Atletico San Luis vs Santos Laguna: Predictions, Picks, Odds & Lineups

Atletico San Luis host Santos Laguna at Estadio Alfonso Lastras Ramirez on Sunday, October 11 (7:00 PM ET / 6:00 PM CT / 4:00 PM PT).

No fresh absences are flagged for either side ahead of kickoff. Atletico San Luis should again lean on the attacking-midfield pair of David Rodriguez Uribe and Rafael Nicolas Llorente Sanz, who have scored three goals apiece this season, with defender Eduardo Aguila Castro also a threat from set pieces after a goal of his own. Santos Laguna travel with striker Ezequiel Eduardo Bullaude leading their attack on three goals, backed by midfielder Francisco Jose Villalba Rodrigo as the chief creator.

Atletico San Luis’s recent results have swung between big wins and defensive breakdowns — 3-2 at Pumas UNAM, 3-1 over Necaxa and 3-1 at Monterrey, against losses to Club Leon and Chivas — a pattern that points to goals at both ends rather than a shutout. Santos Laguna arrive off wins over Pachuca, Toluca and FC Juarez, with Bullaude heavily involved in that output, though a one-goal margin has been the trend rather than a flood of goals. Expect the hosts’ attacking midfield to find a way through in front of their own fans, with the visitors good enough to get one back.

US viewers can watch Atletico San Luis vs Santos Laguna on ViX, TUDN or Fox.

Season Form & Standings

League position isn’t part of the numbers we have on this one, so the formbook does the talking: Atletico San Luis’s last five league matches have read W L L W W, while Santos Laguna’s read D L W W W, and both sets of results arrive without fresh injury news to complicate selection.

Liga MX

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Potential Match-Winners

• David Rodriguez Uribe (Atletico San Luis): Three goals from twenty shots, with ten on target and eight chances created for others, make him Atletico San Luis’s most complete attacking outlet this season.
• Rafael Nicolas Llorente Sanz (Atletico San Luis): Also on three goals, Llorente Sanz has created eleven chances from twenty-four shots, giving the hosts a second reliable source of end product in midfield.
• Ezequiel Eduardo Bullaude (Santos Laguna): Bullaude leads Santos Laguna’s attack with three goals and fourteen shots on target from thirty-three attempts, making him the visitors’ most dangerous individual threat.

Recent Form

Atletico San Luis: W L L W W

• 2026-09-27: Pumas UNAM 2-3 Atletico San Luis (W, away)
• 2026-09-19: Atletico San Luis 3-1 Necaxa (W, home)
• 2026-09-14: Club Leon 2-0 Atletico San Luis (L, away)
• 2026-09-05: Atletico San Luis 0-3 Chivas (L, home)
• 2026-08-30: Monterrey 1-3 Atletico San Luis (W, away)

Atletico San Luis’s five most recent league results: a 3-2 win at Pumas UNAM, a 3-1 home win over Necaxa, a 2-0 loss at Club Leon, a 0-3 home loss to Chivas, and a 3-1 win at Monterrey.

Santos Laguna: D L W W W

• 2026-09-26: Santos Laguna 1-0 Pachuca (W, home)
• 2026-09-20: Toluca 2-3 Santos Laguna (W, away)
• 2026-09-13: Santos Laguna 2-1 FC Juarez (W, home)
• 2026-09-06: Cruz Azul 1-0 Santos Laguna (L, away)
• 2026-08-29: Santos Laguna 0-0 Tigres UANL (D, home)

Santos Laguna’s five most recent league results: a 1-0 home win over Pachuca, a 3-2 away win at Toluca, a 2-1 home win over FC Juarez, a 1-0 loss at Cruz Azul, and a 0-0 home draw with Tigres UANL.

Atletico San Luis vs Santos Laguna Prediction

This looks set to be a tight game with goals at both ends, but Atletico San Luis’s attacking midfield gives them the edge at home. Expect Rodriguez Uribe or Llorente Sanz to get on the scoresheet, Santos Laguna to find a response through Bullaude, and the hosts to edge it 2-1.