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Atletico Madrid vs Manchester United: Predictions, Picks, Odds & Lineups

Atletico Madrid vs Manchester United predicted formations

Atletico Madrid host Manchester United at Estadio Wanda Metropolitano on Tuesday, October 13 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).

No fresh fitness concerns have surfaced for either side, and both arrive with clear pictures of who leads the way. Atletico Madrid’s threat starts with Julián Alvarez, who put three shots on target and claimed an assist in their opening match, alongside midfielder Marcos Llorente Moreno, who scored the only goal they managed. Pablo Barrios Rivas and Alejandro Baena Rodríguez add the creative support through the centre of the park. Manchester United will again lean on Bruno Fernandes and Matheus Cunha, who both scored in their opening win, with Benjamin Šeško and Bryan Mbeumo offering further options off the bench or from the start.

Atletico Madrid shipped two goals in their own defeat to Liverpool, a sign their defence can be got at, while Manchester United’s attack has already shown firepower with four goals in one outing. Both teams have scored in their opening matches, and with Alvarez and Llorente Moreno capable of adding to Atletico Madrid’s own tally, an open game looks the likely shape of this one — with the home side’s extra threat in behind just about expected to nose it in a 2-1 finish.

Atletico Madrid vs Manchester United: Best Bets & Predictions

Atletico Madrid aim to bounce back at home against a Manchester United side flush with confidence after their own opening-day rout.

Atletico Madrid to winTop pickJulián Alvarez already put three shots on target and claimed an assist in Atletico Madrid's opening match, underlining a home attack sharp enough to get the better of this one.
46%win prob.opening soon @ bet365
Correct ScoreMarcos Llorente Moreno has already scored for Atletico Madrid, and with Manchester United's Bruno Fernandes and Matheus Cunha both on the scoresheet in their own opening match, a tight 2-1 edge for the hosts fits the goals already on show from both sides.
Both Teams to Score – YesAtletico Madrid got on the scoresheet through Marcos Llorente Moreno despite conceding, while Manchester United had three separate scorers in their own opener, a pattern that points to goals at both ends again here.
Over 2.5 GoalsManchester United's 4-0 win and Atletico Madrid's 2-1 defeat both produced plenty of goals. With scorers already spread across both squads, the over looks well covered again.
Anytime GoalscorerMarcos Llorente Moreno scored from his only shot on target across 90 minutes against Liverpool, making him Atletico Madrid's likeliest source of goals in behind the front line.
⭐⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we weigh standings context, early-season form and underlying player data (shots, chances created, goals) to anchor the Result, Correct Score, BTTS and Over/Under picks before layering in the standout performers most likely to influence the scoreline.

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Season Form & Standings

Atletico Madrid have 0 points from 1 game, with a -1 goal difference after a 2-1 loss to Liverpool on the road. Manchester United have 3 points from 1 game, boosted by a +4 goal difference after thumping Sabah 4-0 at home.

Champions League

TeamPosGPWDLGFGAGDPts
Manchester United4110040+43
Atletico Madrid25100112-10
Team News Predicted

Atletico Madrid vs Manchester United Predicted Lineups

Predicted XI — updated for the latest team news.

Atletico Madrid

3-5-2
J. Oblak
D. Hancko
C. Romero
Marc Pubill
G. Simeone
Alex Baena
Koke
Pablo Barrios
Marcos Llorente
J. Alvarez
Lee Kang-In

Manchester United

4-2-3-1
S. Lammens
P. Dorgu
L. Martinez
L. Yoro
N. Mazraoui
K. Mainoo
Y. Tielemans
Matheus Cunha
Bruno Fernandes
B. Mbeumo
B. Sesko
    Squawka · Team News

    Potential Match-Winners

    • Marcos Llorente Moreno (Atletico Madrid): The midfielder scored Atletico Madrid’s goal against Liverpool, converting his only shot on target across 90 minutes on the pitch.
    • Julián Alvarez (Atletico Madrid): The striker fired three shots, all three on target, and added an assist in Atletico Madrid’s opening match, still waiting for his first goal of the campaign.
    • Bruno Fernandes (Manchester United): The attacking midfielder scored and created four chances from three shots in Manchester United’s opening win, directly involved at both ends of the pitch.

    Recent Form

    Atletico Madrid: L

    • 2026-09-09: Liverpool 2-1 Atletico Madrid (L, away)

    Atletico Madrid’s only outing so far ended in a 2-1 loss away to Liverpool.

    Manchester United: W

    • 2026-09-10: Manchester United 4-0 Sabah (W, home)

    Manchester United’s sole match so far was a 4-0 win over Sabah at home.

    Atletico Madrid vs Manchester United Prediction

    Atletico Madrid sit on 0 points after 1 game while Manchester United have 3 points from their own opener, but home advantage and a sharper look at Marcos Llorente Moreno and Julián Alvarez should be enough to get Atletico Madrid over the line. Expect goals at both ends again, with Manchester United’s attack good for another through Bruno Fernandes or Matheus Cunha, before Atletico Madrid’s extra edge settles it 2-1.