This week Squawka Signal calls 15 MLS fixtures. Its most confident pick is Inter Miami 2-1 DC United — Inter Miami to win at 68%. Through 187 graded picks this season, Signal is running at 44% on MLS results.
Squawka’s MLS predictions cover every fixture in the league — a projected scoreline and a win probability for each match, built by our data model, Squawka Signal.
This is new for the 2026 season. The card below runs through the next seven days of MLS action. For each game you get the most likely scoreline, the team the model favors, its win probability, and a direct link to trade or bet the call. And it refreshes every matchday, so each prediction sharpens as kickoff nears.
So how does it work? Signal is a team-strength model. It rates every MLS club’s attack and defense from two full seasons of results, it leans on recent form, and it factors in home advantage. It then turns those ratings into the single most likely scoreline for each game. The model draws on the same data that drives Squawka’s match previews. It is also fully transparent, and the AI Predictor methodology spells out exactly how it works.
MLS is one of the most competitive leagues in world soccer, and our MLS predictions reflect that. When the ratings back a clear favorite, Signal says so. When a match is genuinely even, it tells you that too. We then grade every pick against the real result, out in the open, so the record has to earn its number rather than simply claim one. For the fullest read on a game, pair the prediction with our MLS match previews, where you will also find team news and probable lineups.
MLS Predictions: AI Score Picks For Every Match
Updated 7 Oct 2026, 19:00 ET · next seven days of fixtures
Recent results
How to read it: the pick is Signal’s single most likely scoreline; the % is the model’s estimated chance the favored team wins the match — not the chance of that exact scoreline.
Matchday · Oct 10–11 ET
Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO/KY/MD/OH/PA/TN/VA/VT/WV) or (888) 789-7777 or visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), (800)-327-5050 or gamblinghelplinema.org (MA), or visit 1800gambler.net (WV). Odds approximate at time of writing.
How to read Squawka’s MLS predictions
Each row gives you three things: the scoreline Signal thinks is most likely, the side it favors, and how confident it is. A pick at 60% or higher is a firm lean. Anything near 40% is close to a coin toss, and we would rather tell you that than dress it up. So use the win probability, not just the scoreline, to judge how strong a call really is.
These MLS predictions update every matchday through the 2026 season, so check back during the week as fresh games move into the seven-day window. And for the biggest fixtures, read the MLS predictions here alongside the full match preview before you back anything.
More from the AI Predictor
- How the AI Predictor works — the full methodology, and how we measure it
- MLS on Squawka US — previews, stats, and analysis across the league
Latest MLS news
Match previews, player stats, and analysis from across the league are on the MLS desk.