{"id":65590,"date":"2026-10-07T03:54:00","date_gmt":"2026-10-07T07:54:00","guid":{"rendered":"https:\/\/www.squawka.com\/us\/?post_type=nfl-news&#038;p=65590"},"modified":"2026-10-07T04:45:05","modified_gmt":"2026-10-07T08:45:05","slug":"49ers-vs-seahawks-prediction-picks-odds-week-5","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/49ers-vs-seahawks-prediction-picks-odds-week-5\/","title":{"rendered":"49ers vs Seahawks Prediction, Picks &#038; Odds"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>San Francisco have not allowed a sack all season. They are the only team in the NFL who can say that, and our <strong>49ers vs Seahawks prediction<\/strong> sends them to the loudest stadium in the league to defend it.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is the game of the week. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> are 4-0 with a +58 point differential, the best in football. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/seattle-seahawks\/\">Seattle Seahawks<\/a> are 3-1 and have conceded 579 passing yards, fewer than anyone else. Something has to give at Lumen Field.<\/p>\n\n\n\n<!-- SQ_NFL_SIGNAL -->\n\n\n\n<style>\n\/* Squawka NFL picks card - palette matched to the injected sq-nsig Signal units *\/\n.sqp{--cy:#2FE6C9;--val:#38D97A;--ovr:#FF6A5A;--fair:#FFC24B;--tx:#e8f0f7;--mut:rgba(232,240,247,.60);--line:rgba(255,255,255,.10);--gold:#FFC24B;position:relative;overflow:hidden;font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;color:var(--tx);max-width:960px;margin:14px auto 26px;border-radius:14px;background:linear-gradient(135deg,#0a2540 0%,#06182b 62%,#04121f 100%);box-shadow:0 14px 36px rgba(4,18,31,.34)}\n.sqp *{box-sizing:border-box}\n.sqp__wrap{padding:22px 26px 20px}\n.sqp__kick{display:inline-flex;align-items:center;gap:8px;font-size:11px;font-weight:800;letter-spacing:.14em;text-transform:uppercase;color:var(--cy)}\n.sqp__kick::before{content:'';width:7px;height:7px;border-radius:50%;background:var(--cy);box-shadow:0 0 9px 1px var(--cy)}\n.sqp__ttl{font-size:24px;font-weight:800;letter-spacing:-.3px;line-height:1.14;margin:12px 0 0;color:var(--tx)}\n.sqp__sub{margin:7px 0 0;font-size:14.5px;line-height:1.5;color:var(--mut);max-width:70ch}\n.sqp__crests{display:flex;align-items:center;gap:10px;margin-top:14px}\n.sqp__crests img{width:28px;height:28px;display:block}\n.sqp__at{font-size:12px;font-weight:700;color:var(--mut);letter-spacing:.1em}\n.sqp__h3{margin:20px 0 0;font-size:10.5px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;color:var(--cy)}\n.sqp__list{margin-top:12px;border-top:1px solid var(--line)}\n.sqp__row{display:grid;grid-template-columns:1fr 126px;gap:14px;align-items:center;padding:14px 2px;border-bottom:1px solid var(--line)}\n.sqp__mkt{display:block;font-size:10px;font-weight:800;letter-spacing:.13em;text-transform:uppercase;color:var(--cy);margin-bottom:4px}\n.sqp__pk{font-size:15.5px;font-weight:800;line-height:1.25;color:var(--tx)}\n.sqp__top{display:inline-block;vertical-align:middle;margin-left:8px;font-size:9.5px;font-weight:800;letter-spacing:.08em;text-transform:uppercase;color:#3a2c00;background:var(--gold);padding:3px 7px;border-radius:5px}\n.sqp__why{display:block;margin-top:5px;font-size:13.5px;line-height:1.5;color:var(--mut)}\n.sqp__pr{text-align:center}\n.sqp__val{display:block;font-size:23px;font-weight:800;color:var(--cy);line-height:1;text-decoration:none}\na.sqp__val:hover{text-decoration:underline}\n.sqp__stars{display:block;font-size:15px;line-height:1;letter-spacing:1px;color:var(--gold)}\n.sqp__stars .o{opacity:.55}\n.sqp__lab{display:block;font-size:10px;letter-spacing:.06em;text-transform:uppercase;color:var(--mut);margin-top:4px}\n.sqp__verd{display:inline-block;margin-top:6px;font-size:10.5px;font-weight:800;letter-spacing:.04em;padding:2px 7px;border-radius:5px}\n.sqp__verd--val{color:var(--val);background:rgba(56,217,122,.12)}\n.sqp__verd--ovr{color:var(--ovr);background:rgba(255,106,90,.12)}\n.sqp__verd--fair{color:var(--fair);background:rgba(255,194,75,.12)}\n.sqp__approach{margin:14px 0 0;font-size:13.5px;line-height:1.55;color:var(--tx)}\n.sqp__foot{margin:16px 0 0;padding-top:13px;border-top:1px solid var(--line);font-size:11.5px;line-height:1.55;color:rgba(232,240,247,.5)}\n.sqp__foot a{color:var(--cy);font-weight:700;text-decoration:none;border-bottom:1px solid rgba(47,230,201,.35)}\n@media(max-width:640px){\n.sqp__wrap{padding:18px 15px 16px}\n.sqp__ttl{font-size:20px}\n.sqp__row{grid-template-columns:1fr 100px;gap:10px}\n.sqp__val{font-size:20px}\n}\n<\/style>\n<div class=\"sqp\" id=\"sqp-sfsea\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 5 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">49ers vs Seahawks: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\" data-props=\"2\">Two editor&#8217;s calls on this game, alongside the live Signal numbers.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SEA.png\" alt=\"Seahawks\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Total\" data-selection=\"Under 45.5 points\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Total<\/span><span class=\"sqp__pk\">Under 45.5 points<\/span><span class=\"sqp__why\">Seattle concede a 72.1 opponent passer rating and 28.6% on third down, both among the three best marks in the league. San Francisco have the best offense in football, which is why this is a lean rather than a conviction.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Jaxon Smith-Njigba 75+ receiving yards\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Jaxon Smith-Njigba 75+ receiving yards<\/span><span class=\"sqp__why\">Smith-Njigba has 481 receiving yards from 32 catches, third in the NFL. San Francisco concede an 87.1 opponent rating, which is respectable rather than suffocating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Seahawks: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The best record in football against the best pass defense. The table measures each attack against what the opposing side has actually conceded.