The Premier League returns for Gameweek 6 with fixtures taking place over Saturday and Sunday.
Newcastle against Arsenal takes centre stage on Sunday, with Aston Villa also hosting Fulham. On Saturday, the Brentford vs Man Utd kicks off proceedings at 12:30pm, while leaders Liverpool travel to Crystal Palace in a 3:00pm kick-off.
Here are the fixtures for Gameweek 6 (September 27–29, 2025), along with our predictions for each game.
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Brentford vs Man Utd – Saturday 27 September, 12:30pm
Manchester United got the better of Chelsea last weekend, but a close contest is expected here. Both teams have both shown defensive vulnerabilities this season, yet each side has consistently looked dangerous going forward. That combination suggests this weekend’s clash could deliver plenty of action and a narrow Man Utd victory looks likely with Bryan Mbeumo coming back to sting his former employers.
Prediction: Brentford 1-2 Man Utd (10/1 with Lottoland)
Leeds vs Bournemouth – Saturday 27 September, 3:00pm
Bournemouth start in fourth position following a blistering start to their Premier League campaign. They’ve won three of their opening five games and haven’t tasted defeat in their last four games, beating the likes of Tottenham and Brighton. Leeds haven’t started the season too badly, winning two of their opening five games, but Fulham and Arsenal have beaten them. Scoring goals has been the issue for Leeds, averaging less than a goal a game.
Prediction: Leeds 0-2 Bournemouth (8/1 with Lottoland)
Chelsea vs Brighton – Saturday 27 September, 3:00pm
Chelsea head into this clash averaging two goals per match and controlling the ball with 62% possession, a combination that makes them strong favourites. Defensively, they’ve allowed roughly one goal per game but have managed two clean sheets in five outings. Brighton, by contrast, are still searching for their first shutout of the season, having shipped eight goals in five matches and recorded only a single win during that stretch.
Prediction: Chelsea 2-0 Brighton (7/1 with Lottoland)
Man City vs Burnley – Saturday 27 September, 3:00pm
City have won 15 of the last 16 vs Burnley. Eight of the previous nine have seen City win without the Clarets getting on the scoresheet. Over the last nine matches, there has been an aggregate score of 31-1 in City’s favour.
Prediction: Man City 4-0 Burnley (12/1 with Lottoland)
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Crystal Palace vs Liverpool – Saturday 27 September, 3:00pm
Liverpool’s strong record against Crystal Palace speaks for itself — 12 wins from their last 17 meetings underline their superiority in this fixture. The Reds have made a flawless start to the league campaign too, winning all five matches while netting 11 times, though their defence has still been breached once per game on average. Palace, meanwhile, have enjoyed a solid opening, unbeaten in their first five outings and sitting fifth in the table, albeit with three draws and just six goals scored so far.
Prediction: Crystal Palace 1-3 (14/1 with Lottoland)
Nottingham Forest vs Sunderland – Saturday 27 September, 5:30pm
Sunderland’s return to the top flight has begun impressively, with the newly promoted side sitting seventh after two wins, two draws, and just one defeat. Resilient in their approach, they look capable of troubling a Forest side still adjusting under a new manager. Adding to Forest’s challenge, their midweek trip to Real Betis leaves them with less preparation time ahead of this weekend’s encounter.
Prediction: Nottingham Forest 0-1 Sunderland (11/1 with Lottoland)
Tottenham vs Wolves – Saturday 27 September, 8:00pm
Tottenham boast an impressive record against bottom-placed sides, unbeaten in their last 15 league meetings (12 wins, 3 draws). Wolves, meanwhile, remain pointless this season and continue to struggle. Since Thomas Frank took charge, Spurs have collected 10 points from five matches (W3 D1 L1) — already twice the tally they managed across their final 12 outings under Ange Postecoglou.
Prediction: Tottenham 3-0 Wolves (9/1 with Lottoland)
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Aston Villa vs Fulham – Sunday 28 September, 2:00pm
Villa managed a win against Bologna on Wednesday and after such a dry spell in the league, we should expect an upturn in goals in the coming weeks. Fulham can get on the score sheet and cause the hosts problems, and this scoreline fits Villa’s struggles and Fulham’s solid start; a realistic low-scoring draw.
Prediction: Aston Villa 1-1 Fulham (11/2 with Lottoland)
Newcastle vs Arsenal – Sunday 28 September, 4:30pm
Arsenal have scored more than 3x Newcastle’s tally and won 11 of last 19 H2Hs. The Gunners have started the season well and sit second in the league after picking up three wins in their first five Premier League games, beating Man Utd, Leeds and Nottingham Forest without conceding a goal. It’s not been quite as kind to Newcastle, who have drawn three of their opening five games, with their sole win being over lowly Wolves.
Prediction Newcastle 1-2 Arsenal (8/1 with Lottoland)
Everton vs West Ham – Monday 29 September, 8:00pm
Everton are yet to concede a Premier League goal at their new Hill Dickinson Stadium, beating Brighton 2-0 and drawing 0-0 with Aston Villa. Only Swansea (Liberty Stadium) and Spurs (Tottenham Hotspur Stadium) have kept a clean sheet in each of their first three Premier League games at a home venue. West Ham have been underwhelming this term and have lost on four of their five outings.
Prediction: Everton 2-0 West Ham