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Rams vs Cardinals Prediction, Picks & Odds

Los Angeles Rams vs Arizona Cardinals prediction, picks and odds for Week 10 of the 2026 NFL season

Arizona won the Week 6 meeting 18-16 in Los Angeles and have lost five of six since. The Rams concede 31.6% on third down, fourth in the NFL. Our Rams vs Cardinals prediction is a rematch the record books say should not be close.

The Los Angeles Rams are 5-4 at +33. The Arizona Cardinals are 3-6 at -77, the second-worst differential in the league.

Week 10 · Editorial pick

Rams vs Cardinals: our editor’s props

Two editor’s calls on this game, alongside the live Signal numbers.

Rams AT Cardinals

Our props

Player propArizona under 2 touchdownsArizona score 1.9 touchdowns a game and convert 42.9% in the red zone, 30th. Los Angeles concede 1.8, which is fifth.
★★★★☆4/5 confidence
Player propMatthew Stafford 230+ passing yardsLos Angeles throw for 254 a game, seventh in the NFL, and Arizona concede a 108.9 opponent rating, 31st.
★★★☆☆3/5 confidence

An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.

Rams vs Cardinals: 2026 form so far

A 5-4 team at a 3-6 one, except the 3-6 team won the first meeting. The table sets each attack against what the opposite defense has actually allowed.

Rams attack against the Cardinals defense

Per gameRams offenseCardinals allow
Passing yards254.4215.4
Rushing yards125.3121.9
Yards per carry4.74.2
Passer rating90.5108.9
Touchdowns3.03.4
Third-down conversion40.0%40.7%
Red-zone conversion66.7%70.0%
Sacks conceded / recorded1.42.1

Cardinals attack against the Rams defense

Per gameCardinals offenseRams allow
Passing yards215.3198.7
Rushing yards102.7103.8
Yards per carry4.14.0
Passer rating84.082.3
Touchdowns1.91.8
Third-down conversion38.0%31.6%
Red-zone conversion42.9%43.3%
Sacks conceded / recorded2.61.8

Los Angeles concede 31.6% on third down and 43.3% in the red zone, fourth and sixth in the NFL.

Los Angeles Rams 5-4 · average margin +3.7

+10−10+20−20Week 1: lost to the 49ers 7-27 (home)vSF1Week 2: beat the Giants 28-6 (home)vNYG2Week 3: lost to the Broncos 26-30 (away)@DEN3Week 4: beat the Eagles 24-20 (away)@PHI4Week 5: lost to the Bills 34-37 (home)vBUF5Week 6: lost to the Cardinals 16-18 (home)vARI6Week 7: beat the Raiders 35-21 (away)@LV7Week 8: beat the Chargers 24-9 (home)vLAC8Week 9: beat the Commanders 20-13 (away)@WAS9

Arizona Cardinals 3-6 · average margin -8.6

+10−10+20−20Week 1: beat the Chargers 26-14 (away)@LAC1Week 2: lost to the Seahawks 7-31 (home)vSEA2Week 3: lost to the 49ers 30-36 (away)@SF3Week 4: lost to the Giants 24-36 (away)@NYG4Week 5: lost to the Lions 21-45 (home)vDET5Week 6: beat the Rams 18-16 (away)@LA6Week 7: lost to the Broncos 16-30 (home)vDEN7Week 8: beat the Cowboys 33-30 (away)@DAL8Week 9: lost to the Seahawks 3-17 (away)@SEA9
One bar per game this season, in week order. Bars above the line are wins and below are defeats, sized by margin. “v” is a home game and “@” an away game. Hover or tap a bar for the score. Bye weeks are left blank, so a gap in a run of form is visible rather than hidden.

Rams vs Cardinals quarterback matchup

Matthew Stafford completed 26 of 43 for 228 yards at 72.6 in a 20-13 win in Washington. Gardner Minshew II went 21 of 30 for 166 with no touchdowns at 83.5.

TeamQuarterbackLast gameSeason to date
RamsMatthew Stafford26/43, 228 yds, 1 TD, 1 INT, 72.6 rtg230/346, 2374 yds, 16 TD, 9 INT, 90.6 rtg (9 games)
CardinalsGardner Minshew II21/30, 166 yds, 0 TD, 0 INT, 83.5 rtg38/53, 354 yds, 3 TD, 0 INT, 108.5 rtg (2 games)
Last game is Week 9. Season figures are 2026 to date, with games played in brackets.

Rams vs Cardinals injury report and team news

Arizona won the Week 6 meeting 18-16 in Los Angeles.

Arizona concede a 108.9 opponent passer rating, 31st in the NFL.

Los Angeles concede 31.6% on third down, fourth in the league.

A defense that gets off the field against one that does not

Los Angeles have the better of almost every column. They score 3.0 touchdowns a game, convert 66.7% in the red zone and concede 1.8 touchdowns, which is fifth.

Arizona’s defense is the opposite: a 108.9 opponent rating is 31st in the NFL and 3.4 touchdowns conceded a game is 31st. Their own red zone converts 42.9%, which is 30th.

