Liverpool vs Atletico Madrid: Predictions, Picks, Odds & Stats

Liverpool host Atletico Madrid at Anfield on Wednesday, September 9 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).

Liverpool head into this Champions League fixture at Anfield without injured Joseph Gomez, back-problem sufferer Federico Chiesa, cruciate-ligament casualty Giovanni Leoni, calf-injury absentee Hugo Ekitike, and knee-issue absentee Conor Bradley, a run of unavailability that puts extra weight on Dominik Szoboszlai, Alexis Mac Allister, Virgil van Dijk, Cody Gakpo, and Florian Wirtz to carry Liverpool’s attack. Atletico Madrid have a gap of their own with injured Obed Vargas missing, but travel with Julián Alvarez, Marcos Llorente, Giuliano Simeone, and Dávid Hancko all available and central to how they’ll look to trouble the hosts.

There’s a clear contrast in how these two teams create danger. Liverpool’s threat is spread through midfield as much as the front line, with Szoboszlai and Wirtz between them producing a level of chance creation that few sides in Europe can match, while Atletico Madrid lean heavily on Alvarez’s finishing to turn moments into goals. Anfield under the lights is an obvious lift for the hosts, but Atletico Madrid’s mix of experienced operators, from Llorente’s energy to Hancko’s composure at the back, means this won’t be a straightforward night for Liverpool.

US viewers can watch Liverpool vs Atletico Madrid on Paramount+.

Liverpool vs Atletico Madrid: Best Bets & Predictions

Liverpool host Atletico Madrid in a Champions League meeting at Anfield, with two sharply contrasting attacking outlets on show.

Where are you following from? Odds & offers below update to match.

🇺🇸 United StatesTrade on Kalshi 🌎 Outside the USOdds via bet365

Liverpool to winTop pickLiverpool's attacking depth, from Szoboszlai's creativity to Gakpo's return in front of a raucous Anfield crowd, gives the hosts the edge in this Champions League meeting.

59%win prob.-143 @ bet365

Both teams to score – YesJulián Alvarez's proven scoring touch against a Liverpool defense missing a couple of first-choice names points to goals at both ends.

62%chance-163 @ bet365

Over 2.5 goalsBetween Liverpool's creative spread through Szoboszlai and Wirtz and Atletico Madrid's reliance on Alvarez up top, the goalscoring pedigree on show points to a game that clears 2.5 goals.

62%chance-163 @ bet365

Liverpool to win 2-1A narrow home win with a goal at each end fits the shape of this fixture, capturing Liverpool's attacking edge and Atletico Madrid's habit of finding a way through via Alvarez.

12%chance750 @ bet365

Julián Alvarez to score anytimeAlvarez scored 10 goals from 46 shots last season and remains Atletico Madrid's clearest route to goal, making him the value pick to find the net at Anfield.

⭐⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we've built these picks off each side's underlying attacking output – shots, chances created and last season's goal returns for the key men involved – rather than reputation alone, so the result, goals markets and scorer picks all point the same way.

Trade these markets on KalshiNew users get $10 — trade $10 to unlock. Prices update live.

Trade on Kalshi →

If Kalshi isn’t your choice, we also rate Polymarket and ProphetX — or compare the full lineup.

Compare All →

Probabilities reflect live Kalshi market prices at time of loading. 21+. Prediction markets are CFTC-regulated event contracts, not sportsbook bets. Polymarket excluded in AZ, IL, MA, MD, MI, MT, NJ, NV, OH. Please play responsibly. Gambling Problem? Call 1-800-GAMBLER. New Kalshi users: USE CODE SQUAWKA.

Back these with bet365Odds shown for your region — toggle the odds beside each pick above.

Bet with bet365 → bet365 review

Odds correct at time of writing and shown in American format for illustration; your local odds and offer are served on click. Eligibility, minimum age (18+/21+) and T&Cs vary by region. Please gamble responsibly.

Shop the matchLiverpool v Atletico MadridOfficial kits via Fanatics

adidasMen's adidas Red Liverpool 2026/27 Home Replica Jersey$100.00ShopNikeMen's Nike Black Atletico de Madrid 2026/27 Away Stadium Replica Jersey$99.99ShopadidasMen's adidas White Liverpool 2026/27 Away Replica Jersey$100.00Shop

Squawka may earn a commission when you buy through these links, at no extra cost to you. Prices are set by the retailer and correct at time of publishing.

Season Form & Standings

Neither side has a Champions League table position to lean on yet this early in the league phase, with both Liverpool and Atletico Madrid still to open their account in the competition standings, leaving the individual numbers below as the clearest guide to what each side brings to Anfield.

Recent domestic form. Here’s how each side arrives domestically ahead of the European opener:

Potential Match-Winners

• Dominik Szoboszlai (Liverpool): Szoboszlai’s numbers speak for themselves – 5 goals and 29 chances created in 1,053 minutes last season – and he remains Liverpool’s most complete attacking presence.
• Florian Wirtz (Liverpool): Wirtz created more chances than any other Liverpool player last season (32) and added 3 assists, underlining his growing influence as the team’s chief creator.
• Julián Alvarez (Atletico Madrid): Alvarez was Atletico Madrid’s talisman last season, scoring 10 goals from 46 shots and creating 33 chances in 1,240 minutes – a genuine focal point for the visitors.

Liverpool vs Atletico Madrid Prediction

Liverpool’s spread of goal contributions, from Szoboszlai’s five goals to Van Dijk’s two goals and three assists from the back, should be enough to edge this one, though Julián Alvarez’s proven finishing (10 goals last season) gives Atletico Madrid every chance of getting on the scoresheet too. Liverpool to win 2-1 at Anfield.