Inter Miami vs Columbus Crew: Predictions, Picks, Odds & Lineups

Inter Miami host Columbus Crew at Nu Stadium on Saturday, November 21 (6:00 PM ET / 5:00 PM CT / 3:00 PM PT).

There’s no fresh team news to complicate selection at Nu Stadium, with both squads arriving unaffected by injury or suspension. Inter Miami’s attack remains built around Lionel Messi, who has scored 26 goals in 2664 minutes this season, flanked by Luis Suárez (17 goals) and Germán Berterame (10 goals), while Rodrigo De Paul supplies from midfield with 57 chances created. Columbus Crew will lean on Brais Méndez, who has 6 goals and 25 chances created in 1012 minutes, alongside Taha Habroune and Gonzalo Tapia, both among their more productive attackers this season.

Inter Miami sit second in the Eastern Conference on 60 points from 34 games, firmly in the playoff picture, while Columbus Crew sit seventh on 47 points, needing results to keep pace. Miami’s +21 goal difference underlines a team that scores goals and concedes them too, and Columbus have matched that trend on the road, winning 4-3 at Chicago Fire and 2-0 at FC Dallas during their current run. Both teams should find the net at Nu Stadium, but with Messi leading the line, Miami look good value to edge a tight one 2-1.

US viewers can watch Inter Miami vs Columbus Crew on Apple TV’s MLS Season Pass.

Season Form & Standings

Inter Miami sit second in the Eastern Conference with 60 points from 34 games (W16 D12 L6, GD +21), firmly in the playoff picture, while Columbus Crew are seventh on 47 points (W14 D5 L15, GD +7), still well placed but needing to close the gap.

Eastern Conference

Shop the matchInter Miami v Columbus CrewOfficial kits via Fanatics

adidasInter Miami CF adidas Authentic Home Jersey 2025 Messi #10$117.56ShopadidasColumbus Crew adidas Away Jersey 2025$76.87ShopadidasInter Miami CF adidas Away Shirt 2026 – Messi #10$59.50Shop

Squawka may earn a commission when you buy through these links, at no extra cost to you. Prices are set by the retailer and correct at time of publishing.

Potential Match-Winners

• Lionel Messi (Inter Miami): 26 goals and 74 chances created in 2664 minutes — the most dangerous forward on the field by some distance.
• Luis Suárez (Inter Miami): 17 goals from 57 shots, with 33 on target — a dangerous outlet alongside Messi up top.
• Brais Méndez (Columbus Crew): 6 goals and 25 chances created in 1012 minutes, the player most likely to trouble Miami on the counter.

Recent Form

Inter Miami: W L D W D

• 2026-11-07: Inter Miami 3-3 Charlotte FC (D, home)
• 2026-11-02: New England Revolution 1-2 Inter Miami (W, away)
• 2026-10-28: Inter Miami 2-2 FC Cincinnati (D, home)
• 2026-10-24: New York Red Bulls 2-0 Inter Miami (L, away)
• 2026-10-18: Atlanta United 1-3 Inter Miami (W, away)

Inter Miami have gone W L D W D across their last 5 games: a 3-1 win at Atlanta United, a 2-0 defeat at New York Red Bulls, a 2-2 draw with FC Cincinnati, a 2-1 win at New England Revolution and a 3-3 draw with Charlotte FC most recently.

Columbus Crew: W W W W W

• 2026-11-07: Chicago Fire 3-4 Columbus Crew (W, away)
• 2026-10-31: Columbus Crew 3-0 DC United (W, home)
• 2026-10-29: FC Dallas 0-2 Columbus Crew (W, away)
• 2026-10-24: Columbus Crew 4-2 Toronto FC (W, home)
• 2026-10-18: FC Cincinnati 0-2 Columbus Crew (W, away)

Columbus Crew have won all 5 of their last 5: a 2-0 win at FC Cincinnati, 4-2 at home to Toronto FC, 2-0 at FC Dallas, 3-0 at home to DC United and 4-3 at Chicago Fire most recently.

Inter Miami vs Columbus Crew Prediction

With Messi in red-hot scoring form and Miami’s attack carrying a +21 goal difference, this looks set to finish 2-1 in the hosts’ favor at Nu Stadium. Columbus Crew’s 5-game winning streak keeps them in the Eastern Conference playoff conversation at seventh on 47 points, but a second-place side with 60 points and this much firepower should have too much quality in the final third. Expect goals at both ends, with Miami’s class proving decisive.