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    Home » News » Leagues Cup » Philadelphia Union vs Santos Laguna: Predictions, Picks, Odds & Lineups

    Philadelphia Union vs Santos Laguna: Predictions, Picks, Odds & Lineups

    Philadelphia Union vs Santos Laguna predicted lineups Leagues Cup

    Predicted lineups: Philadelphia Union are set up in a 4-4-2 and Santos Laguna in a 4-2-3-1, with both probable XIs in full below.

    In the US, the match streams on Apple TV via MLS Season Pass.

    The market prices the Union as a 64% favorite at Subaru Park, reflecting home advantage and the stakes of a third and final group game. With no draws permitted—level after 90 goes straight to a shootout for split points—both sides face pressure to avoid the penalty lottery and settle it in regulation. Kickoff at Subaru Park is set for 7:00 PM ET / 6:00 PM CT / 4:00 PM PT on Thursday, August 13.

    Philadelphia Union vs Santos Laguna: Best Bets & Predictions

    Goals markets offer cleaner value than the result in a format that punishes defensive caution.

    Where are you following from? Odds & offers below update to match.
    Philadelphia Union to WinTop pickHome advantage and must-win urgency give Philadelphia the edge against visiting Liga MX opposition in a knockout-style fixture.
    64%win prob.Opening soon @ bet365
    Both Teams to Score: YesThe no-draws format forces both sides forward, and neither will settle for penalties when three points remain available.
    60%chanceOpening soon @ bet365
    Over 2.5 GoalsA knockout scenario that eliminates defensive conservatism should deliver the open, attacking game the market expects.
    68%chanceOpening soon @ bet365

    Our approach: lean to the goals rather than the result.

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    Probabilities reflect live Kalshi market prices at time of loading. 21+. Prediction markets are CFTC-regulated event contracts, not sportsbook bets. Please play responsibly. Gambling Problem? Call 1-800-GAMBLER. New Kalshi users: USE CODE SQUAWKA.

    Back these with bet365Leagues Cup prices open closer to kick-off — check bet365 for the latest.
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    Odds shown in American format for illustration; your local odds and offer are served on click. Eligibility, minimum age (18+/21+) and T&Cs vary by region. Please gamble responsibly.

    How Leagues Cup Phase One works

    Every club in the Leagues Cup plays three cross-league games, MLS against Liga MX. There are no draws. If the score is level after 90 minutes, the game goes straight to a penalty shootout, and the winner banks two points while the loser takes one. The top four MLS teams and the top four Liga MX teams then advance to the knockout rounds.

    Shop the matchPhiladelphia Union v Santos LagunaOfficial kits via Fanatics
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    Team News Predicted

    Philadelphia Union vs Santos Laguna Predicted Lineups

    Predicted XI — updated for the latest team news.

    Philadelphia Union

    4-4-2
    A. Blake
    K. Wagner
    N. Harriel
    Neil Pierre
    F. Westfield
    I. Vassilev
    J. Lukic
    D. Jean Jacques
    C. Sullivan
    M. Iloski
    B. Damiani

    Santos Laguna

    4-2-3-1
    C. Acevedo
    E. Echeverria
    F. Sanchez
    F. Pardo
    M. Cuevas
    S. Mariscal
    A. Lopez
    R. Sordo
    Fran Villalba
    E. Bullaude
    E. Aguirre
      Squawka · Team News

      Philadelphia Union vs Santos Laguna prediction

      Philadelphia’s home edge and the format’s attacking incentives point toward a goals-heavy encounter that the Union should edge. Prediction: Philadelphia Union to win, 2-1.

      21+ | Gambling Problem? Call 1-800-GAMBLER | Odds approximate at time of writing