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RB Leipzig vs PSV: Predictions, Picks, Odds & Lineups

RB Leipzig vs PSV predicted formations

RB Leipzig host PSV at Red Bull Arena on Tuesday, October 13 (3:00 PM ET / 2:00 PM CT / 12:00 PM PT).

No fresh fitness concerns are reported for either side, so RB Leipzig should be able to call on Christopher Nkunku and Antonio Nusa in support of the attack, with David Raum again expected at left-back given his creative output from deep. PSV will again lean on Ruben van Bommel and Ivan Perišić in behind Ricardo Pepi, with Sergiño Dest also pushing forward from the back four.

This looks a low-event occasion between two sides still finding their footing. RB Leipzig have 0 points from their opener and a goal difference of -3 after that defeat at Como, while PSV have 1 point to show after a 1-1 draw at home to Shakhtar Donetsk. Neither defence has convinced, and our model expects Leipzig to edge a tight affair at home — though the numbers suggest the market is undervaluing what PSV can do on the road.

RB Leipzig vs PSV: Best Bets & Predictions

Lineups, team news and a Signal-model prediction as RB Leipzig host PSV

RB Leipzig to winTop pickRB Leipzig were beaten 4-1 away at Como in their opener, but the model still favours the hosts to respond at home, with PSV held to a 1-1 draw by Shakhtar Donetsk in theirs.
RB Leipzig 2-1 PSVThe 2-1 scoreline reflects a pattern already seen from both sides — RB Leipzig shipped 4 goals in their opener, and PSV have already let in a goal at home.
Both Teams to Score – YesBoth teams have shown they'll concede — RB Leipzig's goal difference sits at -3 after their opener, and PSV let in a goal despite drawing at home.
Over 2.5 GoalsThe early signs point to goals at both ends: RB Leipzig conceded 4 in their defeat, and PSV's draw already finished 1-1.
Andrija Maksimović to score anytimeAndrija Maksimović already has a goal this season, managing 2 shots – both on target – in 70 minutes.
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Our approach: we weigh each side's underlying numbers from their opening group match, not just the result, to find where the match-winner market and our model's read of the game diverge.

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Season Form & Standings

RB Leipzig sit on 0 points after 1 match, having lost 4-1 away to Como and taken on a goal difference of -3. PSV have 1 point from that game, a 1-1 draw at home against Shakhtar Donetsk, with a goal difference of 0.

Champions League

TeamPosGPWDLGFGAGDPts
PSV2010101101
RB Leipzig32100114-30
Team News Predicted

RB Leipzig vs PSV Predicted Lineups

Predicted XI — updated for the latest team news.

RB Leipzig

4-4-2
M. Vandevoordt
D. Raum
C. Lukeba
W. Orban
R. Baku
A. Nusa
N. Seiwald
N. El Aynaoui
A. Maksimovic
C. Nkunku
Marc Guiu

PSV

4-3-3
M. Kovar
F. Kostic
A. Obispo
L. Geertruida
S. Dest
P. Wanner
K. Sano
G. Til
R. van Bommel
R. Pepi
I. Perisic
    Squawka · Team News

    Potential Match-Winners

    • Andrija Maksimović (RB Leipzig): The midfielder scored in Leipzig’s opening fixture, managing 2 shots – both on target – across 70 minutes.
    • David Raum (RB Leipzig): Left-back David Raum was Leipzig’s most progressive outlet, creating 4 chances in the 90 minutes he played against Como.
    • Ruben van Bommel (PSV): Ruben van Bommel offers PSV’s sharpest end product so far, firing 3 shots and creating 2 chances in the 1-1 draw with Shakhtar Donetsk.

    Recent Form

    RB Leipzig: L

    • 2026-09-10: Como 4-1 RB Leipzig (L, away)

    RB Leipzig’s only game so far ended in a 4-1 defeat away to Como.

    PSV: D

    • 2026-09-10: PSV 1-1 Shakhtar Donetsk (D, home)

    PSV’s lone outing was a 1-1 draw at home to Shakhtar Donetsk.

    RB Leipzig vs PSV Prediction

    Our Signal model lands on a 2-1 win for RB Leipzig, with the hosts edging a tight, low-scoring contest against a PSV side that has already taken a point off Shakhtar Donetsk. The value, though, sits with PSV — the market looks to be underrating a side capable of frustrating better opposition, even as the prediction favours the hosts to win 2-1.