Our Cardinals vs 49ers prediction follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal’s live read on this game, including where the value sits, updates on this page through the week.
The San Francisco 49ers have conceded no sacks in two games, converted 63.2% of their third downs and scored on 87.5% of their red-zone trips. The Arizona Cardinals managed 151 total yards at home against Seattle. This is a difficult week to visit Levi’s Stadium.
Arizona Cardinals @ San Francisco 49ers
Arizona CardinalsSquawka21%Market22%▬ Fair
San Francisco 49ersSquawka79%Market78%▬ FairSquawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.
Cardinals vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT Our props
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Cardinals vs 49ers: 2026 form so far
One side is converting nearly everything and the other is converting almost nothing. The table sets each attack against what the other defense has allowed.
Cardinals attack against the 49ers defense
| Per game | Cardinals offense | 49ers allow |
|---|---|---|
| Passing yards | 179.0 | 175.0 |
| Rushing yards | 93.0 | 112.0 |
| Yards per carry | 3.6 | 3.9 |
| Passer rating | 86.2 | 80.9 |
| Touchdowns | 1.5 | 1.0 |
| Third-down conversion | 34.6% | 37.5% |
| Red-zone conversion | 50.0% | 20.0% |
| Sacks conceded / recorded | 1.5 | 2.0 |
49ers attack against the Cardinals defense
| Per game | 49ers offense | Cardinals allow |
|---|---|---|
| Passing yards | 246.0 | 203.0 |
| Rushing yards | 134.5 | 121.5 |
| Yards per carry | 4.7 | 4.0 |
| Passer rating | 125.6 | 110.9 |
| Touchdowns | 4.0 | 3.0 |
| Third-down conversion | 63.2% | 38.1% |
| Red-zone conversion | 87.5% | 62.5% |
| Sacks conceded / recorded | 0.0 | 2.0 |
Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.
San Francisco have not conceded a sack all season and are scoring on seven of eight red-zone trips. Arizona have taken 14 penalties for 159 yards, which does not help an offense already short of yards.
Cardinals vs 49ers injury report and team news
Brock Purdy completed 20 of 22 for 287 yards and two touchdowns against Miami at a 149.1 rating, and San Francisco scored on all five red-zone trips.
Jacoby Brissett completed 17 of 28 for 95 yards against Seattle as Arizona held the ball for 23:27.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Arizona CardinalsSan Francisco 49ersWhere Cardinals vs 49ers is decided
San Francisco’s protection is the number that stands out. No sacks conceded in two games, which is why Purdy has completed 45 of 56 and thrown five touchdowns.
Arizona’s problem is everything in front of the quarterback. One hundred and fifty-one yards against Seattle, 3.2 a play, and 23 and a half minutes of possession.
Consequently Trey McBride is the one route back. He caught eight for 41 and a touchdown in Week 2, and San Francisco have conceded only one touchdown pass.
Players to watch
- Trey McBride (ARI, TE): Eight catches and a touchdown against Seattle.
- Jacoby Brissett (ARI, QB): 95 passing yards in Week 2, from 28 attempts.
- Brock Purdy (SF, QB): 287 yards and two touchdowns at a 149.1 rating against Miami.
- George Kittle (SF, TE): Four catches for 80 yards and a score in Week 2.
How to watch Cardinals vs 49ers
Kickoff is 4:05 PM ET on Sunday, September 27 at Levi’s Stadium, which is 3:05 PM CT and 1:05 PM PT. FOX has the regional broadcast.
| Detail | Cardinals vs 49ers |
|---|---|
| Date | Sunday, September 27, 2026 |
| Kickoff | 4:05 PM ET / 3:05 PM CT / 1:05 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | FOX |
| Live stream | NFL+ / Fox One |
| Week | Week 3, 2026 NFL season |
Cardinals vs 49ers prediction and score projection
Our Cardinals vs 49ers prediction is a San Francisco win, 30-13. The 49ers are efficient in every phase and Arizona could not move the ball at home last week.
The live win probability and the model’s projected margin update on this page through the week.
Every Week 3 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Falcons @ Packers | Packers 23-10 | Read |
| Sun 1:00 PM | Panthers @ Browns | Panthers 24-20 | Read |
| Sun 1:00 PM | Bengals @ Steelers | Bengals 20-13 | Read |
| Sun 1:00 PM | Texans @ Colts | Colts 26-20 | Read |
| Sun 1:00 PM | Chiefs @ Dolphins | Chiefs 31-17 | Read |
| Sun 1:00 PM | Chargers @ Bills | Bills 31-20 | Read |
| Sun 1:00 PM | Patriots @ Jaguars | Patriots 20-16 | Read |
| Sun 1:00 PM | Jets @ Lions | Lions 27-20 | Read |
| Sun 1:00 PM | Seahawks @ Commanders | Seahawks 27-17 | Read |
| Sun 1:00 PM | Titans @ Giants | Titans 20-17 | Read |
| Sun 4:05 PM | Cardinals @ 49ers | 49ers 30-13 | You are here |
| Sun 4:05 PM | Vikings @ Buccaneers | Vikings 20-17 | Read |
| Sun 4:25 PM | Ravens @ Cowboys | Ravens 30-24 | Read |
| Sun 4:25 PM | Raiders @ Saints | Raiders 24-20 | Read |
| Sun 8:20 PM | Rams @ Broncos | Rams 26-17 | Read |
| Mon 8:15 PM | Eagles @ Bears | Eagles 24-20 | Read |
Every fixture in the round is covered across our NFL hub, and Signal rates every game on the NFL picks page.
Cardinals vs 49ers FAQ
San Francisco, at home and heavily. The 49ers are 2-0 with eight touchdowns; Arizona are 1-1 and gained 151 yards last week.
4:05 PM ET on Sunday, September 27, at Levi’s Stadium.
None in two games, against the Rams and Miami, which is a large part of why Brock Purdy is completing 80% of his throws.
Arizona lost 31-7 at home to Seattle. San Francisco beat Miami 35-13.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change