Our Colts vs Chiefs prediction is the pick of the overnight card for anyone staying up. Squawka Signal’s live read updates on this page through the week.
The Kansas City Chiefs beat Denver 31-10 on Monday night with 38 carries and a rushing performance of 173 yards from Kenneth Walker. The Indianapolis Colts lost 41-23 to Baltimore having conceded 202 on the ground themselves.
Colts vs Chiefs: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 18+ | BeGambleAware.org
Colts vs Chiefs: 2026 form so far
A 21-point win against an 18-point defeat, both of them decided on the ground.
| 2026 season to date | Colts | Chiefs |
|---|---|---|
| Record | 0-1 | 1-0 |
| Points for | 23 | 31 |
| Points against | 41 | 10 |
| Point differential | -18 | +21 |
| Total yards | 251 | 392 |
| Yards per play | 4.7 | 5.9 |
| Turnovers | 2 | 1 |
| Third-down offence | 30.0% | 52.9% |
| Red-zone offence | 100.0% | 60.0% |
| Sacks recorded | 2 | 4 |
| Opponent passer rating | 124.2 | 69.2 |
Kansas City converted 52.9% of third downs and recorded four sacks. Indianapolis converted every red-zone trip and still lost by 18.
Colts vs Chiefs injury report and team news
Kenneth Walker carried 23 times for 173 yards against Denver, the highest rushing total of the opening week. Patrick Mahomes threw for 184 at an 86.0 rating.
This section updates as soon as the Out, Doubtful and Questionable tags land.
The matchup that settles it: two running games and a defence that has already broken once
Kansas City ran 38 times on Monday and did not need Mahomes to be excellent. Indianapolis have already conceded four rushing touchdowns in a single afternoon.
Jonathan Taylor is the Colts’ route back into it. He averaged 5.2 a carry against Baltimore and scored twice, which is more than Denver managed all night.
Kansas City’s defence recorded four sacks and an interception in the opener. Daniel Jones is a more mobile problem than Bo Nix proved to be.
Players to watch
- Jonathan Taylor (IND, RB): 19 carries for 98 yards and two touchdowns against Baltimore.
- Daniel Jones (IND, QB): 166 yards and a touchdown in the opener, with one interception.
- Kenneth Walker (KC, RB): 173 rushing yards at 7.5 a carry against Denver.
- Patrick Mahomes (KC, QB): Two touchdown passes on Monday night, from 27 attempts.
How to watch Colts vs Chiefs
Kickoff is 1.20am BST in the early hours of Monday, September 21, which is 8:20 PM ET on the Sunday evening in Kansas City. Sky Sports has the UK coverage and NFL Game Pass on DAZN carries it live. Night games are never subject to the UK blackout, so it is on the live Game Pass feed. Squawka may earn a commission if you subscribe through that link.
| Detail | Colts vs Chiefs |
|---|---|
| Date | Sunday, September 20, 2026 |
| Kickoff | 1.20am BST Monday / 8:20 PM ET Sunday |
| Venue | Arrowhead Stadium, Kansas City, MO |
| TV | Sky Sports |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Colts vs Chiefs prediction and score projection
Our Colts vs Chiefs prediction is a Kansas City win, 30-20. Arrowhead on a Sunday night against a defence that cannot stop the run is a hard place to visit.
The live win probability updates on this page through the week.
Every fixture in the round is covered across our NFL UK hub, and the 32 club pages sit on the NFL teams hub.
Colts vs Chiefs FAQ
Kansas City, at home and clearly. The Chiefs won by 21 on Monday night while Indianapolis lost by 18.
1.20am BST in the early hours of Monday, September 21, which is 8:20 PM ET on the Sunday.
Sky Sports has the coverage and NFL Game Pass on DAZN streams it live.
Indianapolis lost 41-23 to Baltimore. Kansas City beat Denver 31-10.
18+ | Please gamble responsibly | BeGambleAware.org | Signal probabilities approximate at time of writing and subject to change