Our Cardinals vs Chargers prediction backs Los Angeles clearly, in a 9.25pm BST kickoff that is the other genuinely watchable slot of the 2026 NFL season opening Sunday from Britain. Squawka Signal’s live read on this game, including where the value sits, is in the block just below.
Los Angeles finished 11-6 and reached the postseason; Arizona went 3-14 and lost their final nine, the longest losing run carried into this weekend. The Chargers held opponents to a 75.0 passer rating, the best mark in the round.
Cardinals vs Chargers: our editor’s prop
One editorial call to sit alongside the live Signal numbers above.
AT 
Our prop
An editorial call, not a Signal model output. 18+ | BeGambleAware.org
Cardinals vs Chargers: 2025 season form
Los Angeles finished 11-6 at plus 28. Arizona went 3-14 at minus 133, closing on nine straight defeats.
| 2025 regular season | Cardinals | Chargers |
|---|---|---|
| Record | 3-14 | 11-6 |
| Points for | 355 | 368 |
| Points against | 488 | 340 |
| Point differential | -133 | +28 |
| Sacks recorded | 30 | 45 |
| Sacks allowed | 59 | 60 |
| Interceptions made | 10 | 19 |
| Third-down offence | 41.5% | 45.8% |
| Red-zone offence | 54.1% | 47.4% |
| Red zone allowed | 63.2% | 46.9% |
| Opponent passer rating | 97.6 | 75.0 |
The defensive rows separate them. Los Angeles held opponents to a 75.0 passer rating and made 19 interceptions, both the better marks. However the Chargers also allowed 60 sacks.
Cardinals vs Chargers injury report and team news
This section updates as soon as the Out, Doubtful and Questionable tags land. Notably, for now, one quarterback room is settled and the other is not.
The Cardinals have not confirmed a starter. Jacoby Brissett threw for 3,366 yards in 2025, though Gardner Minshew II and the rookie Carson Beck are both on the roster. Trey McBride leads the receivers regardless.
Justin Herbert starts for Los Angeles. Ladd McConkey and Quentin Johnston lead the receivers, meanwhile, with Omarion Hampton carrying the run game and David Njoku at tight end.
The matchup that settles it: the Chargers secondary against an unsettled Arizona passing game
Los Angeles conceded a 75.0 opponent passer rating in 2025 and intercepted 19 passes. Both figures lead this round.
Arizona threw for 3,955 yards, more than the Chargers managed. However they allowed 59 sacks doing it, and the quarterback remains undecided. Trey McBride is the counterweight, indeed, after 1,239 receiving yards.
Players to watch
- Justin Herbert (LAC, QB): 3,727 passing yards and 26 touchdowns, notably his most productive year.
- Tuli Tuipulotu (LAC, OLB): 13 sacks, indeed against a line that allowed 59.
- Trey McBride (ARI, TE): 1,239 receiving yards, sixth in the league and first among tight ends.
- James Conner (ARI, RB): Leads a backfield that gained 1,583 yards at 4.33 a carry.
How to watch Cardinals vs Chargers
Kickoff is 4:25 PM ET on Sunday, September 13, or 9.25pm BST in the UK. Sky Sports has the coverage, meanwhile, and NFL Game Pass on DAZN carries every game. The late Sunday window is the other genuinely watchable slot from Britain.
| Detail | Cardinals vs Chargers |
|---|---|
| Date | Sunday, September 13, 2026 |
| Kickoff | 9:25pm BST / 4:25 PM ET, Sunday 13 Sep |
| Venue | SoFi Stadium, Inglewood |
| TV | Sky Sports |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 1, 2026 NFL season |
Cardinals vs Chargers prediction and score projection
Our Cardinals vs Chargers prediction is a comfortable Los Angeles win. The best pass defence in the round against an offence with no confirmed quarterback is a straightforward read.
The Cardinals are not without weapons, with McBride and Michael Wilson both past 1,000 receiving yards. Nevertheless 59 sacks allowed tells you how it usually ended. So we will take the Chargers, 27-17. Which side carries the value, though, is a separate question from who wins, and the live read on that sits in the Signal block.
Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub. Kickoff times are confirmed on NFL.com.
Cardinals vs Chargers FAQ
Los Angeles, clearly. The Chargers finished 11-6 and allowed a 75.0 opponent passer rating, the best mark in the round, while Arizona went 3-14. Ultimately the live win probability sits in the Signal block on this page.
Notably 9.25pm BST on Sunday 13 September, which is 4:25 PM ET.
Sky Sports has the coverage and NFL Game Pass on DAZN carries every game. Moreover kickoff is Notably 9.25pm BST on Sunday 13 September, which is 4:25 PM ET.
Arizona had not confirmed a starter at the time of writing. Jacoby Brissett threw for 3,366 yards in 2025, and Gardner Minshew II and the rookie Carson Beck are also on the roster.
Chargers 27-17. Los Angeles held opponents to a 75.0 passer rating, and Arizona allowed 59 sacks while losing their final nine.
18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change