Our Dolphins vs 49ers prediction is the most one-sided read on the Sunday afternoon card. Squawka Signal’s live read updates on this page through the week.
The Miami Dolphins managed 259 yards at Las Vegas and gave up five sacks. The San Francisco 49ers held the Rams to seven points and scored 27. Week 2 asks Miami to fix the harder of those two problems.
Dolphins vs 49ers: our editor’s props
Two editorial calls to sit alongside the live Signal numbers on this page.
AT 
Our props
An editorial call, not a Signal model output. 19+ (18+ in AB, MB and QC). Please play responsibly.
Dolphins vs 49ers: 2026 form so far
One side arrives having controlled its opener. The other arrives with a line to repair.
| 2026 season to date | Dolphins | 49ers |
|---|---|---|
| Record | 0-1 | 1-0 |
| Points for | 13 | 27 |
| Points against | 27 | 7 |
| Point differential | -14 | +20 |
| Total yards | 259 | 379 |
| Yards per play | 5.2 | 5.9 |
| Turnovers | 2 | 1 |
| Third-down offence | 20.0% | 58.3% |
| Red-zone offence | 33.3% | 66.7% |
| Sacks recorded | 0 | 0 |
| Opponent passer rating | 88.2 | 62.8 |
San Francisco averaged 5.9 yards a play and gave the ball away once. Miami averaged 5.2 and turned it over twice.
Dolphins vs 49ers injury report and team news
Christian McCaffrey carried ten times for 68 yards against the Rams. Brock Purdy finished at a 105.6 rating.
This section updates as soon as the Out, Doubtful and Questionable tags land.
The matchup that settles it: Purdy against a secondary Kirk Cousins beat three times
Miami conceded three touchdown passes at Las Vegas. Purdy threw three of his own against the Rams, which makes the arithmetic uncomfortable.
Malik Willis was sacked five times and threw no touchdowns. San Francisco did not need a single sack to win by 20.
The Dolphins’ two interceptions at Las Vegas are the one encouraging note. They will need more than two to stay in this.
Players to watch
- Malik Willis (MIA, QB): 220 yards, no touchdowns and five sacks taken at Las Vegas.
- De’Von Achane (MIA, RB): 11 carries for 36 yards in the opener.
- Brock Purdy (SF, QB): Three touchdown passes at a 105.6 rating against the Rams.
- Christian McCaffrey (SF, RB): Ten carries for 68 yards at 6.8 a carry.
How to watch Dolphins vs 49ers
The game kicks off at 4:25 PM ET on Sunday, September 20, which is 3:25 PM CT and 1:25 PM PT. CTV has the regional broadcast and RDS the French-language call, and DAZN carries every game of the season. Squawka may earn a commission if you subscribe through that link.
| Detail | Dolphins vs 49ers |
|---|---|
| Date | Sunday, September 20, 2026 |
| Kickoff | 4:25 PM ET / 3:25 PM CT / 1:25 PM PT |
| Venue | Levi’s Stadium, Santa Clara, CA |
| TV | CTV (regional) / RDS (French) |
| Live stream | DAZN (NFL Game Pass) / CTV.ca |
| Week | Week 2, 2026 NFL season |
Dolphins vs 49ers prediction and score projection
Our Dolphins vs 49ers prediction is a San Francisco win, 27-13. The 49ers control games without straining and Miami cannot protect the quarterback.
Signal’s live number updates on this page through the week.
Every fixture in the round is covered across our NFL hub, and Signal rates every Week 2 game the same way. Compare the AFC Championship odds and NFC Championship odds as the season develops, and our guide to watching the NFL in Canada covers every window.
Dolphins vs 49ers FAQ
San Francisco, comfortably. The 49ers conceded seven points in Week 1; Miami scored 13.
4:25 PM ET on Sunday, September 20, which is 3:25 PM CT and 1:25 PM PT.
CTV has the regional broadcast and RDS the French. DAZN carries it as a stream.
Miami lost 27-13 at Las Vegas. San Francisco beat the Rams 27-7.
19+ (18+ in AB, MB and QC) | Please play responsibly | ConnexOntario: 1-866-531-2600 (ON) | Signal probabilities approximate at time of writing and subject to change