Inter Milan host Shakhtar Donetsk at Stadio Giuseppe Meazza on Wednesday, October 21 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).
There’s no fresh team news to flag on the fitness front for either side here, with no injury or suspension concerns on the sheet. Inter Milan should still have Lautaro Martínez leading the line, already up to 2 goals and 6 shots on target through 180 minutes, with Federico Dimarco (6 chances created) and Andy Diouf (5 chances created) supplying from midfield, while defender Carlos Augusto adds a threat at set pieces after netting once himself. Shakhtar Donetsk can call on Gleiker Mendoza, who has 2 goals from just 4 shots in the opening weeks, with Isaque’s 2 assists showing he can unlock a defence from deeper positions.
Inter arrive off the back of back-to-back defeats, a 3-4 home loss to Club Brugge and a 2-1 defeat away at Real Madrid, while Shakhtar’s only form line on record is a tidy 1-1 draw at PSV. That contrast points to a cagey night at San Siro: Inter will be looking to tighten up after conceding freely last time out, and with neither side settled into a rhythm of easy goals, this has the hallmarks of a tight, low-scoring contest rather than an open shootout.
Inter Milan vs Shakhtar Donetsk: Best Bets & Predictions
Lautaro Martínez and Inter Milan look to snap a 2-match losing run against an unbeaten Shakhtar Donetsk side at San Siro.
Our approach: we blend underlying shot and chance data with current form and matchup context to land on one clear, stat-backed selection in each market.
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Season Form & Standings
Inter Milan’s league position isn’t settled in the data here, but the form line is clear: 2 straight defeats heading in. Shakhtar Donetsk, by contrast, are unbeaten through 2 matches, with 1 win and 1 draw for 4 points and a +2 goal difference.
Champions League
| Team | Pos | GP | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| Shakhtar Donetsk | 11 | 2 | 1 | 1 | 0 | 4 | 2 | +2 | 4 |
Inter Milan vs Shakhtar Donetsk Predicted Lineups
Predicted XI — updated for the latest team news.
Inter Milan
3-5-2Shakhtar Donetsk
4-1-4-1Potential Match-Winners
- Lautaro Martínez (Inter Milan): 2 goals from 16 shots, 6 of them on target, through 180 minutes make him Inter’s most complete attacking threat.
- Federico Dimarco (Inter Milan): 6 chances created and an assist from his wide role show he’s still Inter’s main creative outlet.
- Gleiker Mendoza (Shakhtar Donetsk): 2 goals from just 4 shots in 93 minutes make him Shakhtar’s most direct route to goal.
Recent Form
Inter Milan: L L
- 2026-10-13: Inter Milan 3-4 Club Brugge (L, home)
- 2026-09-08: Real Madrid 2-1 Inter Milan (L, away)
Inter Milan have lost their last 2, going down 3-4 at home to Club Brugge before a 2-1 defeat away at Real Madrid.
Shakhtar Donetsk: D
- 2026-09-10: PSV 1-1 Shakhtar Donetsk (D, away)
Shakhtar Donetsk’s most recent result was a 1-1 draw away at PSV.
Inter Milan vs Shakhtar Donetsk Prediction
This has the look of a tight, low-scoring night at San Siro. Lautaro Martínez’s movement and end product – 2 goals and 6 shots on target already this season – should be enough to prise open a well-organized Shakhtar defence just once, and with Inter sharpening up after their recent defensive wobbles, that lone goal should be enough. Prediction: Inter Milan 1-0 Shakhtar Donetsk.