Toluca vs Santos Laguna: Predictions, Picks, Odds & Lineups

Toluca host Santos Laguna at Estadio Nemesio Diez on Sunday, September 20 (8:00 PM ET / 7:00 PM CT / 5:00 PM PT).

Toluca have no fresh fitness concerns to speak of ahead of hosting Santos Laguna at Estadio Nemesio Diez, with Federico Vinas leading the line after three goals from eighteen shots this season. Ernesto Vega and Jesus Angulo are expected to run midfield, Vega arriving with two goals and twelve chances created and Angulo adding fifteen chances created and an assist, while Jesus Gallardo and Everardo Lopez del Villar offer an extra outlet from set pieces after each has scored once this term. For Santos Laguna, Ezequiel Bullaude remains the focal point up front, with two goals and seven shots on target from twenty-three attempts overall, while Francisco Villalba and Mauricio Cuevas dictate tempo in midfield — Cuevas has created sixteen chances and Villalba fifteen, though neither has scored yet this season.

Toluca head into this one off a 5-2 win over Atlas FC and a run of 5 wins, 1 draw and 1 loss from seven league matches this season, good for 16 points and a +11 goal difference. Santos Laguna, meanwhile, have won none of their last 5 in league play (L L L D L), including a 3-2 loss at Puebla and a goalless draw with Tigres UANL, form that points to a side searching for rhythm on the road. With Vinas the clearest attacking threat on the pitch and Bullaude Santos’ only real out ball, this sets up as a game Toluca should control without needing to force it — tight and low-scoring rather than an end-to-end shootout.

US viewers can watch Toluca vs Santos Laguna on ViX, TUDN or Fox.

Season Form & Standings

Toluca have collected 16 points from 7 league matches this season — 5 wins, 1 draw and 1 loss — with a +11 goal difference underlining how dominant that run has been. Santos Laguna, meanwhile, have won none of their last five in league play (L L L D L), a stretch that has left them well off that pace.

Liga MX

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Potential Match-Winners

• Federico Vinas (Toluca): The striker leads Toluca with 3 goals from 18 shots and 5 on target in 276 minutes, and he’s the most direct route to goal in this Toluca side.
• Ernesto Vega (Toluca): The midfielder has 2 goals and 12 chances created in 398 minutes, giving Toluca a threat from both midfield and in behind.
• Ezequiel Bullaude (Santos Laguna): The striker has 2 goals from 23 shots, 7 on target and 13 chances created in 687 minutes — comfortably Santos Laguna’s most involved attacker even amid the team’s poor run.

Recent Form

Toluca: W D W W W

• 2026-09-13: Toluca 5-2 Atlas FC (W, home)
• 2026-08-30: Toluca 4-0 FC Juarez (W, home)
• 2026-08-21: Queretaro FC 1-2 Toluca (W, away)
• 2026-08-15: Atlante FC 0-0 Toluca (D, away)
• 2026-08-02: Toluca 3-1 Necaxa (W, home)

Toluca: W D W W W — 5 wins, a draw and just 1 loss across their last 7, capped by a 5-2 win over Atlas FC.

Santos Laguna: L L L D L

• 2026-09-06: Cruz Azul 1-0 Santos Laguna (L, away)
• 2026-08-29: Santos Laguna 0-0 Tigres UANL (D, home)
• 2026-08-22: Club Puebla 3-2 Santos Laguna (L, away)
• 2026-08-16: Santos Laguna 0-1 Chivas (L, home)
• 2026-08-02: Club America 3-0 Santos Laguna (L, away)

Santos Laguna: L L L D L — no wins in their last 5, including a 1-0 loss at Cruz Azul and a goalless draw with Tigres UANL.

Toluca vs Santos Laguna Prediction

The Signal model lands on a 2-0 win for Toluca, a controlled, low-scoring afternoon that fits both sides’ recent form — Toluca have lost just once in 7 league matches this season, while Santos Laguna arrive winless in their last 5. Expect Vinas to make the difference at one end and a Santos Laguna side short on confidence to be kept at arm’s length at the other.