{"id":55543,"date":"2026-09-22T13:02:33","date_gmt":"2026-09-22T17:02:33","guid":{"rendered":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/"},"modified":"2026-09-22T13:02:34","modified_gmt":"2026-09-22T17:02:34","slug":"cardinals-vs-49ers-prediction-picks-odds-week-3","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/","title":{"rendered":"Cardinals vs 49ers Prediction, Picks &#038; Odds"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Cardinals vs 49ers prediction<\/strong> follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/san-francisco-49ers\/\">San Francisco 49ers<\/a> have conceded no sacks in two games, converted 63.2% of their third downs and scored on 87.5% of their red-zone trips. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/arizona-cardinals\/\">Arizona Cardinals<\/a> managed 151 total yards at home against Seattle. This is a difficult week to visit Levi&#8217;s Stadium.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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.sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model vs market<\/span><h3 class=\"sq-nsig__title\">Arizona Cardinals @ San Francisco 49ers<\/h3><p class=\"sq-nsig__meta\">Week 3 &middot; Sun Sep 27, 4:05 PM ET. Our Signal model makes the <b>San Francisco 49ers<\/b> favorites by about <b>9<\/b> points, a 79% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Arizona Cardinals<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">21%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">22%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--fair\">&#9644; Fair<\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">San Francisco 49ers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">79%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">78%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--fair\">&#9644; Fair<\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">San Francisco 49ers -9<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/kalshi?q=us-all-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Kalshi<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/polymarket?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Polymarket<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/prophet-x?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">ProphetX<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read against devigged market prices, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 21+. Play responsibly. Full T&amp;Cs &amp; geo-restrictions apply: <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/kalshi\/\">Kalshi<\/a>, <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/polymarket\/\">Polymarket<\/a>, <a href=\"https:\/\/www.squawka.com\/us\/bet\/betting-sites\/prophetx\/\">ProphetX<\/a>.<\/p><\/div><\/div>\n\n\n<!-- sqstore:nfl-match -->\n<div style=\"font-family:'Bricolage Grotesque',system-ui,-apple-system,Segoe UI,Roboto,sans-serif;border:1px solid #e4e7ec;border-radius:14px;overflow:hidden;margin:28px 0;background:#fff;\"><div style=\"position:relative;overflow:hidden;background:#0b1e3b;color:#fff;padding:14px 18px;\"><div 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class=\"sqp\" id=\"sqp-arisf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 3 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Cardinals vs 49ers: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"Cardinals\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"49ers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Brock Purdy 2+ passing touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Brock Purdy 2+ passing touchdowns<\/span><span class=\"sqp__why\">Purdy threw two at a 149.1 rating against Miami and San Francisco have five touchdown passes in two games. Arizona have conceded four and a 110.9 rating.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"o\">&#9734;<\/span><\/span><span class=\"sqp__lab\">4\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Team total\" data-selection=\"Arizona under 18.5 points\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Team total<\/span><span class=\"sqp__pk\">Arizona under 18.5 points<\/span><span class=\"sqp__why\">The Cardinals gained 151 yards against Seattle and have three touchdowns all season. San Francisco have conceded two, and only 20% of opponent red-zone trips have scored.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One side is converting nearly everything and the other is converting almost nothing. The table sets each attack against what the other defense has allowed.<\/p>\n\n\n\n<h3>Cardinals attack against the 49ers defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Cardinals offense<\/th><th>49ers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>179.0<\/td><td>175.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>93.0<\/td><td>112.0<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.6<\/td><td>3.9<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>86.2<\/td><td>80.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>1.5<\/td><td>1.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>34.6%<\/td><td>37.5%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>50.0%<\/td><td>20.0%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>1.5<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>49ers attack against the Cardinals defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>49ers offense<\/th><th>Cardinals allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>246.0<\/td><td>203.