{"id":55528,"date":"2026-09-22T13:02:55","date_gmt":"2026-09-22T17:02:55","guid":{"rendered":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/"},"modified":"2026-09-22T13:02:56","modified_gmt":"2026-09-22T17:02:56","slug":"chargers-vs-bills-prediction-picks-odds-week-3","status":"publish","type":"nfl-news","link":"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/","title":{"rendered":"Chargers vs Bills Prediction, Picks &#038; Odds: Week 3"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Our <strong>Chargers vs Bills prediction<\/strong> sends a stalling offense to the highest-scoring team in the league. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/los-angeles-chargers\/\">Los Angeles Chargers<\/a> have lost both games 26-14, to Arizona and then Las Vegas. The <a href=\"https:\/\/www.squawka.com\/us\/nfl\/teams\/buffalo-bills\/\">Buffalo Bills<\/a> have scored ten touchdowns in two games and converted every red-zone trip against Detroit. One of those patterns is far easier to keep up than the other.<\/p>\n\n\n\n<!-- SQ_NFL_SIG_START -->\n\n<style>\n.sq-nsig{position:relative;overflow:hidden;border-radius:18px;margin:28px 0;isolation:isolate;background:radial-gradient(70% 90% at 18% 0%,rgba(47,230,201,.14) 0%,rgba(47,230,201,0) 60%),linear-gradient(135deg,#0a2540 0%,#06182b 60%,#040f1d 100%);box-shadow:0 18px 44px rgba(4,15,29,.5);font-family:'Bricolage 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.sq-nsig__geo-b,.sq-nsig__geo-r--b:checked~.sq-nsig__cta-row .sq-nsig__geo-b{display:contents}\n<\/style>\n<div class=\"sq-nsig\"><div class=\"sq-nsig__inner\"><span class=\"sq-nsig__tag\"><span class=\"dot\"><\/span>Squawka Signal &middot; Model vs market<\/span><h3 class=\"sq-nsig__title\">Los Angeles Chargers @ Buffalo Bills<\/h3><p class=\"sq-nsig__meta\">Week 3 &middot; Sun Sep 27, 1:00 PM ET. Our Signal model makes the <b>Buffalo Bills<\/b> favorites by about <b>9<\/b> points, a 81% win probability.<\/p><div class=\"sq-nsig__cards\"><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"LAC\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Los Angeles Chargers<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">19%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">26%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--lay\">&#9660; Slight lay<\/span><\/span><\/div><\/div><div class=\"sq-nsig__card\"><div class=\"sq-nsig__sum\"><img decoding=\"async\" class=\"sq-nsig__crest\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"30\" height=\"30\"><span class=\"sq-nsig__name\">Buffalo Bills<\/span><span class=\"sq-nsig__cmp\"><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Squawka<\/span><span class=\"sq-nsig__cmp-sig\">81%<\/span><\/span><span class=\"sq-nsig__cmp-c\"><span class=\"sq-nsig__cmp-k\">Market<\/span><span class=\"sq-nsig__cmp-mkt\">74%<\/span><\/span><span class=\"sq-nsig__verd sq-nsig__verd--val\">&#9650; Value<\/span><\/span><\/div><\/div><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Projected line<\/span><span class=\"sq-nsig__mc-v\">Buffalo Bills -9<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Against the spread<\/span><span class=\"sq-nsig__mc-v\">Buffalo Bills -7 &mdash; model Buffalo Bills -9 vs market Buffalo Bills -7<\/span><\/div><div class=\"sq-nsig__mc\"><span class=\"sq-nsig__mc-k\">Value<\/span><span class=\"sq-nsig__mc-v\">Buffalo Bills &mdash; model 81% vs market 74%<\/span><\/div><div class=\"sq-nsig__cta-row\" style=\"margin-top:14px\"><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/kalshi?q=us-all-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Kalshi<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/polymarket?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">Polymarket<\/a><a class=\"sq-nsig__cta2\" href=\"https:\/\/www.squawka.com\/en\/go\/prophet-x?q=us-sg1-all-wof-s-spo\" rel=\"sponsored nofollow\" target=\"_blank\">ProphetX<\/a><\/div><p class=\"sq-nsig__foot\">Squawka Signal is our model&#8217;s read against devigged market prices, updated after every result &mdash; not betting advice. <a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/nfl-signal-methodology\/\">How the NFL Signal works<\/a>. 21+. 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class=\"sqp\" id=\"sqp-lacbuf\">\n<div class=\"sqp__wrap\">\n<span class=\"sqp__kick\">Week 3 &middot; Editorial pick<\/span>\n<h2 class=\"sqp__ttl\">Chargers vs Bills: our editor&#8217;s props<\/h2>\n<p class=\"sqp__sub\">Two editorial calls to sit alongside the live Signal numbers on this page.