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PSV vs Shakhtar Donetsk: Predictions, Picks, Odds & Stats

PSV vs Shakhtar Donetsk predicted formations

PSV host Shakhtar Donetsk on Thursday, September 10 (12:45 PM ET / 11:45 AM CT / 9:45 AM PT).

PSV go into this one without a clutch of first-team men: the injured Adamo Nagalo, Mikkel Bro, Kilian Sildillia, Dennis Man and Alassane Plea are all out, and long-term absentee Jerdy Schouten remains sidelined by a cruciate ligament injury. That shifts the attacking load onto Ricardo Pepi, who scored three last season from eight shots with six on target, Guus Til, who added two goals and created nine chances, and Ivan Perišić, whose eleven shots last term made him PSV’s most persistent threat from wide. Shakhtar’s own line-up news is unconfirmed for this fixture, so their expected approach will only sharpen closer to kick-off.

This is an opening league-phase fixture for both clubs, so there’s no form line to lean on beyond personnel. PSV’s attacking options give them the clearer identity of the two sides here, and with the visitors’ scouting picture thin in the data available, expect PSV to take the game to Shakhtar and look to make home advantage count.

PSV vs Shakhtar Donetsk: Best Bets & Predictions

Pepi, Til and Perišić lead PSV's attack as they open their Champions League league phase against Shakhtar Donetsk

PSV WinTop pickPSV's attacking options in Pepi, Til and Perišić give them a clear edge over a Shakhtar side whose current form isn't yet on record.
BTTS – YesPSV should create enough chances through Pepi, Til and Perišić to score more than once, and that tends to open the door at the other end too.
Over 2.5 GoalsWith Pepi, Til and Perišić all offering a route to goal for PSV, this looks like the kind of home fixture that tends to produce goals at both ends.
⭐⭐⭐⭐⭐chanceopening soon @ bet365
PSV 2-1 Shakhtar DonetskA 2-1 scoreline fits a home win where PSV's attack does its job but Shakhtar still get on the scoresheet.
Ricardo Pepi Anytime GoalscorerPepi scored three last season from eight shots with six on target, the sharpest conversion rate of PSV's front line.
⭐⭐⭐⭐chanceopening soon @ bet365

Our approach: we lean on PSV's clear standing as favourites and their leading attacking numbers from last season, backing goals from the home side while finding value in a correct score that still lets Shakhtar find the net.

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Season Form & Standings

PSV and Shakhtar Donetsk both sit on zero points from zero games as their Champions League league-phase campaigns get under way, so there’s no table position yet separating the two sides.

Recent domestic form. Here’s PSV’s domestic form ahead of the European opener:

PSV · Eredivisie 2026/27

DWWWW

  • 05 Sep – Ajax 1–3 PSV (A) W
  • 30 Aug – Utrecht 1–6 PSV (A) W
  • 23 Aug – PSV 5–1 Groningen (H) W
  • 15 Aug – Excelsior 1–2 PSV (A) W
  • 08 Aug – PSV 2–2 Fortuna Sittard (H) D

Potential Match-Winners

  • Ricardo Pepi (PSV): Pepi scored three goals last season from eight shots, six of them on target, sharp enough in front of goal to fancy again here.
  • Guus Til (PSV): Til weighed in with two goals and a team-high nine chances created last season, PSV’s clearest creative outlet.
  • Ivan Perišić (PSV): Perišić fired eleven shots last season, more than any other PSV player on this list, and still found the net himself.

PSV vs Shakhtar Donetsk Prediction

With PSV and Shakhtar Donetsk both starting this Champions League league phase on zero points from zero games, the formbook offers little beyond PSV’s home advantage and the attacking numbers behind Pepi, Til and Perišić. We’re backing the hosts to edge it 2-1, with goals at both ends.