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Home » News » Champions League » Real Madrid vs RB Leipzig: Predictions, Picks, Odds & Lineups

Real Madrid vs RB Leipzig: Predictions, Picks, Odds & Lineups

Real Madrid vs RB Leipzig predicted formations

Real Madrid host RB Leipzig at Estadio Santiago Bernabéu on Wednesday, October 21 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).

Real Madrid have no fresh absentees to contend with here, and Kylian Mbappé looks set to lead the line again after a flying start that has brought him 2 goals from 8 shots, all 8 on target, in his first 2 Champions League appearances this season. Federico Valverde and Antonio Rüdiger have also scored 1 goal each, while Arda Güler has created 3 chances and supplied 2 assists in just 31 minutes off the bench. RB Leipzig arrive with Brajan Gruda and Andrija Maksimović both among the goals already this season, and Antonio Nusa’s 7 shots in 2 matches signal an attack that is creating chances even without the end product.

This shapes up as a tighter watch than the raw talent on show might suggest. Leipzig have shown they can go toe-to-toe going forward, with Nusa’s 7 shots and Gruda’s 4 created chances pointing to real intent, but their defense has looked open on the road. Madrid, by contrast, look well drilled at both ends, and with Mbappé in this kind of shape, control of the game rather than an avalanche of goals feels like the likelier route to victory. A composed, low-event night finishing 2-0 to the hosts fits the pattern better than an end-to-end shootout.

US viewers can watch Real Madrid vs RB Leipzig on Paramount+.

Squawka Signal
Match outcome · who wins
Real MadridReal Madrid78%mkt 77%Our pick
DrawDraw13%mkt 12%
RB LeipzigRB Leipzig9%mkt 11%

Real Madrid vs RB Leipzig: Best Bets & Predictions

The market prices Both teams: No at 38%. Signal says 42%.

+4points of value · both teams to score
Kalshi76¢
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Best live price across US prediction markets · buy YES on Real Madrid

Back Real Madrid with bet365
The tips · best bets
MarketMkt %Signal %Read
Correct ScoreReal Madrid 2-0 RB LeipzigWith Mbappé firing at a 2-goals-from-eight-shots clip and Leipzig toiling to score on the road, a clean 2-0 scoreline for the hosts fits the shape of this one.
—
9%
Model read
›
Both Teams to ScoreBoth teams: NoLeipzig shipped 4 goals in their last away match at Como, and Madrid's control at the Bernabéu should limit the visitors to half chances, backing No for Both Teams to Score.
38%
42%
Value
›
Over / Under 2.5Under 2.5A disciplined Madrid performance built around control rather than haste points to a total under 2.5 goals, in line with the 2-0 scoreline our model projects.
22%
25%
Value
›
Anytime ScorerKylian Mbappé to score anytimeMbappé has scored in each of Madrid's opening 2 matches, totaling 2 goals from 8 shots, making him the likeliest source of goals here.
—
93%
Model read
Signal edge callsRecord building · settles at full-time

Compare all markets ›bet365 review ›

Available to US traders in all 50 states · 18+Odds from bet365 · 18+ · begambleaware.org

Season Form & Standings

Real Madrid have won 2 from 2 this season, good for 6 points and a +2 goal difference. RB Leipzig have taken 3 points from 2 games, winning 1 and losing 1, with a -2 goal difference.

Champions League

TeamPosGPWDLGFGAGDPts
Real Madrid8220064+26
RB Leipzig21210124-23
Shop the matchReal Madrid v RB LeipzigOfficial kits via Fanatics
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Team News Predicted

Real Madrid vs RB Leipzig Predicted Lineups

Predicted XI — updated for the latest team news.

Real Madrid

4-2-3-1
T. Courtois
Marc Cucurella
A. Rudiger
I. Konate
D. Dumfries
A. Tchouameni
F. Valverde
Vinicius Junior
J. Bellingham
Y. Diomande
K. Mbappe

RB Leipzig

4-2-3-1
M. Vandevoordt
D. Raum
C. Lukeba
W. Orban
R. Baku
E. Banzuzi
N. El Aynaoui
A. Nusa
C. Nkunku
B. Gruda
Romulo
    Squawka · Team News

    Potential Match-Winners

    • Kylian Mbappé (Real Madrid): Mbappé has 2 goals from 8 shots, all 8 on target, in his first 2 Champions League appearances this term.
    • Federico Valverde (Real Madrid): The defensive midfielder has scored 1 goal in 180 minutes and adds 3 shots of his own, a reminder of Madrid’s goal threat from deep.
    • Brajan Gruda (RB Leipzig): Gruda has 1 goal and four chances created from just 96 minutes so far, with three of his four shots on target, an early sign of the creative spark Leipzig need to stay in this one.

    Recent Form

    Real Madrid: W

    • 2026-09-08: Real Madrid 2-1 Inter Milan (W, home)

    Real Madrid’s only featured result this season is a 2-1 home win over Inter Milan on September 8.

    RB Leipzig: L W

    • 2026-10-13: RB Leipzig 1-0 PSV (W, home)
    • 2026-09-10: Como 4-1 RB Leipzig (L, away)

    RB Leipzig beat PSV 1-0 at home on October 13, after losing 4-1 away at Como on September 10.

    Real Madrid vs RB Leipzig Prediction

    Real Madrid’s 6 points from 2 games and +2 goal difference head into this one as considerable favorites over a RB Leipzig side on three points from two games with a -two difference. Expect Madrid’s control and Mbappé’s sharpness in front of goal to be the difference, with Leipzig’s defensive gaps on the road enough to be undone once but not twice. Real Madrid 2-0 RB Leipzig.