<\/p>\n\n\n\n<h3>49ers attack against the Seahawks defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>49ers offense<\/th><th>Seahawks allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>251.8<\/td><td>144.8<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>137.2<\/td><td>102.0<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>4.8<\/td><td>3.6<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>126.2<\/td><td>72.1<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>4.0<\/td><td>2.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>57.5%<\/td><td>28.6%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>84.6%<\/td><td>66.7%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>0.0<\/td><td>2.8<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>Seahawks attack against the 49ers defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Seahawks offense<\/th><th>49ers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>237.0<\/td><td>209.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>110.2<\/td><td>99.8<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.9<\/td><td>3.7<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>112.1<\/td><td>87.1<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>3.2<\/td><td>1.5<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>31.1%<\/td><td>44.1%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>56.2%<\/td><td>45.5%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>1.5<\/td><td>1.5<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Figures are season to date, across 4 games.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zero sacks allowed in four games and 113 pass attempts. No other team in the league is on fewer than five, and Seattle&#8217;s eleven sacks make this the matchup the game turns on.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Seahawks quarterback matchup<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco&#8217;s 126.2 team passer rating is the highest in the league, and Seattle&#8217;s 112.1 is third. This is the best quarterback matchup on the card.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table><thead><tr><th>Team<\/th><th>Quarterback<\/th><th>Last game<\/th><th>Season to date<\/th><\/tr><\/thead><tbody><tr><td>49ers<\/td><td>Brock Purdy<\/td><td>15\/27, 297 yds, 4 TD, 0 INT, 133.8 rtg<\/td><td>79\/113, 1007 yds, 11 TD, 1 INT, 126.2 rtg (4 games)<\/td><\/tr><tr><td>Seahawks<\/td><td>Sam Darnold<\/td><td>31\/45, 379 yds, 4 TD, 2 INT, 105.7 rtg<\/td><td>45\/69, 560 yds, 6 TD, 3 INT, 101.1 rtg (3 games)<\/td><\/tr><\/tbody><\/table><figcaption>Last game is Week 3. Season figures are 2026 to date, with games played in brackets.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Seahawks injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco&#8217;s receiving room has been thinned by injury, with Ricky Pearsall and Christian Kirk both on injured reserve. Mike Evans and Brandin Cooks have taken on the load alongside George Kittle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Zach Charbonnet is on injured reserve for Seattle, leaving the backfield to Emanuel Wilson and George Holani.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seattle have conceded 579 passing yards, the fewest of any team in the NFL.<\/p>\n\n\n\n<!-- SQ_NFL_INJURIES -->\n\n\n\n<h2 class=\"wp-block-heading\">Zero sacks against eleven<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Start with the protection. San Francisco have given up nothing in 113 attempts, which is why Brock Purdy has eleven touchdown passes and a 126.2 rating, both at or near the top of the league. Clean pockets have produced the best offense in football.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Seattle are the first side equipped to break it. Eleven sacks, a 72.1 opponent passer rating that only Minnesota better, and 28.6% allowed on third down. Lumen Field has historically been worth a false start or two as well.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The 49ers have one genuine vulnerability and it is personnel. With Pearsall and Kirk on injured reserve, the receiving group leans on Mike Evans, Brandin Cooks and Kittle. Against a secondary this good, that is a narrower set of answers than San Francisco have needed so far.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>George Kittle (SF, TE):<\/strong> 244 receiving yards, and the most reliable target in a thinned receiving group.<\/li>\n<li><strong>Christian McCaffrey (SF, RB):<\/strong> 218 rushing yards behind a line that has conceded no sacks.<\/li>\n<li><strong>Jaxon Smith-Njigba (SEA, WR):<\/strong> 481 receiving yards from 32 catches, third in the NFL.<\/li>\n<li><strong>Cooper Kupp (SEA, WR):<\/strong> A second target in a passing game rating 112.1.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch 49ers vs Seahawks<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 4:25 PM ET on Sunday, October 11 at Lumen Field, which is 3:25 PM CT and 1:25 PM PT. FOX has the national broadcast.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>49ers vs Seahawks<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, October 11, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:25 PM ET \/ 3:25 PM CT \/ 1:25 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Lumen Field, Seattle, WA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>FOX<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL+ \/ Fubo<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 5, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Seahawks prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Seattle win 24-21. This is the upset call of the week: the Seahawks have the pass defense to make San Francisco uncomfortable for the first time, and Lumen Field does the rest.