Trade Markets
Trade $25, Get $25 Bonus
Trade Markets
Trade $25, Get $25 in Bonuses
Trade Markets
Deposit $10 Get $25 Trading Bonus
Trade Markets
Trade $50, Earn $75 in Trading Bonus
Trade Markets
Spend 5 get $50 in Novig Coins CODE:SQUAWKA
Trade Markets
Newcomer Bonus Up to $500
Home » News » Champions League » Inter Milan vs Shakhtar Donetsk: Predictions, Picks, Odds & Lineups

Inter Milan vs Shakhtar Donetsk: Predictions, Picks, Odds & Lineups

Inter Milan vs Shakhtar Donetsk predicted formations

Inter Milan host Shakhtar Donetsk at Stadio Giuseppe Meazza on Wednesday, October 21 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).

Inter Milan have no fitness worries to speak of and will again lean on Lautaro Martínez, who already has two goals and four chances created to his name this term, with Federico Dimarco offering a steady outlet from the left. Shakhtar Donetsk travel with their own spark in Gleiker Mendoza, who has scored twice in Europe this season, and the creative touch of Isaque Silva pulling the strings in midfield.

US viewers can watch Inter Milan vs Shakhtar Donetsk on Paramount+.

Squawka Signal
Match outcome · who wins
Inter MilanInter Milan55%mkt 80%Our pick
DrawDraw23%mkt 24%
Shakhtar DonetskShakhtar Donetsk22%mkt 30%

Inter Milan vs Shakhtar Donetsk: Best Bets & Predictions

The market prices Under 2.5 at 26%. Signal says 47%.

+21points of value · the goals market
Kalshi80¢
Back Inter Milan @ 80¢ · Kalshi · $100 → $125New to Kalshi? Trade $25, Get $25 Bonus · use code SQUAWKA · 18+

Best live price across US prediction markets · buy YES on Inter Milan

Back Inter Milan with bet365
The tips · best bets
MarketMkt %Signal %Read
Correct ScoreInter Milan 1-0 Shakhtar DonetskShakhtar's goalscorers so far have been a defender and a midfielder rather than a recognized striker, which points to a tight scoreline at San Siro.
—
13%
Model read
›
Both Teams to ScoreBoth teams: NoWith no out-and-out striker among Shakhtar's top scorers and Inter's own forward line producing little beyond Martínez, a clean sheet at one end looks more likely than goals at both.
45%
50%
Value
›
Over / Under 2.5Under 2.5Diouf and Dimarco have combined for 11 chances created but no goals between them this term, underlining how narrow Inter's cutting edge has been in front of goal.
26%
47%
Strong value
›
Anytime ScorerLautaro Martínez to score anytimeMartínez has 2 goals already this term, with 6 of his 16 shots finding the target — the clearest route to goal in this fixture.
—
—
Model read
Signal edge callsRecord building · settles at full-time

Compare all markets ›bet365 review ›

Available to US traders in all 50 states · 18+Odds from bet365 · 18+ · begambleaware.org

Season Form & Standings

Shakhtar Donetsk sit on four points from two games played, with a plus-two goal difference underlining an unbeaten start in continental action. Inter Milan, by contrast, head into this one on the back of back-to-back defeats, including a 3-4 home collapse against Club Brugge and a 2-1 loss away to Real Madrid.

Champions League

TeamPosGPWDLGFGAGDPts
Shakhtar Donetsk11211042+24
Shop the matchInter Milan v Shakhtar DonetskOfficial kits via Fanatics
Squawka may earn a commission when you buy through these links, at no extra cost to you. Prices are set by the retailer and correct at time of publishing.
Team News Predicted

Inter Milan vs Shakhtar Donetsk Predicted Lineups

Predicted XI — updated for the latest team news.

Inter Milan

3-5-2
Josep Martinez
A. Bastoni
M. Akanji
Y. Bisseck
F. Dimarco
P. Zielinski
H. Calhanoglu
N. Barella
A. Diouf
L. Martinez
M. Thuram

Shakhtar Donetsk

4-1-4-1
D. Riznyk
Pedro Henrique
M. Matviienko
V. Bondar
Vinicius Tobias
O. Ocheretko
Newerton
Marlon Gomes
Pedrinho
Alisson Santana
Kaua Elias
    Squawka · Team News

    Potential Match-Winners

    • Lautaro Martínez (Inter Milan): 2 goals and 4 chances created already this term, with 6 of his 16 shots on target, make Martínez Inter’s most direct route to goal.
    • Federico Dimarco (Inter Milan): Dimarco has created 6 chances from 3 shots in limited minutes, underlining his creative influence from the left.
    • Gleiker Mendoza (Shakhtar Donetsk): Mendoza leads Shakhtar’s scoring with 2 goals from 4 shots, giving them a genuine threat in behind the front line.

    Recent Form

    Inter Milan: L L

    • 2026-10-13: Inter Milan 3-4 Club Brugge (L, home)
    • 2026-09-08: Real Madrid 2-1 Inter Milan (L, away)

    Inter Milan’s last two have both ended in defeat: a 3-4 home shootout loss to Club Brugge, followed by a 2-1 reverse away at Real Madrid.

    Shakhtar Donetsk: D

    • 2026-09-10: PSV 1-1 Shakhtar Donetsk (D, away)

    Shakhtar Donetsk’s only result in the data is a 1-1 draw away at PSV, continuing their unbeaten start to the campaign.

    Inter Milan vs Shakhtar Donetsk Prediction

    This has the makings of a cagey night rather than an open one. Inter arrive having lost back-to-back games, so there’s little appetite at San Siro for another leaky evening, while Shakhtar remain unbeaten but short of a recognized out-and-out striker beyond Mendoza. Expect Martínez to find the breakthrough and Inter to see it out: 1-0 to Inter Milan.