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>134.5<\/td><td>121.5<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>4.7<\/td><td>4.0<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>125.6<\/td><td>110.9<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>4.0<\/td><td>3.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>63.2%<\/td><td>38.1%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>87.5%<\/td><td>62.5%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>0.0<\/td><td>2.0<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco have not conceded a sack all season and are scoring on seven of eight red-zone trips. Arizona have taken 14 penalties for 159 yards, which does not help an offense already short of yards.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Brock Purdy completed 20 of 22 for 287 yards and two touchdowns against Miami at a 149.1 rating, and San Francisco scored on all five red-zone trips.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jacoby Brissett completed 17 of 28 for 95 yards against Seattle as Arizona held the ball for 23:27.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__inj{flex:0 0 auto;color:rgba(232,240,247,.5);font-size:11px}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__st--lt{background:rgba(160,180,200,.14);color:rgba(232,240,247,.82);border:1px solid rgba(232,240,247,.18)}\n.sq-ninj__lt{margin-top:11px;padding-top:9px;border-top:1px solid rgba(255,255,255,.12)}\n.sq-ninj__lt-h{font-size:10px;font-weight:800;letter-spacing:.06em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:3px}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 3<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/ARI.png\" alt=\"ARI\" loading=\"lazy\" width=\"24\" height=\"24\">Arizona Cardinals<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kaleb Proctor<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Zach Carter<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Chase Bisontis<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">James Conner<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Trey Benson<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Joey Blount<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Kitan Crawford<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jameson Geers<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Tip Reiman<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/SF.png\" alt=\"SF\" loading=\"lazy\" width=\"24\" height=\"24\">San Francisco 49ers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nate Hobbs<\/span><span class=\"sq-ninj__pos\">CB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Alfred Collins<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Andrew Farmer II<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mikail Kamara<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Sam Okuayinonu<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Martin<\/span><span class=\"sq-ninj__pos\">LB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Austen Pleasants<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Brett Toth<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Nick Zakelj<\/span><span class=\"sq-ninj__pos\">OL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Darrick Forrest<\/span><span class=\"sq-ninj__pos\">SAF<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Jake Tonges<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Christian Kirk<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">De&#8217;Zhaun Stribling<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Ricky Pearsall<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Mykel Williams<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Isaac Guerendo<\/span><span class=\"sq-ninj__pos\">RB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">Where Cardinals vs 49ers is decided<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">San Francisco&#8217;s protection is the number that stands out. No sacks conceded in two games, which is why Purdy has completed 45 of 56 and thrown five touchdowns.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Arizona&#8217;s problem is everything in front of the quarterback. One hundred and fifty-one yards against Seattle, 3.2 a play, and 23 and a half minutes of possession.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Consequently Trey McBride is the one route back. He caught eight for 41 and a touchdown in Week 2, and San Francisco have conceded only one touchdown pass.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Trey McBride (ARI, TE):<\/strong> Eight catches and a touchdown against Seattle.<\/li>\n<li><strong>Jacoby Brissett (ARI, QB):<\/strong> 95 passing yards in Week 2, from 28 attempts.<\/li>\n<li><strong>Brock Purdy (SF, QB):<\/strong> 287 yards and two touchdowns at a 149.1 rating against Miami.<\/li>\n<li><strong>George Kittle (SF, TE):<\/strong> Four catches for 80 yards and a score in Week 2.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Cardinals vs 49ers<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 4:05 PM ET on Sunday, September 27 at Levi&#8217;s Stadium, which is 3:05 PM CT and 1:05 PM PT. FOX has the regional broadcast.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Cardinals vs 49ers<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 27, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>4:05 PM ET \/ 3:05 PM CT \/ 1:05 PM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Levi&#8217;s Stadium, Santa Clara, CA<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>FOX<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL+ \/ Fox One<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 3, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Cardinals vs 49ers prediction<\/strong> is a San Francisco win, 30-13. The 49ers are efficient in every phase and Arizona could not move the ball at home last week.