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Como vs Manchester United: Predictions, Picks, Odds & Lineups

Como vs Manchester United predicted formations

Como host Manchester United at Stadio Giuseppe Sinigaglia on Wednesday, October 21 (12:45 PM ET / 11:45 AM CT / 9:45 AM PT).

Como go into this with no fresh fitness concerns reported, and the lineup picture centres on the players who have carried their start to the season. Anastasios Douvikas and Assane Diao Diaoune have each scored two goals in Como’s opening matches, while Martin Baturina has added a goal and four chances created from the attacking midfield. For Manchester United, Bruno Fernandes leads the creative numbers with five chances created, and both Matheus Cunha and Benjamin Šeško have already scored in their minutes on the pitch.

Both sides have shown they can score goals in bursts and concede them just as easily. Como’s midfield pairing of Baturina and Diao Diaoune offers end product alongside Douvikas up front, while United lean on Fernandes and Cunha to create and finish chances of their own. Expect goals at both ends, with the hosts’ extra firepower in behind proving the difference.

Como vs Manchester United: Best Bets & Predictions

Como's home scoring form meets Manchester United's away reconstruction job in this Champions League clash.

Como to winTop pickComo match Manchester United's points and goal difference tally but did it with a 4-1 home win over RB Leipzig, a result that outweighs United's 4-0 win over Sabah in style if not in table impact.
43%win prob.opening soon @ bet365
Como 2-1 Manchester UnitedDouvikas and Diao Diaoune have each scored 2 goals already this season, and with Fernandes, Cunha and Šeško all on the scoresheet for United, a 2-1 finish matches the goalscoring form on show.
⭐⭐⭐⭐⭐chanceopening soon @ bet365
Both Teams to Score – YesComo put 4 past RB Leipzig and United put 4 past Sabah in their respective wins, so firepower isn't the issue for either side here.
60%chanceopening soon @ bet365
Over 2.5 GoalsThose same matches produced 5 and 4 goals respectively, and with Douvikas, Diao Diaoune, Fernandes and Cunha all among the goals already, goals at both ends look likely.
58%chanceopening soon @ bet365
Anastasios Douvikas to score anytimeDouvikas has 2 goals from 3 shots, with 2 of them on target, in just 95 minutes – a genuine goal threat up front for the hosts.
⭐⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we weigh each side's actual stats this season – goals, shots on target and chances created – rather than reputation, to land on our Result, Correct Score, BTTS and Over/Under picks.

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Season Form & Standings

Como and Manchester United go into this level on the clock, both with three points from two matches played and matching plus-two goal differences after one win and one loss apiece.

Champions League

TeamPosGPWDLGFGAGDPts
Como12210164+23
Manchester United13210142+23
Team News Predicted

Como vs Manchester United Predicted Lineups

Predicted XI — updated for the latest team news.

Como

4-2-3-1
Robert Sanchez
Alex Valle
T. Chalobah
Jacobo Ramon
I. Smolcic
M. Perrone
Luis Milla
Kaiki
M. Baturina
A. Diao
N. Paz

Manchester United

4-2-3-1
S. Lammens
A. Heaven
L. Martinez
L. Yoro
Diogo Dalot
C. Baleba
Andrey Santos
M. Rashford
Y. Tielemans
Bruno Fernandes
B. Mbeumo
    Squawka · Team News

    Potential Match-Winners

    • Anastasios Douvikas (Como): 2 goals from 3 shots, with 2 on target, in just 95 minutes of action so far.
    • Martin Baturina (Como): 1 goal and 4 chances created from 145 minutes, plus 1 assist, from the attacking midfield.
    • Bruno Fernandes (Manchester United): 1 goal, 6 shots and 5 chances created from 170 minutes played.

    Recent Form

    Como: W

    • 2026-09-10: Como 4-1 RB Leipzig (W, home)

    Como’s sole result on record is a 4-1 win over RB Leipzig on September 10.

    Manchester United: W L

    • 2026-10-13: Atletico Madrid 2-0 Manchester United (L, away)
    • 2026-09-10: Manchester United 4-0 Sabah (W, home)

    Manchester United’s most recent match was a 2-0 loss away to Atletico Madrid on October 13, following a 4-0 win at home to Sabah on September 10.

    Como vs Manchester United Prediction

    Como and Manchester United go into this with matching three-point returns and identical plus-two goal differences from their opening two matches, but the home surface and Como’s sharper finishing edge in behind should be enough to separate them. Expect goals from both the Douvikas-Diao Diaoune axis and from Fernandes at the other end, with Como’s extra threat in the final third landing the win. We’re backing a 2-1 Como victory.