<\/p>\n<div class=\"sqp__crests\">\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"Chargers\" loading=\"lazy\" width=\"28\" height=\"28\">\n<span class=\"sqp__at\">AT<\/span>\n<img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"Bills\" loading=\"lazy\" width=\"28\" height=\"28\">\n<\/div>\n<h3 class=\"sqp__h3\">Our props<\/h3>\n<div class=\"sqp__list\">\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"Josh Allen 2+ total touchdowns\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">Josh Allen 2+ total touchdowns<\/span><span class=\"sqp__why\">Allen threw three and ran for two against Detroit at a 121.4 rating. The Chargers have conceded a 107.5 rating and four touchdown passes in two games.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 4 of 5\">&#9733;&#9733;&#9733;&#9733;<span class=\"o\">&#9734;<\/span><\/span><span class=\"sqp__lab\">4\/5 confidence<\/span><\/div>\n<\/div>\n<div class=\"sqp__row\" data-market=\"Player prop\" data-selection=\"James Cook III 70+ rushing yards\" data-read=\"\">\n<div><span class=\"sqp__mkt\">Player prop<\/span><span class=\"sqp__pk\">James Cook III 70+ rushing yards<\/span><span class=\"sqp__why\">Cook carried 21 times for 135 and a score in Week 2. The Chargers have actually held up against the run, conceding 2.7 a carry, so this is the less certain half.<\/span><\/div>\n<div class=\"sqp__pr\"><span class=\"sqp__stars\" role=\"img\" aria-label=\"Confidence 3 of 5\">&#9733;&#9733;&#9733;<span class=\"o\">&#9734;&#9734;<\/span><\/span><span class=\"sqp__lab\">3\/5 confidence<\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"sqp__foot\">An editorial call, not a Signal model output. 21+. Gambling Problem? Call 1-800-GAMBLER.<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Chargers vs Bills: 2026 form so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Two-and-oh against oh-and-two, and the underlying numbers do not offer the Chargers much comfort either. The table sets each attack against what the other defense has allowed.<\/p>\n\n\n\n<h3>Chargers attack against the Bills defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Chargers offense<\/th><th>Bills allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>185.0<\/td><td>273.0<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>104.0<\/td><td>95.0<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>3.9<\/td><td>3.7<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>71.6<\/td><td>118.4<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>2.0<\/td><td>4.0<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>31.8%<\/td><td>40.7%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>80.0%<\/td><td>77.8%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>3.0<\/td><td>3.5<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<h3>Bills attack against the Chargers defense<\/h3>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Per game<\/th><th>Bills offense<\/th><th>Chargers allow<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Passing yards<\/td><td>283.0<\/td><td>262.5<\/td><\/tr>\n<tr><td>Rushing yards<\/td><td>144.5<\/td><td>86.5<\/td><\/tr>\n<tr><td>Yards per carry<\/td><td>5.1<\/td><td>2.7<\/td><\/tr>\n<tr><td>Passer rating<\/td><td>125.8<\/td><td>107.5<\/td><\/tr>\n<tr><td>Touchdowns<\/td><td>5.0<\/td><td>2.5<\/td><\/tr>\n<tr><td>Third-down conversion<\/td><td>57.1%<\/td><td>35.7%<\/td><\/tr>\n<tr><td>Red-zone conversion<\/td><td>75.0%<\/td><td>50.0%<\/td><\/tr>\n<tr><td>Sacks conceded \/ recorded<\/td><td>2.0<\/td><td>1.5<\/td><\/tr>\n<\/tbody><\/table><\/figure>\n<p><em>Read these as a 2-game sample rather than settled form. Rates this early move a long way on one result.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Buffalo are scoring on 75% of their red-zone trips and converting 57.1% on third down. The Chargers are at 31.8% on third down with three interceptions thrown.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Chargers vs Bills injury report and team news<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Justin Herbert completed 15 of 27 for 192 yards with a touchdown and two interceptions against Las Vegas, and the Chargers gave the ball away three times.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Omarion Hampton carried 23 times for 94 yards and a touchdown, comfortably the busiest back on either side.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This section updates as soon as the Out, Doubtful and Questionable tags land.<\/p>\n\n\n\n<!