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Inter Miami vs Columbus Crew: Predictions, Picks, Odds & Lineups

Inter Miami vs Columbus Crew predicted formations

Inter Miami host Columbus Crew at Nu Stadium on Saturday, November 21 (6:00 PM ET / 5:00 PM CT / 3:00 PM PT).

No fresh absences have been flagged for either side heading into this one, with Inter Miami able to call on their full attacking cast. Lionel Messi leads the line on 26 goals this season, with Luis Suárez (17 goals) and Germán Berterame (10 goals) both expected to feature alongside him, while Rodrigo De Paul adds 6 goals and 57 chances created from midfield, rounding out Miami’s most dangerous unit. Columbus Crew travel with their own scoring options fit and available: Brais Méndez and Gonzalo Tapia have each struck 6 goals, Taha Habroune has added 5 with 52 chances created, and Anass Zaroury (3 goals) and Mohamed Farsi (2 goals, 25 chances created) offer further threat from midfield.

Inter Miami sit second in the Eastern Conference with 60 points from 34 games and a +21 goal difference, the platform of a side still pushing for a high playoff seed. Columbus Crew, seventh with 47 points and a +7 mark, arrive full of confidence after a run of 5 straight wins, but Miami’s firepower and conference standing make them favourites to edge a tight, cagey contest here at home.

Inter Miami vs Columbus Crew: Best Bets & Predictions

Messi and Miami look to tighten their grip on a playoff spot against an in-form Columbus side.

Inter MiamiTop pickMiami sit second in the East with 60 points from 34 games and a +21 goal difference, well clear of Columbus's 47 points and +7 mark in seventh.
Inter Miami 2-1 Columbus CrewMessi's 26 goals give Miami the edge up front, but Méndez and Tapia (6 goals apiece) keep Columbus capable of a reply.
YesMiami's attack runs through Messi, Suárez and Berterame (26, 17 and 10 goals respectively), while Columbus have Méndez, Tapia and Habroune among their own scorers.
Over 2.5Between Messi's 183 shots this season and Columbus's Habroune creating 52 chances, both sides have the attacking output to push this past 2.5 goals.
Lionel Messi to score anytime26 goals from 2664 minutes, with 75 shots on target, makes him the standout scoring threat on the pitch.
⭐⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we weigh the underlying numbers over the table alone, and while Columbus carry value as the outsiders, Miami's conference standing and squad depth still point to a narrow home win.

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Season Form & Standings

Inter Miami sit second in the Eastern Conference with 60 points from 34 games, firmly in the playoff picture, while Columbus Crew are seventh with 47 points, still needing results to hold their place in the post-season picture.

Eastern Conference

TeamPosGPWDLGFGAGDPts
Inter Miami234161268059+2160
Columbus Crew734145155952+747
Team News Predicted

Inter Miami vs Columbus Crew Predicted Lineups

Predicted XI — updated for the latest team news.

Inter Miami

4-3-3
D. St. Clair
Sergio Reguilon
Micael
Casemiro
I. Fray
T. Segovia
D. Ayala
R. De Paul
G. Berterame
L. Suarez
L. Messi

Columbus Crew

3-4-3
P. Schulte
M. Amundsen
S. Zawadzki
Steven Moreira
A. Zaroury
S. Bangoura
D. Chambost
M. Farsi
S. Rodriguez
G. Tapia
T. Habroune
    Squawka · Team News

    Potential Match-Winners

    • Lionel Messi (Inter Miami): 26 goals, 183 shots and 75 on target from 2664 minutes — still the most reliable finisher on either team sheet.
    • Rodrigo De Paul (Inter Miami): six goals and 57 chances created from midfield, De Paul is the supply line behind Miami’s front two.
    • Taha Habroune (Columbus Crew): 5 goals and 52 chances created in 2373 minutes make him Columbus’s most productive attacking outlet.

    Recent Form

    Inter Miami: W L D W D

    • 2026-11-07: Inter Miami 3-3 Charlotte FC (D, home)
    • 2026-11-02: New England Revolution 1-2 Inter Miami (W, away)
    • 2026-10-28: Inter Miami 2-2 FC Cincinnati (D, home)
    • 2026-10-24: New York Red Bulls 2-0 Inter Miami (L, away)
    • 2026-10-18: Atlanta United 1-3 Inter Miami (W, away)

    Miami’s form reads W L D W D: a 3-1 win at Atlanta United, a 2-0 loss at New York Red Bulls, a 2-2 draw with FC Cincinnati, a 2-1 win at New England Revolution, and, most recently, a 3-3 draw at home to Charlotte FC.

    Columbus Crew: W W W W W

    • 2026-11-07: Chicago Fire 3-4 Columbus Crew (W, away)
    • 2026-10-31: Columbus Crew 3-0 DC United (W, home)
    • 2026-10-29: FC Dallas 0-2 Columbus Crew (W, away)
    • 2026-10-24: Columbus Crew 4-2 Toronto FC (W, home)
    • 2026-10-18: FC Cincinnati 0-2 Columbus Crew (W, away)

    Columbus arrive on a run of 5 straight wins: a 2-0 win at FC Cincinnati, a 4-2 win over Toronto FC, a 2-0 win at FC Dallas, a 3-0 win over DC United, and, most recently, a 4-3 win away at Chicago Fire.

    Inter Miami vs Columbus Crew Prediction

    We’re backing Inter Miami to see this out 2-1. Sitting second in the East with 60 points, they have too much quality in Messi and Suárez for a Columbus side that, despite sitting seventh with 47 points, has scoring threats of their own in Méndez and Tapia. Expect goals at both ends, but Miami’s class should tell in a tight finish.