Columbus Crew vs Inter Miami: Predictions, Picks, Odds & Lineups

Columbus Crew host Inter Miami at ScottsMiracle-Gro Field on Sunday, September 27 (7:00 PM ET / 6:00 PM CT / 4:00 PM PT).

With no fresh fitness concerns flagged for either squad, both sides should be able to pick from close to full strength. Brais Méndez has driven Columbus’ recent form with 3 goals and 12 chances created in 652 minutes, while Taha Habroune has created a team-high 36 chances across 1707 minutes in midfield. For Inter Miami, Lionel Messi remains the headline act with 20 goals and 61 chances created in 2000 minutes, flanked by Luis Suárez’s 13 goals and Rodrigo De Paul’s 49 chances created from midfield.

Expect goals at both ends. Columbus have enough in Méndez and Habroune to trouble Inter Miami’s defense, but a group built around Messi’s 20 goals and Suárez’s 13 carries more than enough quality to see off a Crew side sitting 13th in the East on 26 points. Inter Miami, third on 46 points and firmly in the playoff picture, look the side better placed to make the extra goal count.

US viewers can watch Columbus Crew vs Inter Miami on Apple TV’s MLS Season Pass.

Season Form & Standings

Inter Miami sit third in the East on 46 points, firmly in the playoff picture, while Columbus Crew are 13th on 26 points, outside the current playoff picture with the regular season drawing to a close.

Eastern Conference

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Potential Match-Winners

• Brais Méndez (Columbus Crew): 3 goals and 12 chances created in 652 minutes make him Columbus’ most productive attacker this season.
• Lionel Messi (Inter Miami): 20 goals from 146 shots, with 60 on target, underline why he remains the most dangerous forward on the field.
• Luis Suárez (Inter Miami): 13 goals and 26 shots on target give Miami a second reliable source of goals alongside Messi.

Recent Form

Columbus Crew: L W L L W

• 2026-09-20: CF Montreal 0-2 Columbus Crew (W, away)
• 2026-09-13: Columbus Crew 0-1 New York Red Bulls (L, home)
• 2026-09-10: DC United 2-1 Columbus Crew (L, away)
• 2026-09-06: Columbus Crew 3-0 Colorado Rapids (W, home)
• 2026-08-30: Columbus Crew 1-3 New England Revolution (L, home)

Columbus’ form has bounced between extremes: a 3-0 home win over Colorado Rapids sat alongside home defeats to New England Revolution and New York Red Bulls, and an away loss at DC United, before a 2-0 win at CF Montreal snapped back into form last time out.

Inter Miami: W D D D D

• 2026-09-21: Inter Miami 2-2 San Diego FC (D, home)
• 2026-09-13: Inter Miami 2-2 Nashville SC (D, home)
• 2026-09-10: Chicago Fire 1-1 Inter Miami (D, away)
• 2026-09-06: Inter Miami 2-2 Atlanta United (D, home)
• 2026-08-30: Inter Miami 7-1 CF Montreal (W, home)

Inter Miami have drawn their last four matches. That includes 2-2 draws against Atlanta United and Nashville SC, a 1-1 at Chicago Fire, and a 2-2 at home to San Diego FC most recently. Those results followed a 7-1 rout of CF Montreal at the end of August.

Columbus Crew vs Inter Miami Prediction

Signal’s model lands on a 1-2 win for Inter Miami, with goals at both ends fitting a side that leans on Messi and Suárez to find a way through a stubborn opponent. Columbus, 13th in the East on 26 points, should have enough going forward through Méndez to get on the scoresheet, but third-placed Miami’s 46 points and firepower up top should be enough to see it home on the road.