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The model&#8217;s number and the live market price for this game both update through the week.<\/p>\n\n\n\n<h2>Every Week 5 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (ET)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Thu 8:15 PM<\/td><td>Buccaneers @ Cowboys<\/td><td>Cowboys 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/buccaneers-vs-cowboys-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 9:30 AM<\/td><td>Eagles @ Jaguars<\/td><td>Jaguars 24-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/eagles-vs-jaguars-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Bears @ Packers<\/td><td>Bears 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/bears-vs-packers-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Bengals @ Dolphins<\/td><td>Bengals 27-16<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/bengals-vs-dolphins-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Browns @ Jets<\/td><td>Browns 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/browns-vs-jets-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Texans @ Titans<\/td><td>Texans 19-16<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/texans-vs-titans-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Colts @ Steelers<\/td><td>Steelers 21-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/colts-vs-steelers-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Raiders @ Patriots<\/td><td>Raiders 23-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/raiders-vs-patriots-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Vikings @ Saints<\/td><td>Vikings 26-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/vikings-vs-saints-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Giants @ Commanders<\/td><td>Giants 24-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/giants-vs-commanders-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Broncos @ Chargers<\/td><td>Broncos 23-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/broncos-vs-chargers-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Lions @ Cardinals<\/td><td>Lions 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/lions-vs-cardinals-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td><strong>49ers @ Seahawks<\/strong><\/td><td>Seahawks 24-21<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 8:20 PM<\/td><td>Ravens @ Falcons<\/td><td>Ravens 26-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/ravens-vs-falcons-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 8:15 PM<\/td><td>Bills @ Rams<\/td><td>Bills 27-23<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/bills-vs-rams-prediction-picks-odds-week-5\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"\/us\/nfl\/picks\/\">NFL predictions for the round<\/a> and <a href=\"\/us\/nfl\/\">our NFL betting coverage<\/a> carry the rest of the card. The outright markets are priced in <a href=\"\/us\/outright-markets\/nfc-championship-odds\/\">the NFC board<\/a>. We price the player markets in <a href=\"\/us\/nfl\/props\/\">prop markets for this game<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">49ers vs Seahawks FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-sfsea-1\"><strong class=\"schema-faq-question\">Who is favored, the 49ers or the Seahawks?<\/strong> <p class=\"schema-faq-answer\">San Francisco on form, at 4-0 with the best point differential in the NFL. Seattle are 3-1 and at home.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfsea-2\"><strong class=\"schema-faq-question\">What time is 49ers vs Seahawks?<\/strong> <p class=\"schema-faq-answer\">4:25 PM ET on Sunday, October 11, at Lumen Field.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfsea-3\"><strong class=\"schema-faq-question\">Have San Francisco really not conceded a sack?<\/strong> <p class=\"schema-faq-answer\">No sacks in four games and 113 pass attempts. They are the only team in the NFL yet to allow one.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-sfsea-4\"><strong class=\"schema-faq-question\">How good is Seattle&#8217;s pass defense?<\/strong> <p class=\"schema-faq-answer\">They have conceded 579 passing yards, the fewest in the league, at a 72.1 opponent rating.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>San Francisco have not allowed a sack all season. They are the only team in the NFL who can say that, and our 49ers vs Seahawks prediction sends them to the loudest stadium in the league to defend it. This is the game of the week. The San Francisco 49ers are 4-0 with a +58&#8230;<\/p>\n","protected":false},"author":394,"featured_media":65589,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"49ers vs seahawks prediction","_yoast_wpseo_title":"49ers vs Seahawks Prediction, Picks & Odds | Squawka","_yoast_wpseo_metadesc":"49ers vs Seahawks prediction, picks and odds for Lumen Field, where the only team yet to concede a sack meets a defense with eleven of them.","footnotes":""},"tags":[350,353,352],"class_list":["post-65590","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-nfl","tag-san-francisco-49ers","tag-seattle-seahawks"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>49ers vs Seahawks Prediction, Picks &amp; Odds | Squawka<\/title>\n<meta name=\"description\" content=\"49ers vs Seahawks prediction, picks and odds for Lumen Field, where the only team yet to concede a sack meets a defense with eleven of them.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/49ers-vs-seahawks-prediction-picks-odds-week-5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"49ers vs Seahawks Prediction, Picks &amp; 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