Our Chargers vs Bills prediction is the most one-sided read of the early window. Squawka Signal’s live read updates on this page through the week.
The Buffalo Bills lead the league on points scored with 77 in two games and beat Detroit 41-31. The Los Angeles Chargers have managed 28 points across two defeats, both by the same 26-14 scoreline.
Los Angeles Chargers @ Buffalo Bills
Los Angeles ChargersWin prob19%
Buffalo BillsWin prob81%Squawka Signal is our model’s read, updated after every result — not betting advice. How the NFL Signal works. 19+ (18+ in AB/MB/QC). Please play responsibly. ConnexOntario: 1-866-531-2600 (ON). Full T&Cs & geo-restrictions apply: bet365.
Chargers vs Bills: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.
Chargers vs Bills: 2026 form so far
An unbeaten side against a winless one, and the numbers underneath say the same thing. Each attack is set against what the opposite defence has allowed.
Chargers attack against the Bills defence
| Per game | Chargers offence | Bills allow |
|---|---|---|
| Passing yards | 185.0 | 273.0 |
| Rushing yards | 104.0 | 95.0 |
| Yards per carry | 3.9 | 3.7 |
| Passer rating | 71.6 | 118.4 |
| Touchdowns | 2.0 | 4.0 |
| Third-down conversion | 31.8% | 40.7% |
| Red-zone conversion | 80.0% | 77.8% |
| Sacks conceded / recorded | 3.0 | 3.5 |
Bills attack against the Chargers defence
| Per game | Bills offence | Chargers allow |
|---|---|---|
| Passing yards | 283.0 | 262.5 |
| Rushing yards | 144.5 | 86.5 |
| Yards per carry | 5.1 | 2.7 |
| Passer rating | 125.8 | 107.5 |
| Touchdowns | 5.0 | 2.5 |
| Third-down conversion | 57.1% | 35.7% |
| Red-zone conversion | 75.0% | 50.0% |
| Sacks conceded / recorded | 2.0 | 1.5 |
Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.
Buffalo have ten touchdowns in two games. They have also conceded eight, so this is not a defensive team so much as an unstoppable one.
Chargers vs Bills injury report and team news
Josh Allen threw three touchdowns and ran in two more against Detroit at a 121.4 rating.
James Cook III carried 21 times for 135 yards, and Buffalo converted all five red-zone trips.
This section updates as soon as the Out, Doubtful and Questionable tags land.
Los Angeles ChargersBuffalo BillsThe matchup that settles it: Herbert’s turnovers against a team that does not need help
Three Chargers turnovers against Las Vegas is the sort of afternoon Buffalo punish without effort, and Herbert has thrown three interceptions in two games.
Buffalo’s own defence is beatable, conceding a 118.4 rating, but the Chargers have not found anyone to exploit it.
Omarion Hampton is the one Chargers player in form, with 94 yards and a touchdown from 23 carries in Week 2.
Players to watch
- Justin Herbert (LAC, QB): 192 yards, a touchdown and two interceptions against Las Vegas.
- Omarion Hampton (LAC, RB): 23 carries for 94 yards and a score in Week 2.
- Josh Allen (BUF, QB): Three passing touchdowns and two rushing against Detroit.
- James Cook III (BUF, RB): 135 rushing yards at 6.4 a carry in Week 2.
How to watch Chargers vs Bills
The game kicks off at 1:00 PM ET on Sunday, September 27, which is 12:00 PM CT and 10:00 AM PT. CTV has the regional broadcast and RDS the French-language call, and DAZN carries every game of the season. Squawka may earn a commission if you subscribe through that link.
| Detail | Chargers vs Bills |
|---|---|
| Date | Sunday, September 27, 2026 |
| Kickoff | 1:00 PM ET / 12:00 PM CT / 10:00 AM PT |
| Venue | Highmark Stadium, Orchard Park, NY |
| TV | CTV (regional) / RDS (French) |
| Live stream | DAZN (NFL Game Pass) / CTV.ca |
| Week | Week 2, 2026 NFL season |
Chargers vs Bills prediction and score projection
Our Chargers vs Bills prediction is a Buffalo win, 31-20. The Bills score at a rate the Chargers have shown no sign of matching.
Signal’s live number updates on this page through the week.
Every Week 3 game, previewed
| Kickoff (ET) | Game | Our prediction | Preview |
|---|---|---|---|
| Thu 8:15 PM | Falcons @ Packers | Packers 23-10 | Read |
| Sun 1:00 PM | Panthers @ Browns | Panthers 24-20 | Read |
| Sun 1:00 PM | Bengals @ Steelers | Bengals 20-13 | Read |
| Sun 1:00 PM | Texans @ Colts | Colts 26-20 | Read |
| Sun 1:00 PM | Chiefs @ Dolphins | Chiefs 31-17 | Read |
| Sun 1:00 PM | Chargers @ Bills | Bills 31-20 | You are here |
| Sun 1:00 PM | Patriots @ Jaguars | Patriots 20-16 | Read |
| Sun 1:00 PM | Jets @ Lions | Lions 27-20 | Read |
| Sun 1:00 PM | Seahawks @ Commanders | Seahawks 27-17 | Read |
| Sun 1:00 PM | Titans @ Giants | Titans 20-17 | Read |
| Sun 4:05 PM | Cardinals @ 49ers | 49ers 30-13 | Read |
| Sun 4:05 PM | Vikings @ Buccaneers | Vikings 20-17 | Read |
| Sun 4:25 PM | Ravens @ Cowboys | Ravens 30-24 | Read |
| Sun 4:25 PM | Raiders @ Saints | Raiders 24-20 | Read |
| Sun 8:20 PM | Rams @ Broncos | Rams 26-17 | Read |
| Mon 8:15 PM | Eagles @ Bears | Eagles 24-20 | Read |
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 3 game the same way. Compare the AFC Championship odds and NFC Championship odds as the season develops, and our guide to watching the NFL in Canada covers every window.
Chargers vs Bills FAQ
Buffalo, at home. The Bills have scored more points than any team in the league; the Chargers are winless.
1:00 PM ET on Sunday, September 27, which is 12:00 PM CT and 10:00 AM PT.
CTV has the regional broadcast and RDS the French. DAZN streams it too.
The Chargers lost 26-14 to Las Vegas. Buffalo beat Detroit 41-31.
19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change