Santos Laguna vs Pumas UNAM: Predictions, Picks, Odds & Lineups

Santos Laguna host Pumas UNAM at Estadio Corona on Wednesday, October 21 (11:10 PM ET / 10:10 PM CT / 8:10 PM PT).

Santos Laguna have no fresh team-news concerns to factor in here, which should keep Ezequiel Bullaude at the heart of things — the midfielder has produced 3 goals, 2 assists and 18 created chances from 933 minutes this season, with Francisco Villalba offering another outlet after creating 27 chances of his own. Pumas UNAM travel with a similarly settled group: Olavio Vieira dos Santos Junior arrives as the division’s standout finisher with 6 goals in 731 minutes, Robert Morales has chipped in 3 goals and 3 assists from his 885 minutes, and defender Rodrigo Lopez Quinones adds an extra outlet at set pieces after scoring once and creating 14 chances from the back.

Both sides have been loose at the back this season — Santos Laguna sit on a -4 goal difference, Pumas UNAM on -2 — and recent results have followed suit, including a 3-2 shootout for the hosts at Toluca and a 3-3 draw for the visitors against Cruz Azul. Expect a similarly open contest in La Laguna, where Santos Laguna’s sharper attacking numbers and the momentum of 4 straight wins should just about see them home 2-1.

US viewers can watch Santos Laguna vs Pumas UNAM on ViX, TUDN or Fox.

Season Form & Standings

Santos Laguna and Pumas UNAM are locked together on 13 points from 11 games apiece in the Apertura, both still fighting for position in the Liguilla picture, though Pumas UNAM’s -2 goal difference is tidier than the -4 posted by the hosts.

Liga MX

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Potential Match-Winners

• Ezequiel Bullaude (Santos Laguna): The midfielder has been Santos Laguna’s creative engine this season, contributing 3 goals, 2 assists and 18 created chances from 933 minutes.
• Francisco Villalba (Santos Laguna): Villalba’s 27 created chances lead the Santos Laguna squad, and he’s added 2 goals and 2 assists of his own across 752 minutes.
• Olavio Vieira dos Santos Junior (Pumas UNAM): Olavio leads the way for Pumas UNAM with 6 goals in 731 minutes, backed by 16 shots and 8 on target.

Recent Form

Santos Laguna: L W W W W

• 2026-10-11: Atletico San Luis 1-2 Santos Laguna (W, away)
• 2026-09-26: Santos Laguna 1-0 Pachuca (W, home)
• 2026-09-20: Toluca 2-3 Santos Laguna (W, away)
• 2026-09-13: Santos Laguna 2-1 FC Juarez (W, home)
• 2026-09-06: Cruz Azul 1-0 Santos Laguna (L, away)

Santos Laguna: L W W W W — 4 straight wins following the opening-day loss at Cruz Azul, most recently a 2-1 comeback win away at Atletico San Luis.

Pumas UNAM: W L D L D

• 2026-10-11: Pumas UNAM 3-3 Cruz Azul (D, home)
• 2026-09-27: Pumas UNAM 2-3 Atletico San Luis (L, home)
• 2026-09-19: Atlas FC 1-1 Pumas UNAM (D, away)
• 2026-09-13: Chivas 3-0 Pumas UNAM (L, away)
• 2026-09-10: Pumas UNAM 3-1 Club Leon (W, home)

Pumas UNAM: W L D L D — a 3-3 home draw with Cruz Azul last time out, having also lost to Atletico San Luis and Chivas and drawn with Atlas FC earlier in that run.

Santos Laguna vs Pumas UNAM Prediction

Santos Laguna and Pumas UNAM go into this level on 13 points from 11 games, both still scrapping for a spot inside the Liguilla picture, but Santos Laguna’s recent form gives them the edge. The hosts have won 4 straight since that opening defeat at Cruz Azul, with Bullaude (3 goals, 2 assists) and Villalba (2 goals, 27 created chances) driving things forward, while Pumas UNAM’s -2 goal difference and shakier away form open the door at the other end. Expect goals in both boxes before Santos Laguna see it through, 2-1.