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The live win probability and the model&#8217;s projected margin update on this page through the week.<\/p>\n\n\n\n<h2>Every Week 3 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (ET)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Thu 8:15 PM<\/td><td>Falcons @ Packers<\/td><td>Packers 23-10<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/falcons-vs-packers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Panthers @ Browns<\/td><td>Panthers 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/panthers-vs-browns-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Bengals @ Steelers<\/td><td>Bengals 20-13<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/bengals-vs-steelers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Texans @ Colts<\/td><td>Colts 26-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/texans-vs-colts-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Chiefs @ Dolphins<\/td><td>Chiefs 31-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chiefs-vs-dolphins-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Chargers @ Bills<\/td><td>Bills 31-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Patriots @ Jaguars<\/td><td>Patriots 20-16<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/patriots-vs-jaguars-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Jets @ Lions<\/td><td>Lions 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/jets-vs-lions-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Seahawks @ Commanders<\/td><td>Seahawks 27-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/seahawks-vs-commanders-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Titans @ Giants<\/td><td>Titans 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/titans-vs-giants-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td><strong>Cardinals @ 49ers<\/strong><\/td><td>49ers 30-13<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Vikings @ Buccaneers<\/td><td>Vikings 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/vikings-vs-buccaneers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Ravens @ Cowboys<\/td><td>Ravens 30-24<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/ravens-vs-cowboys-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Raiders @ Saints<\/td><td>Raiders 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/raiders-vs-saints-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 8:20 PM<\/td><td>Rams @ Broncos<\/td><td>Rams 26-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/rams-vs-broncos-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 8:15 PM<\/td><td>Eagles @ Bears<\/td><td>Eagles 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/eagles-vs-bears-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/us\/nfl\/\">NFL hub<\/a>, and Signal rates every game on the <a href=\"\/us\/nfl\/picks\/\">NFL picks page<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cardinals vs 49ers FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-arisf-1\"><strong class=\"schema-faq-question\">Who is favored to win, the Cardinals or the 49ers?<\/strong> <p class=\"schema-faq-answer\">San Francisco, at home and heavily. The 49ers are 2-0 with eight touchdowns; Arizona are 1-1 and gained 151 yards last week.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-2\"><strong class=\"schema-faq-question\">What time is Cardinals vs 49ers?<\/strong> <p class=\"schema-faq-answer\">4:05 PM ET on Sunday, September 27, at Levi&#8217;s Stadium.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-3\"><strong class=\"schema-faq-question\">Have San Francisco really not conceded a sack?<\/strong> <p class=\"schema-faq-answer\">None in two games, against the Rams and Miami, which is a large part of why Brock Purdy is completing 80% of his throws.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-arisf-4\"><strong class=\"schema-faq-question\">How did each side do in Week 2?<\/strong> <p class=\"schema-faq-answer\">Arizona lost 31-7 at home to Seattle. San Francisco beat Miami 35-13.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Cardinals vs 49ers prediction follows a San Francisco side that has not let anyone near its quarterback. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week. The San Francisco 49ers have conceded no sacks in two games, converted 63.2% of their third downs and&#8230;<\/p>\n","protected":false},"author":394,"featured_media":55542,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"cardinals vs 49ers prediction","_yoast_wpseo_title":"Cardinals vs 49ers Prediction, Picks & Odds | Squawka","_yoast_wpseo_metadesc":"Our Cardinals vs 49ers prediction, picks and odds for Week 3 at Levi's Stadium. San Francisco have not conceded a sack this season.","footnotes":""},"tags":[375,350,353],"class_list":["post-55543","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-arizona-cardinals","tag-nfl","tag-san-francisco-49ers"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cardinals vs 49ers Prediction, Picks &amp; Odds | Squawka<\/title>\n<meta name=\"description\" content=\"Our Cardinals vs 49ers prediction, picks and odds for Week 3 at Levi&#039;s Stadium. 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