What complicates it is Week 6. Arizona won 18-16 in Los Angeles in a game where neither team reached 20, and the Rams have not been convincing in the throw game since — Stafford rated 72.6 last week.

Los Angeles RamsArizona Cardinals

Their own numbers

Touchdowns per gameLos Angeles Rams: 3.0, 10th of 32Arizona Cardinals: 1.9, 25th of 3210th3.01.925thPassing yards per gameLos Angeles Rams: 254, 7th of 32Arizona Cardinals: 215, 18th of 327th25421518thRushing yards per gameLos Angeles Rams: 125, 9th of 32Arizona Cardinals: 103, 22nd of 329th12510322ndYards per carryLos Angeles Rams: 4.66, 6th of 32Arizona Cardinals: 4.09, 19th of 326th4.664.0919thThird-down conversionLos Angeles Rams: 40.0%, 13th of 32Arizona Cardinals: 38.0%, 15th of 3213th40.0%38.0%15thRed-zone conversionLos Angeles Rams: 66.7%, 8th of 32Arizona Cardinals: 42.9%, 30th of 328th66.7%42.9%30thSacks per gameLos Angeles Rams: 1.8, 27th of 32Arizona Cardinals: 2.1, 18th of 3227th1.82.118thInterceptions per gameLos Angeles Rams: 0.8, 11th of 32Arizona Cardinals: 0.3, 28th of 3211th0.80.328th
Each club’s own production, per game this season. The small grey number is the league rank out of 32.

What opponents have managed against them

Touchdowns per gameLos Angeles Rams: 1.8, 5th of 32Arizona Cardinals: 3.4, 31st of 325th1.83.431stPassing yards per gameLos Angeles Rams: 199, 5th of 32Arizona Cardinals: 215, 13th of 325th19921513thRushing yards per gameLos Angeles Rams: 104, 14th of 32Arizona Cardinals: 122, 19th of 3214th10412219thYards per carryLos Angeles Rams: 3.96, 13th of 32Arizona Cardinals: 4.19, 20th of 3213th3.964.1920thThird-down conversionLos Angeles Rams: 31.6%, 4th of 32Arizona Cardinals: 40.7%, 20th of 324th31.6%40.7%20thRed-zone conversionLos Angeles Rams: 43.3%, 6th of 32Arizona Cardinals: 70.0%, 27th of 326th43.3%70.0%27thSacks per gameLos Angeles Rams: 1.4, 5th of 32Arizona Cardinals: 2.6, 20th of 325th1.42.620thInterceptions per gameLos Angeles Rams: 1.0, 26th of 32Arizona Cardinals: 0.8, 23rd of 3226th1.00.823rd
What each club’s opponents have managed, per game. Ranks here run the other way: first is the lowest number conceded, not the highest. The ringed dot is the better figure.

Players to watch

  • Matthew Stafford (LA, QB): Leads an offense scoring 3.0 touchdowns a game.
  • Konata Mumpfield (LA, WR): Led the Rams’ available receivers in the win in Washington.
  • Trey McBride (ARI, TE): A primary target in a passing game rating 84.0.
  • Michael Wilson (ARI, WR): Led Arizona’s receivers in the defeat in Seattle.

How Rams vs Cardinals last unfolded

Los Angeles Rams scored on 3 of 10 drives  ·  Arizona Cardinals scored on 6 of 10 drives