-- SQ_NFL_INJ_START -->\n\n<style>\n.sq-ninj{border:1px solid #123f5c;border-radius:14px;overflow:hidden;margin:24px 0;font-family:'Bricolage Grotesque',system-ui,-apple-system,sans-serif;background:#0a2540;color:#e8f0f7}\n.sq-ninj__head{display:flex;align-items:baseline;justify-content:space-between;gap:10px;padding:13px 16px;background:#06182b;font-weight:800;font-size:13px;letter-spacing:.4px;text-transform:uppercase;color:#fff;border-bottom:1px solid #123f5c}\n.sq-ninj__head span{font-size:11px;font-weight:600;letter-spacing:0;text-transform:none;color:rgba(232,240,247,.6)}\n.sq-ninj__cols{display:flex;flex-wrap:wrap}\n.sq-ninj__col{flex:1 1 260px;padding:14px 16px}\n.sq-ninj__col+.sq-ninj__col{border-left:1px solid #123f5c}\n.sq-ninj__team{display:flex;align-items:center;gap:9px;font-weight:800;font-size:14px;color:#fff;margin-bottom:10px}\n.sq-ninj__team img{width:24px;height:24px;object-fit:contain}\n.sq-ninj__row{display:flex;align-items:center;gap:8px;padding:6px 0;border-top:1px solid rgba(255,255,255,.06);font-size:13.5px}\n.sq-ninj__nm{flex:1;min-width:0;color:#fff;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}\n.sq-ninj__pos{flex:0 0 auto;color:rgba(232,240,247,.55);font-size:11px;font-weight:700}\n.sq-ninj__inj{flex:0 0 auto;color:rgba(232,240,247,.5);font-size:11px}\n.sq-ninj__st{flex:0 0 auto;font-size:10.5px;font-weight:800;letter-spacing:.04em;text-transform:uppercase;padding:3px 9px;border-radius:999px}\n.sq-ninj__st--out{background:rgba(255,106,90,.16);color:#FF6A5A}\n.sq-ninj__st--doubt{background:rgba(255,194,75,.16);color:#FFC24B}\n.sq-ninj__st--ques{background:rgba(232,240,247,.1);color:rgba(232,240,247,.8)}\n.sq-ninj__st--lt{background:rgba(160,180,200,.14);color:rgba(232,240,247,.82);border:1px solid rgba(232,240,247,.18)}\n.sq-ninj__lt{margin-top:11px;padding-top:9px;border-top:1px solid rgba(255,255,255,.12)}\n.sq-ninj__lt-h{font-size:10px;font-weight:800;letter-spacing:.06em;text-transform:uppercase;color:rgba(232,240,247,.5);margin-bottom:3px}\n.sq-ninj__none{font-size:13px;color:rgba(232,240,247,.55);padding:4px 0}\n@media(max-width:520px){.sq-ninj__col+.sq-ninj__col{border-left:0;border-top:1px solid #123f5c}}\n<\/style><div class=\"sq-ninj\"><div class=\"sq-ninj__head\">Injury report &middot; Week 3<span>Official game-status report &mdash; updates through the week<\/span><\/div><div class=\"sq-ninj__cols\"><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/LAC.png\" alt=\"LAC\" loading=\"lazy\" width=\"24\" height=\"24\">Los Angeles Chargers<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Tyler Biadasz<\/span><span class=\"sq-ninj__pos\">C<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Scott Matlock<\/span><span class=\"sq-ninj__pos\">FB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Branson Taylor<\/span><span class=\"sq-ninj__pos\">G<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Denzel Perryman<\/span><span class=\"sq-ninj__pos\">LB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Charlie Kolar<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">David Njoku<\/span><span class=\"sq-ninj__pos\">TE<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">KeAndre Lambert-Smith<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><\/div><\/div><div class=\"sq-ninj__col\"><div class=\"sq-ninj__team\"><img decoding=\"async\" src=\"https:\/\/www.squawka.com\/us\/wp-content\/themes\/squawka\/inc\/NFL\/assets\/team-logos\/BUF.png\" alt=\"BUF\" loading=\"lazy\" width=\"24\" height=\"24\">Buffalo Bills<\/div><div class=\"sq-ninj__none\">No game-status designations filed yet.<\/div><div class=\"sq-ninj__lt\"><div class=\"sq-ninj__lt-h\">Out long-term<\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Dorian Strong<\/span><span class=\"sq-ninj__pos\">CB<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Zane Durant<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">IR<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Tyrell Shavers<\/span><span class=\"sq-ninj__pos\">WR<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">PUP<\/span><\/div><div class=\"sq-ninj__row\"><span class=\"sq-ninj__nm\">Phidarian Mathis<\/span><span class=\"sq-ninj__pos\">DL<\/span><span class=\"sq-ninj__st sq-ninj__st--lt\">Susp<\/span><\/div><\/div><\/div><\/div><\/div>\n\n<!-- SQ_NFL_INJ_END -->\n\n\n\n<h2 class=\"wp-block-heading\">Where Chargers vs Bills is decided<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Buffalo went five from five in the red zone against Detroit and converted nine of twelve third downs. That is a team in complete control of its own possessions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Chargers have not been outclassed so much as stalled. Thirty-one per cent on third down across two games, three interceptions, and an identical 26-14 defeat each time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nevertheless Buffalo are not stopping anybody either. They have conceded a 118.4 passer rating and eight touchdowns, and Detroit put 31 on them while losing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Players to watch<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Justin Herbert (LAC, QB):<\/strong> 192 yards, a touchdown and two interceptions against Las Vegas.