Home » News » MLS » Columbus Crew vs Inter Miami: Predictions, Picks, Odds & Lineups

Columbus Crew vs Inter Miami: Predictions, Picks, Odds & Lineups

Columbus Crew vs Inter Miami predicted formations

Columbus Crew host Inter Miami at ScottsMiracle-Gro Field on Sunday, September 27 (7:00 PM ET / 6:00 PM CT / 4:00 PM PT).

Columbus Crew go into this one with no fresh injury news to report, so the picture starts with the players already carrying the attack. Attacking midfielder Brais Méndez remains the one to watch in behind the front line, with three goals and 12 chances created this season, while midfielder Taha Habroune has been the busiest creator in the group, adding two goals and a team-high 36 chances created. Inter Miami are similarly clean on the fitness front, and striker Lionel Messi leads the way on 20 goals, 60 shots on target and 61 chances created, with fellow striker Luis Suárez offering a second scoring outlet on 13 goals from 45 shots.

Columbus Crew vs Inter Miami: Best Bets & Predictions

Playoff-chasing Inter Miami visit a Columbus side already outside the picture

Inter MiamiTop pickInter Miami sit third in the East on 46 points against Columbus's 13th-place total of 26, a gap in the table that lines up with Miami's far deeper attacking options.
Columbus Crew 1-2 Inter MiamiMiami have drawn 4 straight games rather than shutting teams out, which points to Columbus getting on the board too even as Miami's firepower edges it.
YesColumbus carry a -5 goal difference that shows a defence prone to conceding, while Miami have posted 2-2 scorelines in back-to-back matches this month.
Over 2.5
Lionel Messi to score anytimeMessi leads every player in this preview with 20 goals from 146 shots this season, making him the standout individual threat on the pitch.
⭐⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we anchor every pick to what the standings, recent results and underlying attacking numbers actually show, then let the model settle on a scoreline before pricing the markets around it.

Back these with bet365Odds shown in American format; your local odds may vary.
Bet with bet365 → bet365 review

Odds correct at time of writing and shown in American format for illustration; your local odds may vary. 19+ (18+ in AB/MB/QC). Please play responsibly. ConnexOntario: 1-866-531-2600 (ON).

Season Form & Standings

Columbus Crew sit 13th in the East on 26 points from 26 games (7 wins, 5 draws, 14 losses, -5 goal difference), well outside the playoff picture. Inter Miami are third in the East on 46 points from the same 26 games (12 wins, 10 draws, 4 losses, +15), firmly in the playoff picture.

Eastern Conference

TeamPosGPWDLGFGAGDPts
Inter Miami326121046348+1546
Columbus Crew132675143742-526
Team News Predicted

Columbus Crew vs Inter Miami Predicted Lineups

Predicted XI — updated for the latest team news.

Columbus Crew

3-4-2-1
P. Schulte
M. Amundsen
S. Zawadzki
Steven Moreira
A. Zaroury
Andre Gomes
T. Habroune
M. Farsi
S. Rodriguez
Brais Mendez
Josef Martinez

Inter Miami

4-3-3
D. St. Clair
F. Caicedo
M. Falcon
Casemiro
F. Mura
M. Galarza
Y. Bright
R. De Paul
G. Berterame
L. Suarez
L. Messi
    Squawka · Team News

    Potential Match-Winners

    • Brais Méndez (Columbus Crew): Columbus’s clearest creative source, with 3 goals and 12 chances created from his advanced midfield role this season.
    • Lionel Messi (Inter Miami): Leads every scorer in this preview with 20 goals from 146 shots, and remains capable of deciding a game on his own.
    • Luis Suárez (Inter Miami): 13 goals from 45 shots gives Miami a proven second scoring threat alongside Messi up top.

    Recent Form

    Columbus Crew: L W L L W

    • 2026-09-20: CF Montreal 0-2 Columbus Crew (W, away)
    • 2026-09-13: Columbus Crew 0-1 New York Red Bulls (L, home)
    • 2026-09-10: DC United 2-1 Columbus Crew (L, away)
    • 2026-09-06: Columbus Crew 3-0 Colorado Rapids (W, home)
    • 2026-08-30: Columbus Crew 1-3 New England Revolution (L, home)

    L W L L W across the last five: a 1-3 home loss to New England Revolution, a 3-0 home win over Colorado Rapids, a 2-1 loss at DC United, a 0-1 home loss to the New York Red Bulls, then a 2-0 win at CF Montreal most recently.

    Inter Miami: W D D D D

    • 2026-09-21: Inter Miami 2-2 San Diego FC (D, home)
    • 2026-09-13: Inter Miami 2-2 Nashville SC (D, home)
    • 2026-09-10: Chicago Fire 1-1 Inter Miami (D, away)
    • 2026-09-06: Inter Miami 2-2 Atlanta United (D, home)
    • 2026-08-30: Inter Miami 7-1 CF Montreal (W, home)

    W D D D D: a 7-1 win over CF Montreal, then draws of 2-2 with Atlanta United, 1-1 at Chicago Fire, 2-2 with Nashville SC and 2-2 with San Diego FC most recently.

    Columbus Crew vs Inter Miami Prediction

    Signal’s model has this finishing Columbus Crew 1-2 Inter Miami. Columbus, 13th in the East, have enough going forward through Méndez and Habroune to cause Miami’s defence some problems, but Inter Miami’s position third in the East, driven by the goals of Messi and Suárez, should be enough to get the win on the road.