Our Dolphins vs 49ers prediction is the most one-sided call of the late window. Squawka Signal’s live read on this game, including where the value sits, updates on this page through the week.
The San Francisco 49ers beat the Rams 27-7 in Melbourne with three passing touchdowns. The Miami Dolphins lost 27-13 at Las Vegas, where Malik Willis was sacked five times. Consequently the gap between these two is as wide as any on the card.
Miami Dolphins @ San Francisco 49ers
Miami DolphinsSquawka22%Market12%▲ Strong value
San Francisco 49ersSquawka78%Market88%▼ OverpricedSquawka Signal is our model’s read against devigged market prices, updated after every result — not betting advice. How the NFL Signal works. 21+. Play responsibly. Full T&Cs & geo-restrictions apply: Kalshi, Polymarket, ProphetX.
Dolphins vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT Our props
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Dolphins vs 49ers: 2026 form so far
A 1-0 team that won by 20 against a 0-1 team that could not protect its quarterback. The table is not subtle.
| 2026 season to date | Dolphins | 49ers |
|---|---|---|
| Record | 0-1 | 1-0 |
| Points for | 13 | 27 |
| Points against | 27 | 7 |
| Point differential | -14 | +20 |
| Total yards | 259 | 379 |
| Yards per play | 5.2 | 5.9 |
| Turnovers | 2 | 1 |
| Third-down offense | 20.0% | 58.3% |
| Red-zone offense | 33.3% | 66.7% |
| Sacks recorded | 0 | 0 |
| Opponent passer rating | 88.2 | 62.8 |
San Francisco converted 58.3% of third downs and held the ball for almost 34 minutes. Miami managed 20% and 25 minutes, and were sacked five times.
Dolphins vs 49ers injury report and team news
Malik Willis completed 15 of 27 for Miami at a 66.9 rating and was sacked five times. De’Von Achane carried 11 times for 36 yards.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Miami DolphinsSan Francisco 49ersWhere Dolphins vs 49ers is decided
Miami’s protection is the immediate problem. Five sacks conceded at Las Vegas, against a San Francisco front that did not need one to win by 20.
Brock Purdy threw three touchdowns from 34 attempts and Christian McCaffrey averaged 6.8 a carry. San Francisco did not have to force anything.
Miami’s defense did force two interceptions at Las Vegas, so there is a route to staying in it. Nevertheless they conceded three touchdown passes in the same game.
Players to watch
- Malik Willis (MIA, QB): 220 yards, no touchdowns and five sacks taken at Las Vegas.
- De’Von Achane (MIA, RB): 11 carries for 36 yards in the opener.
- Brock Purdy (SF, QB): Three touchdown passes at a 105.6 rating against the Rams.
- Christian McCaffrey (SF, RB): Ten carries for 68 yards at 6.8 a carry.
How to watch Dolphins vs 49ers
The game kicks off at 4:25 PM ET on Sunday, September 20 at Levi’s Stadium in Santa Clara. FOX carries it. It sits in the later Sunday afternoon window.
| Detail | Dolphins vs 49ers |
|---|---|
| Date | Sunday, September 20, 2026 |
| Kickoff | 4:25 PM ET / 3:25 PM CT / 1:25 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | FOX |
| Live stream | NFL Game Pass (DAZN) |
| Week | Week 2, 2026 NFL season |
Dolphins vs 49ers prediction and score projection
Our Dolphins vs 49ers prediction is a San Francisco win, 30-13. The 49ers are better in every phase, and Miami cannot keep their quarterback upright.
For the model’s read rather than ours, the live number updates on this page.
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 2 game the same way.
Dolphins vs 49ers FAQ
San Francisco, clearly. The 49ers won their opener 27-7; Miami lost 27-13 and conceded five sacks.
4:25 PM ET on Sunday, September 20, which is 3:25 PM CT and 1:25 PM PT.
FOX has the game in the United States.
San Francisco beat the Rams 27-7 in Melbourne. Miami lost 27-13 at Las Vegas.
21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change