<\/li>\n<li><strong>Omarion Hampton (LAC, RB):<\/strong> 23 carries for 94 yards and a score in Week 2.<\/li>\n<li><strong>Josh Allen (BUF, QB):<\/strong> Three passing touchdowns and two rushing against Detroit.<\/li>\n<li><strong>James Cook III (BUF, RB):<\/strong> 135 rushing yards at 6.4 a carry in Week 2.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to watch Chargers vs Bills<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Kickoff is 1:00 PM ET on Sunday, September 27 at Highmark Stadium, which is 12:00 PM CT and 10:00 AM PT. FOX has the regional broadcast.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\">\n<thead>\n<tr><th>Detail<\/th><th>Chargers vs Bills<\/th><\/tr>\n<\/thead>\n<tbody>\n<tr><td><strong>Date<\/strong><\/td><td>Sunday, September 27, 2026<\/td><\/tr>\n<tr><td><strong>Kickoff<\/strong><\/td><td>1:00 PM ET \/ 12:00 PM CT \/ 10:00 AM PT<\/td><\/tr>\n<tr><td><strong>Venue<\/strong><\/td><td>Highmark Stadium, Orchard Park, NY<\/td><\/tr>\n<tr><td><strong>TV<\/strong><\/td><td>FOX<\/td><\/tr>\n<tr><td><strong>Live stream<\/strong><\/td><td>NFL+ \/ Fox One<\/td><\/tr>\n<tr><td><strong>Week<\/strong><\/td><td>Week 3, 2026 NFL season<\/td><\/tr>\n<\/tbody>\n<\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Chargers vs Bills prediction and score projection<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Our <strong>Chargers vs Bills prediction<\/strong> is a Buffalo win, 31-20. The Bills score too freely for a side averaging 14 points a game to keep up, even with Buffalo leaking yards.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The live win probability and the model&#8217;s projected margin update on this page through the week.<\/p>\n\n\n\n<h2>Every Week 3 game, previewed<\/h2>\n<figure class=\"wp-block-table is-style-stripes\"><table>\n<thead><tr><th>Kickoff (ET)<\/th><th>Game<\/th><th>Our prediction<\/th><th>Preview<\/th><\/tr><\/thead>\n<tbody>\n<tr><td>Thu 8:15 PM<\/td><td>Falcons @ Packers<\/td><td>Packers 23-10<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/falcons-vs-packers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Panthers @ Browns<\/td><td>Panthers 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/panthers-vs-browns-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Bengals @ Steelers<\/td><td>Bengals 20-13<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/bengals-vs-steelers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Texans @ Colts<\/td><td>Colts 26-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/texans-vs-colts-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Chiefs @ Dolphins<\/td><td>Chiefs 31-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chiefs-vs-dolphins-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td><strong>Chargers @ Bills<\/strong><\/td><td>Bills 31-20<\/td><td><em>You are here<\/em><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Patriots @ Jaguars<\/td><td>Patriots 20-16<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/patriots-vs-jaguars-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Jets @ Lions<\/td><td>Lions 27-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/jets-vs-lions-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Seahawks @ Commanders<\/td><td>Seahawks 27-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/seahawks-vs-commanders-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 1:00 PM<\/td><td>Titans @ Giants<\/td><td>Titans 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/titans-vs-giants-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Cardinals @ 49ers<\/td><td>49ers 30-13<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/cardinals-vs-49ers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:05 PM<\/td><td>Vikings @ Buccaneers<\/td><td>Vikings 20-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/vikings-vs-buccaneers-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Ravens @ Cowboys<\/td><td>Ravens 30-24<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/ravens-vs-cowboys-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 4:25 PM<\/td><td>Raiders @ Saints<\/td><td>Raiders 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/raiders-vs-saints-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Sun 8:20 PM<\/td><td>Rams @ Broncos<\/td><td>Rams 26-17<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/rams-vs-broncos-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<tr><td>Mon 8:15 PM<\/td><td>Eagles @ Bears<\/td><td>Eagles 24-20<\/td><td><a href=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/eagles-vs-bears-prediction-picks-odds-week-3\/\">Read<\/a><\/td><\/tr>\n<\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Every fixture in the round is covered across our <a href=\"\/us\/nfl\/\">NFL hub<\/a>, and Signal rates every game on the <a href=\"\/us\/nfl\/picks\/\">NFL picks page<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Chargers vs Bills FAQ<\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-lacbuf-1\"><strong class=\"schema-faq-question\">Who is favored to win, the Chargers or the Bills?