it, and Indianapolis have already shown they struggle to stop anyone doing so.
That is our call; Signal’s live figure updates on this page through the week.
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 2 game the same way.
Colts vs Chiefs FAQ
Kansas City, at home. The Chiefs opened with a 31-10 win at Arrowhead; Indianapolis lost 41-23 to Baltimore.
8:20 PM ET on Sunday, September 20, which is 7:20 PM CT and 5:20 PM PT.
NBC and Peacock have the game in the United States.
Kansas City beat Denver 31-10 on Monday night. Indianapolis lost 41-23 at home to Baltimore.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change