Q1LAQ1 Los Angeles Rams: +9 yards, 3 plays, Punt+9 yds, 3 playsPuntQ1ARIQ1 Arizona Cardinals: +5 yards, 3 plays, Interception+5 yds, 3 playsInterceptionQ1LAQ1 Los Angeles Rams: +6 yards, 6 plays, Field Goal, 3 points+6 yds, 6 playsField GoalQ1ARIQ1 Arizona Cardinals: +37 yards, 8 plays, Field Goal, 3 points+37 yds, 8 playsField GoalQ1LAQ1 Los Angeles Rams: +8 yards, 3 plays, Punt+8 yds, 3 playsPuntQ1ARIQ1 Arizona Cardinals: +68 yards, 10 plays, Field Goal, 3 points+68 yds, 10 playsField GoalQ2LAQ2 Los Angeles Rams: +68 yards, 12 plays, Touchdown, 6 points+68 yds, 12 playsTouchdownQ2ARIQ2 Arizona Cardinals: +6 yards, 3 plays, Punt+6 yds, 3 playsPuntQ2LAQ2 Los Angeles Rams: +4 yards, 3 plays, Punt+4 yds, 3 playsPuntQ2ARIQ2 Arizona Cardinals: +64 yards, 12 plays, Field Goal, 3 points+64 yds, 12 playsField GoalQ2LAQ2 Los Angeles Rams: +12 yards, 2 plays, End of Half+12 yds, 2 playsEnd of HalfQ3ARIQ3 Arizona Cardinals: +66 yards, 15 plays, Field Goal, 3 points+66 yds, 15 playsField GoalQ3LAQ3 Los Angeles Rams: +41 yards, 9 plays, Downs+41 yds, 9 playsDownsQ3ARIQ3 Arizona Cardinals: +63 yards, 14 plays, Field Goal, 3 points+63 yds, 14 playsField GoalQ4LAQ4 Los Angeles Rams: +14 yards, 4 plays, Fumble+14 yds, 4 playsFumbleQ4ARIQ4 Arizona Cardinals: +4 yards, 3 plays, Punt+4 yds, 3 playsPuntQ4LAQ4 Los Angeles Rams: +33 yards, 7 plays, Downs+33 yds, 7 playsDownsQ4ARIQ4 Arizona Cardinals: +0 yards, 3 plays, Punt+0 yds, 3 playsPuntQ4LAQ4 Los Angeles Rams: +91 yards, 8 plays, Touchdown, 7 points+91 yds, 8 playsTouchdownQ4ARIQ4 Arizona Cardinals: +25 yards, 5 plays, Field Goal, 3 points+25 yds, 5 playsField Goal
Every drive of the last meeting, in order. Bar length is net yards and a solid bar is a drive that ended in points.
0714Q1 9:41 · Los Angeles Rams Field Goal, 3 points · Rams 3 Cardinals 0Q1 5:37 · Arizona Cardinals Field Goal, 3 points · Rams 3 Cardinals 3Q1 14:51 · Arizona Cardinals Field Goal, 3 points · Rams 3 Cardinals 6Q2 8:23 · Los Angeles Rams Touchdown, 6 points · Rams 9 Cardinals 6Q2 00:46 · Arizona Cardinals Field Goal, 3 points · Rams 9 Cardinals 9Q3 6:25 · Arizona Cardinals Field Goal, 3 points · Rams 9 Cardinals 12Q3 9:28 · Arizona Cardinals Field Goal, 3 points · Rams 9 Cardinals 15Q4 00:47 · Los Angeles Rams Touchdown, 7 points · Rams 16 Cardinals 15Q4 00:00 · Arizona Cardinals Field Goal, 3 points · Rams 16 Cardinals 18
The score through that game, one step per scoring play. Built from the drive feed rather than typed in, which is checkable: the derived final reads Los Angeles Rams 16, Arizona Cardinals 18, and that is the real final score.

How to watch Rams vs Cardinals

Kickoff is 4:05 PM ET on Sunday, November 15 at State Farm Stadium, which is 3:05 PM CT and 1:05 PM PT. CBS has the broadcast.

DetailRams vs Cardinals
DateSunday, November 15, 2026
Kickoff4:05 PM ET / 3:05 PM CT / 1:05 PM PT
VenueState Farm Stadium, Glendale, AZ
TVCBS
Live streamNFL+ / Paramount+
WeekWeek 10, 2026 NFL season

Rams vs Cardinals prediction and score projection

Los Angeles win 24-16. Arizona have the head-to-head and nothing else, and a defense conceding 3.4 touchdowns a game will not hold a 5-4 team to 16 twice.

The live spread and our projected margin both update on this page through the week.

Every Week 10 game, previewed

Kickoff (ET)GameOur predictionPreview
Thu 8:15 PMCommanders @ GiantsGiants 23-20Read
Sun 9:30 AMPatriots @ LionsLions 31-24Read
Sun 1:00 PMBills @ JetsBills 30-17Read
Sun 1:00 PMPanthers @ SaintsSaints 27-24Read
Sun 1:00 PMTexans @ BrownsTexans 26-17Read
Sun 1:00 PMJaguars @ TitansJaguars 27-13Read
Sun 1:00 PMChiefs @ FalconsChiefs 27-16Read
Sun 1:00 PMDolphins @ ColtsColts 20-16Read
Sun 1:00 PMVikings @ PackersPackers 20-13Read
Sun 4:05 PMRams @ CardinalsRams 24-16You are here
Sun 4:05 PMSeahawks @ RaidersSeahawks 27-13Read
Sun 4:25 PM49ers @ Cowboys49ers 34-24Read
Sun 8:20 PMSteelers @ BengalsBengals 27-23Read
Mon 8:15 PMChargers @ RavensRavens 23-13Read

The rest of the round sits in our pick record and our wider NFL analysis. The outright markets are priced in Super Bowl LXI odds. We price the player markets in NFL player props.

Rams vs Cardinals FAQ

Who is favored, the Rams or the Cardinals?

Los Angeles. The Rams are 5-4 at +33 and Arizona 3-6 at -77. The live number sits in the Signal card on this page.

Who won the last Rams vs Cardinals game?

Arizona, 18-16 in Week 6, and they won it in Los Angeles.

What time is Rams vs Cardinals?

4:05 PM ET on Sunday, November 15 at State Farm Stadium, which is 3:05 PM CT and 1:05 PM PT.

Why are Arizona at -77?

The defense. They concede 3.4 touchdowns a game and a 108.9 opponent passer rating, both 31st in the NFL.

21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change