<\/strong> <p class=\"schema-faq-answer\">Buffalo, at home and comfortably. The Bills are 2-0 with ten touchdowns; the Chargers are 0-2 and have scored 28 points in total.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-lacbuf-2\"><strong class=\"schema-faq-question\">What time is Chargers vs Bills?<\/strong> <p class=\"schema-faq-answer\">1:00 PM ET on Sunday, September 27, at Highmark Stadium.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-lacbuf-3\"><strong class=\"schema-faq-question\">Have the Chargers really lost both games by the same score?<\/strong> <p class=\"schema-faq-answer\">Yes. Arizona beat them 26-14 in Week 1 and Las Vegas by the same scoreline in Week 2.<\/p><\/div><div class=\"schema-faq-section\" id=\"faq-lacbuf-4\"><strong class=\"schema-faq-question\">How did each side do in Week 2?<\/strong> <p class=\"schema-faq-answer\">The Chargers lost 26-14 to Las Vegas. Buffalo beat Detroit 41-31.<\/p><\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>21+ | Gambling Problem? Call 1-800-GAMBLER | Signal probabilities and odds approximate at time of writing and subject to change<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Chargers vs Bills prediction sends a stalling offense to the highest-scoring team in the league. Squawka Signal&#8217;s live read on this game, including where the value sits, updates on this page through the week. The Los Angeles Chargers have lost both games 26-14, to Arizona and then Las Vegas. The Buffalo Bills have scored&#8230;<\/p>\n","protected":false},"author":394,"featured_media":55527,"menu_order":0,"template":"","meta":{"_acf_changed":false,"_yoast_wpseo_focuskw":"chargers vs bills prediction","_yoast_wpseo_title":"Chargers vs Bills Prediction, Picks & Odds: Week 3 | Squawka","_yoast_wpseo_metadesc":"Our Chargers vs Bills prediction, picks and odds for Week 3 at Highmark. The Chargers have lost both games by the same 26-14 scoreline.","footnotes":""},"tags":[365,376,350],"class_list":["post-55528","nfl-news","type-nfl-news","status-publish","has-post-thumbnail","hentry","tag-buffalo-bills","tag-los-angeles-chargers","tag-nfl"],"acf":{"external_featured_image_url":"","hide_featured_image_pattern":false},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Chargers vs Bills Prediction, Picks &amp; Odds: Week 3 | Squawka<\/title>\n<meta name=\"description\" content=\"Our Chargers vs Bills prediction, picks and odds for Week 3 at Highmark. 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The Chargers have lost both games by the same 26-14 scoreline.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.squawka.com\/us\/nfl\/nfl-news\/chargers-vs-bills-prediction-picks-odds-week-3\/\" \/>\n<meta property=\"og:site_name\" content=\"Squawka | US\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/SquawkaFootballNews\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-22T17:02:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.squawka.com\/images\/sites\/13\/2026\/09\/22123104\/wk3-us-preview-chargers-bills.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2400\" \/>\n\t<meta property=\"og:image:height\" content=\"1260\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Squawka\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"FAQPage\"],\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/chargers-vs-bills-prediction-picks-odds-week-3\\\/\",\"url\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/chargers-vs-bills-prediction-picks-odds-week-3\\\/\",\"name\":\"Chargers vs Bills Prediction, Picks & Odds: Week 3 | Squawka\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/chargers-vs-bills-prediction-picks-odds-week-3\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.squawka.com\\\/us\\\/nfl\\\/nfl-news\\\/chargers-vs-bills-prediction-picks-odds-week-3\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/media.squawka.com\\\/images\\\/sites\\\/13\\\/2026\\\/09\\\/22123104\\\/wk3-us-preview-chargers-bills.jpg\",\"datePublished\":\"2026-09-22T17:02:55+00:00\",\"dateModified\":\"2026-09-22T17:02:56+00:00\",\"description\":\"Our Chargers vs Bills prediction, picks and odds for Week 3 at Highmark. 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